Sodium alendronate used in bone treatment

Abstract

The thermally induced interactions of sodium alendronate trihydrate in 1:1 mass ratio binary mixture with talc, silica, magnesium stearate, microcrystalline cellulose, starch, gelatin and mannitol were studied under nonisothermal conditions. The heat flow (HF) signal, obtained by converting the temperature differences (DTA) into power units, was used for detecting the thermally induced events. By all the seven excipients, no thermally induced interactions with alendronate were observed, but the thermal stability of the excipients is very different. The talc and silica, as expected, are very thermostable. By starch, gelatin, and microcrystalline cellulose, the HF signal corresponding to the thermo degradation is over 270°C, the deamination step of alendronate. The magnesium stearate and mannitol substances are not recommended for solid formulation due to its low thermal stability.

Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration

“…Bisphosphonates are a group of drugs commonly used to treat various bone diseases, including osteoporosis, malignant hypercalcemia, or Paget's disease. Alendronate (Alen or [(4-amino-1-hydroxybutylidene)-bisphosphonate] trihydrate [26] is an amino bisphosphonate that signifcantly improves bone density and mass in the treatment of periodontal defects [27]. Alen has an afnity for calcium phosphate and binds tightly to hydroxyapatite [28].…”