Socket Preservation with d-PTFE Membrane: Histologic Analysis of the Newly Formed Matrix at Membrane Removal

Laurito, Domenico; Cugnetto, Riccardo; Lollobrigida, Marco; Guerra, Fabrizio; Vestri, Annarita; Gianno, Francesca; Bosco, Sandro; Lamazza, Luca; Biase, Alberto De

doi:10.11607/prd.2114

Cited by 25 publications

(36 citation statements)

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“…Many studies have evaluated the success of ARP involving different type of bone grafts and barrier membranes . However, only some studies have reported on the healing of treated extraction sockets at different time points.…”

Section: Discussionmentioning

confidence: 99%

“…The advantages of using a d‐PTFE membrane include the possibility of leaving the membranes intentionally exposed without compromising the healing process, preserving the alveolar bone, and the likelihood of increasing the amount of keratinized mucosa . The efficacy of this barrier membrane with other graft materials has also been demonstrated . ‒ …”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it eliminates the need for obtaining a primary wound closure during the surgery and facilitates membrane removal at the postoperative visit . The efficacy of this barrier membrane has been demonstrated in preclinical and human studies with regard to augmenting an extraction sockets before implant placement . ‒ …”

Section: Introductionmentioning

confidence: 99%

“…25,29 The efficacy of this barrier membrane has been demonstrated in preclinical and human studies with regard to augmenting an extraction sockets before implant placement. 13,21,[30][31][32] The ideal time of implant placement in an augmented ridge however is still a controversial topic for many clinicians and patients who are constantly at pursuit for expedited replacement therapy. 33 Therefore, this study was designed to histologically compare the healing of augmented extraction sockets treated at 2, 4, and 6 months using a combination of mineralized bone allograft-plug socket augmentation 18 with a d-PTFE membrane for differences in the amount of vital bone, residual graft particles, and connective tissue (CT)/other.…”

Section: Introductionmentioning

confidence: 99%

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Time analysis of alveolar ridge preservation using a combination of mineralized bone‐plug and dense‐polytetrafluoroethylene membrane: A histomorphometric study

Wen

Barootchi

Huang

et al. 2019

Journal of Periodontology

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Background The objective of this study was to histologically evaluate and compare vital bone formation, residual graft particles, and fraction of connective tissue (CT)/other tissues between three different time points at 2‐month intervals after alveolar ridge preservation with a cancellous allograft and dense‒polytetrafluoroethylene (d‐PTFE) membrane. Methods Ridge preservation with a cancellous allograft and d‐PTFE membrane was performed at 49 extraction sockets (one per patient). Volunteers were assigned to implant placement at three different time points of 2, 4, and 6 months, at which time core biopsies were obtained. Histomorphometric analysis was performed to determine the percentages of vital bone, residual graft particles, and connective tissue/other non‐bone components, and subjected to statistical analyses. Results There was a statistically significant difference in the amount of vital bone at every time point from 28.31% to 40.87% to 64.11% (at 2‐, 4‐, and 6‐month groups, respectively) (P < 0.05). The percentage of residual graft particles ranged from 44.57% to 36.16% to 14.86%, showing statistical significance from 4 to 6 months (21.29%, P < 0.001), and 2 to 6 months (29.71%, P < 0.001), while there were no significant differences for the amount of CT/other tissue among the different time points. Conclusions This study provided the first histologic comparison of alveolar ridge preservation using a cancellous allograft and d‐PTFE membrane at three different time points. Extraction sockets that healed for 6 months produced the highest amount of vital bone in combination with the least percentage of residual graft particles, while similar results were observed for the fraction of CT/other tissues between the three time points.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Time analysis of alveolar ridge preservation using a combination of mineralized bone‐plug and dense‐polytetrafluoroethylene membrane: A histomorphometric study

