SOCS1 Prevents Potentially Skin-Reactive Cytotoxic T Lymphocytes from Gaining the Ability to Cause Inflammatory Lesions

Rodriguez, Galaxia M.; D'Urbano, Dante; Bobbala, Diwakar; Chen, Xi Lin; Yeganeh, Mehdi; Ramanathan, Sheela; Ilangumaran, Subburaj

doi:10.1038/jid.2013.86

Cited by 9 publications

(5 citation statements)

References 54 publications

(95 reference statements)

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“…Rodriguez et al demonstrated that suppressor of cytokine signaling1 ( Socs1) −/− MHC-I-restricted premelanosome protein-1 (Pmel-1) transgenic TCR CD8 + T cells expressed higher levels of Blimp-1 upon stimulation with cognate self-antigen (mgp10025–33) than did wild type Pmel-1 cells, suggesting that SOCS1 regulates Blimp-1. However, the underlying mechanism of this effect is unknown [99]. Kurachi et al demonstrated that a basic leucine zipper transcription factor (BATF) is essential for operation of the differentiation checkpoint in early effector CD8 + T cells.…”

Section: Transcriptional Regulation Of Blimp-1 In T Cellsmentioning

confidence: 99%

New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

Yeh

Chu

et al. 2017

J Biomed Sci

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B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified within the past decade, we review recent findings with emphasis on its role in coordinated control of gene expression during the development, differentiation, and function of T cells. Expression of Blimp-1 is mainly confined to activated T cells and is essential for the production of interleukin (IL)-10 by a subset of forkhead box (Fox)p3+ regulatory T cells with an effector phenotype. Blimp-1 is also required to induce cell elimination in the thymus and critically modulates peripheral T cell activation and proliferation. In addition, Blimp-1 promotes T helper (Th) 2 lineage commitment and limits Th1, Th17 and follicular helper T cell differentiation. Furthermore, Blimp-1 coordinates with other transcription factors to regulate expression of IL-2, IL-21 and IL-10 in effector T lymphocytes. In CD8+ T cells, Blimp-1 expression is distinct in heterogeneous populations at the stages of clonal expansion, differentiation, contraction and memory formation when they encounter antigens. Moreover, Blimp-1 plays a fundamental role in coordinating cytokine receptor signaling networks and transcriptional programs to regulate diverse aspects of the formation and function of effector and memory CD8+ T cells and their exhaustion. Blimp-1 also functions as a gatekeeper of T cell activation and suppression to prevent or dampen autoimmune disease, antiviral responses and antitumor immunity. In this review, we discuss the emerging roles of Blimp-1 in the complex regulation of gene networks that regulate the destiny and effector function of T cells and provide a Blimp-1-dominated transcriptional framework for T lymphocyte homeostasis.

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Section: Transcriptional Regulation Of Blimp-1 In T Cellsmentioning

confidence: 99%

New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

Yeh

Chu

et al. 2017

J Biomed Sci

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“…Moreover, pmel-1 mice have been increasingly employed to study autoimmune vitiligo [7], [60]–[64] and uveitis [61], [63], [65]. The pmel-1 mouse was generated using two transgenic vectors, which contained variable domains of the endogenous TCR as described previously [7] (Figure S1).…”

Section: Introductionmentioning

confidence: 99%

Identification of the Genomic Insertion Site of Pmel-1 TCR α and β Transgenes by Next-Generation Sequencing

Abrams

Zhu

et al. 2014

PLoS ONE

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The pmel-1 T cell receptor transgenic mouse has been extensively employed as an ideal model system to study the mechanisms of tumor immunology, CD8+ T cell differentiation, autoimmunity and adoptive immunotherapy. The ‘zygosity’ of the transgene affects the transgene expression levels and may compromise optimal breeding scheme design. However, the integration sites for the pmel-1 mouse have remained uncharacterized. This is also true for many other commonly used transgenic mice created before the modern era of rapid and inexpensive next-generation sequencing. Here, we show that whole genome sequencing can be used to determine the exact pmel-1 genomic integration site, even with relatively ‘shallow’ (8X) coverage. The results were used to develop a validated polymerase chain reaction-based genotyping assay. For the first time, we provide a quick and convenient polymerase chain reaction method to determine the dosage of pmel-1 transgene for this freely and publically available mouse resource. We also demonstrate that next-generation sequencing provides a feasible approach for mapping foreign DNA integration sites, even when information of the original vector sequences is only partially known.

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“…It has been previously shown that differential expression of UCHL1 was majorly involved in the proliferation and differentiation of T cells, including CD8 memory CTLp, circulating TCR-gamma/delta+ lymphocytes, and mature T cells [ 59 ]. SOCS1 has been identified as an inhibitor against cytokine release and a growth factor receptor, it plays a crucial role in regulating T cell homeostasis, development, and homeostasis activation [ 60 – 64 ]. However, the function of OSTM1, PCGF2, PSMD2, and USP54 have not been investigated in the antitumoral immune response.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of ubiquitin-proteasome system genes related to prognosis and immunosuppression in head and neck squamous cell carcinoma

Wang

Zhang

et al. 2021

Aging

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The ubiquitin-proteasome system (UPS) with a capacity of degrading multiple intracellular proteins is an essential regulator in tumor immunosurveillance. Tumor cells that escape from recognition and destruction of immune system have been consistently characterized an important hallmark in the setting of tumor progression. Little know about the exact functions of UPS-related genes (UPSGs) and their relationships with antitumor immunity in head and neck squamous cell carcinoma (HNSCC) patients. In this study, for the first time, we comprehensively identified 114 differentially expressed UPSGs (DEUPSGs) and constructed a prognostic risk model based on the eight DEUPSGs (BRCA1, OSTM1, PCGF2, PSMD2, SOCS1, UCHL1, UHRF1, and USP54) in the TCGA-HNSCC database. This risk model was validated using multiple data sets (all P < 0.05). The high-risk score was found to be an independently prognostic factor in HNSCC patients and was significantly correlated with T cells suppression. Accordingly, our risk model can act as a prognostic signature and provide a novel concept for improving the precise immunotherapy for patients with HNSCC.

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SOCS1 Prevents Potentially Skin-Reactive Cytotoxic T Lymphocytes from Gaining the Ability to Cause Inflammatory Lesions

Cited by 9 publications

References 54 publications

New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

Identification of the Genomic Insertion Site of Pmel-1 TCR α and β Transgenes by Next-Generation Sequencing

Comprehensive analysis of ubiquitin-proteasome system genes related to prognosis and immunosuppression in head and neck squamous cell carcinoma

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