Socioeconomic Status and Survival in Nasopharyngeal Carcinoma: A <scp>Population‐Based</scp> Study

Brody-Camp, Sabrina; McCoul, Edward D.; Lefante, John J.; Aslam, Rizwan

doi:10.1002/lary.29702

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…The male population tends to use less contact lenses than the female population, which may be the reason [ 26 ]. The explanation of lower infectious keratitis rate in sub-urban habitat is unclear since people living in sub-urban are not necessarily of poor socioeconomic status [ 38 ]. However, the upper limit of 95% CI is close to one, thus the significance may not be clinically important.…”

Section: Discussionmentioning

confidence: 99%

The Nasopharyngeal Carcinoma and Its Effect on the Infectious Eye Disease: A Nationwide Cohort Study

Lee

Hsieh

Huang

et al. 2022

Cancers

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The purpose of this study is to investigate the potential correlation between nasopharyngeal carcinoma (NPC) and both infectious keratitis and orbital cellulitis. The retrospective cohort study used the National Health Insurance Research Database (NHIRD) as a data source. A total number of 4184 patients with NPC diagnosis were selected and matched to 16,736 non-NPC patients via the propensity-score matching (PSM). The main outcomes are the development of infectious keratitis and orbital cellulitis according to diagnostic codes and related medications. The Cox proportional hazard regression was adopted to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of outcomes between the two groups. A total of 35 and 19 episodes of orbital cellulitis occurred in the NPC and non-NPC groups and the aHR was significantly higher in the NPC group (aHR: 1.34, 95% CI: 1.23–1.46, p = 0.0024). There were 2185 and 659 events of infectious keratitis in the NPC and non-NPC groups, and the NPC group revealed a significantly higher aHR than non-NPC group (aHR: 1.34, 95% CI: 1.23–1.46, p < 0.0001). Besides, the cumulative probability of infectious keratitis was significantly higher in the NPC group than the non-NPC group (p < 0.0001). The other risk factors of infectious keratitis include age from 20 to 30 years old, allergic respiratory diseases, allergic dermatological diseases, and external eye diseases (all p < 0.0001). In subgroup analyses, both the incidences of infectious keratitis (aHR: 1.33, 95% CI: 1.21–1.47) and orbital cellulitis (aHR: 2.36, 95% CI: 1.27–4.39) were significantly higher than the non-NPC group. The incidence of infectious keratitis was significantly higher in NPC patients without radiotherapy (aHR: 1.40, 95% CI: 1.26–1.55) compared to non-NPC population, while the rate of orbital cellulitis was similar between the NPC patients without radiotherapy (aHR: 0.76, 95% CI: 0.27–2.14) and non-NPC population. In conclusion, the existence of NPC associates with higher incidence of infectious keratitis which increases with NPC period, and the radiotherapy may be account for the higher rate of orbital cellulitis in NPC population.

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Section: Discussionmentioning

confidence: 99%

The Nasopharyngeal Carcinoma and Its Effect on the Infectious Eye Disease: A Nationwide Cohort Study

Lee

Hsieh

Huang

et al. 2022

Cancers

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“…The most assessed outcome was advanced overall stage at presentation or diagnosis among 37 studies (74%). 1,[11][12][13][14][15]20,21,23,26,27,[29][30][31][32][34][35][36][37][39][40][41][42][43]45,[47][48][49][51][52][53][54][55][56][57][58]63 Other options included advanced tumor size, advanced nodal disease,…”

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

Inequities Associated With Advanced Stage at Presentation of Head and Neck Cancer

Ioerger,

Mills,

Wagoner

et al. 2024

JAMA Otolaryngol Head Neck Surg

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ImportanceSocial determinants of health (SDoH) are defined by a wide range of factors (eg, built environment, economic stability, education level, discrimination, racism, access to health care). Advanced stage at presentation or delayed diagnosis heavily influences health outcomes in patients with head and neck cancer (HNC). While the drivers of advanced-stage presentation come from a multitude of sources, SDoH plays an outsized role.ObjectiveTo systematically review the published literature to identify which SDoH are established as risk factors for delayed diagnosis or advanced stage at presentation among patients with HNC.Evidence ReviewIn this systematic review, a literature search of PubMed, Web of Science, and Embase was conducted on February 27, 2023, using keywords related to advanced stage at presentation and delayed diagnosis of HNC between 2013 and 2023. Quality assessment was evaluated through the Newcastle-Ottawa Scale. Articles were included if they focused on US-based populations and factors associated with advanced stage at presentation or delayed diagnosis of HNC.FindingsOverall, 50 articles were included for full-text extraction, of which 30 (60%) were database studies. Race was the most commonly reported variable (46 studies [92%]), with Black race (43 studies [93%]) being the most studied racial group showing an increased risk of delay in diagnosis of HNC. Other commonly studied variables that were associated with advanced stage at presentation included sex and gender (41 studies [82%]), insurance status (25 studies [50%]), geographic region (5 studies [10%]), and socioeconomic status (20 studies [40%]). Male sex, lack of insurance, rurality, and low socioeconomic status were all identified as risk factors for advanced stage at presentation.Conclusions and RelevanceThis systematic review provides a comprehensive list of factors that were associated with advanced HNC stage at presentation. Future studies should focus on evaluating interventions aimed at addressing the SDoH in communities experiencing disparities to provide a net positive effect on HNC care.

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“…In 2020, approximately 133,000 people were diagnosed with NPC, and there were approximately 80,000 NPC-related deaths (a mortality rate of approximately 60%) (Sung et al, 2021). Due to the lack of effective early diagnostic indicators, most patients are diagnosed at an advanced stage and are prone to distant metastasis (Guinot et al, 2020;Brody-Camp et al, 2021). Therefore, early and accurate diagnosis is of great importance for the prevention and treatment of NPC.…”

Section: Introductionmentioning

confidence: 99%

Application of small extracellular vesicles in the diagnosis and prognosis of nasopharyngeal carcinoma

Zhang

Huang

Lan

et al. 2023

Front. Cell Dev. Biol.

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Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelium of the nasopharynx. The disease is insidious, and most patients are diagnosed at the advanced stage, resulting in poor prognosis. Early diagnosis is important to reduce NPC mortality. Small extracellular vesicles (sEVs) are rich in a variety of bioactive molecules, such as proteins, nucleic acids, and lipids, which can participate in the physiological and pathological regulation of the body by affecting the function of target cells. Numerous studies have shown that some RNAs and proteins in sEVs of tumor origin have a key role in the development of NPC and are potential candidates for malignancy detection. Studying the relationship between the cargoes of these sEVs and NPC may help in the diagnosis of the disease. Here in this review, we summarize the application of sEVs as biomarkers in the diagnosis of NPC and their role in NPC metastasis and prognosis. In addition, we discuss possible future applications and limitations of sEVs as biomarkers.

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Socioeconomic Status and Survival in Nasopharyngeal Carcinoma: A Population‐Based Study

Cited by 7 publications

References 10 publications

The Nasopharyngeal Carcinoma and Its Effect on the Infectious Eye Disease: A Nationwide Cohort Study

The Nasopharyngeal Carcinoma and Its Effect on the Infectious Eye Disease: A Nationwide Cohort Study

Inequities Associated With Advanced Stage at Presentation of Head and Neck Cancer

Application of small extracellular vesicles in the diagnosis and prognosis of nasopharyngeal carcinoma

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