Wen

Barootchi

Huang

et al. 2019

Journal of Periodontology

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“…After the removal of the membrane, the underlying tissue appeared reddish in color and friable in texture. One study investigated the histological characteristics of this tissue, revealing that it was composed of a dense connective matrix with a large number of fibroblasts and inflammatory cells, but no epithelial cells . The role of this tissue has yet to be completely elucidated, but it appears to act like provisional matrix for epithelialization by separating the bone substitute material and the oral environment.…”

Section: Discussionmentioning

confidence: 99%

Alveolar ridge preservation using an open membrane approach for sockets with bone deficiency: A randomized controlled clinical trial

Sun

Lim

Lee

2018

Clin Implant Dent Rel Res

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Background Various approaches are used for alveolar ridge preservation (ARP); however, there is no standard method or material. Purpose To investigate the effect of ARP with a dense polytetrafluoroethylene (d‐PTFE) membrane and freeze‐dried irradiated allogenic bone for sockets with bone deficiency. Materials and Methods Thirty‐four patients (with sockets exhibiting ≥3 mm hard tissue loss in ≥1 walls) were randomized to undergo natural socket healing (control) or ARP with a d‐PTFE membrane and freeze‐dried irradiated allogenic bone (test group). After 4 months, horizontal and vertical ridge changes were measured using cone beam computed tomography. Results Ridge width at l mm below the ridge crest demonstrated significantly less change in the test group (median =2.3; Q1 = 0.6; Q3 = 4.3 mm) than in the control group (median =3.9; Q1 =2.6; Q3 = 7.8 mm; P = .021). There was no significant difference between the two groups in horizontal ridge changes at 3 and 5 mm below the crest or vertical changes ( P > .05). Requirement for bone augmentation at implant placement was significantly reduced in the test group compared to the control group ( P < .001). Conclusion ARP with a d‐PTFE membrane and freeze‐dried irradiated allogenic bone substitute reduced horizontal bone resorption in sockets with bone deficiency.

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Evaluation of healing at molar extraction sites with ridge preservation using a non‐resorbable dense polytetrafluoroethylene membrane: A four‐arm cohort prospective study

Hugail

Mealey

Walker

et al. 2021

Clinical & Exp Dental Res

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Objectives: To examine ridge dimensional changes and histologic parameters of healing when ridge preservation (RP) was performed at molar sites using dense polytetrafluoroethylene (dPTFE) membrane alone, without a bone graft.Material and Methods: Eighteen patients had molar extraction and RP using dPTFE membrane alone. Ridge dimensions were measured using two standardized cone beam computerized tomography (CBCT) scans taken within 72 h and 3 months following extraction. Following a 3-month healing period, an implant osteotomy was prepared using a trephine drill and bone cores were collected for histological analysis.Four-arm analyses were performed using data from three previously published study arms of the same research group.Results: There was a significant change in the buccal ridge height between the four groups at all aspects of the socket. Alveolar ridge width reduction at 3 mm from crest for all aspects (mesial, midpoint, distal) of the socket showed statistically significant difference for dPTFE alone group compared to the other three groups. Percentage of vital bone formation (62.10%) was significantly greater in dPTFE alone group compared to the other groups.Conclusions: RP using dPTFE membrane alone in molar sites with intact socket walls showed successful outcomes in maintaining ridge dimensions and in histologic wound healing.

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Socket Preservation with d-PTFE Membrane: Histologic Analysis of the Newly Formed Matrix at Membrane Removal

Cited by 25 publications

References 0 publications

Time analysis of alveolar ridge preservation using a combination of mineralized bone‐plug and dense‐polytetrafluoroethylene membrane: A histomorphometric study

Time analysis of alveolar ridge preservation using a combination of mineralized bone‐plug and dense‐polytetrafluoroethylene membrane: A histomorphometric study

Alveolar ridge preservation using an open membrane approach for sockets with bone deficiency: A randomized controlled clinical trial

Evaluation of healing at molar extraction sites with ridge preservation using a non‐resorbable dense polytetrafluoroethylene membrane: A four‐arm cohort prospective study

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