Socioeconomic Status and Childhood Asthma in Urban Minority Youths. The GALA II and SAGE II Studies

Thakur, Neeta; Oh, Sam S.; Nguyen, Elizabeth A.; Martin, Melissa; Roth, Lindsey A.; Galanter, Joshua; Gignoux, Christopher R.; Eng, Celeste; Davis, Adam; Meade, Kelley; LeNoir, Michael A.; Avila, Pedro C.; Farber, Harold J.; Serebrisky, Denise; Brigino-Buenaventura, Emerita; Rodríguez-Cintrón, William; Kumar, Rajesh; Williams, L. Keoki; Bibbins‐Domingo, Kirsten; Thyne, Shannon; Sen, Sáunak; Rodríguez‐Santana, José; Borrell, Luisa N.; Burchard, Esteban G.

doi:10.1164/rccm.201306-1016oc

Cited by 114 publications

(84 citation statements)

References 53 publications

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“…Another US study concluded that higher odds of asthma were associated with a lower SEP for African-American children and a higher SEP for Mexican-American children, while results for the "other Latino" group were not significant [50].…”

Section: Association Between Allergic Diseases and Sepmentioning

confidence: 96%

A systematic review of socioeconomic position in relation to asthma and allergic diseases

et al. 2014

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The role of socioeconomic position (SEP) in the development of asthma and allergies is unclear, with some pointing to the risks of low SEP and other research pointing in the direction of higher SEP being associated with higher prevalence rates. The aim of this systematic review is to clarify associations between SEP and the prevalence of asthma and allergies. Out of 4407 records identified, 183 were included in the analysis. Low SEP was associated with a higher prevalence of asthma in 63% of the studies. Research on allergies, however, showed a positive association between higher SEP and illness in 66% of studies. Pooled estimates for the odds ratio of disease for the highest compared with the lowest SEP confirmed these results for asthma (unadjusted OR 1.38, 95% CI 1.37-1.39), allergies in general (OR 0.67, 95% CI 0.62-0.72), atopic dermatitis (unadjusted OR 0.72, 95% CI 0.61-0.83) and allergic rhinoconjunctivitis (unadjusted OR 0.52, 95% CI 0.46-0.59). Sensitivity analyses with a subsample of highquality studies led to the same conclusion. Evidence from this systematic review suggests that asthma is associated with lower SEP, whereas the prevalence of allergies is associated with higher SEP. @ERSpublications Lower socioeconomic position associated with higher prevalence of asthma and lower prevalence of allergies

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Section: Association Between Allergic Diseases and Sepmentioning

confidence: 96%

A systematic review of socioeconomic position in relation to asthma and allergic diseases

et al. 2014

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“…Minority populations are at higher risk of developing asthma and having more severe asthma relative to the general population (16). Potential reasons include reduced access and responsiveness to medication and other socioeconomic factors (17,18). Regional variation in air pollution composition may also be an important factor leading to heterogeneous health effects (19).…”

mentioning

confidence: 99%

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes–Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies

Neophytou

White²,

Oh³

et al. 2016

Am J Respir Crit Care Med

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Rationale: Adverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking.Objectives: To assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry. Methods:The study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter <10 mm and <2.5 mm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. Measurements and Main Results:A 5 mg/m 3 increase in average lifetime particulate matter less than or equal to 2.5 mm in diameter exposure was associated with a 7.7% decrease in FEV 1 (95% confidence interval = 211.8 to 23.5%) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function.Conclusions: Early-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers.

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“…Thakur and colleagues found that lower socioeconomic status was associated with a higher prevalence of asthma in African Americans, but that lower socioeconomic status was associated with a lower prevalence of asthma in Mexican Americans (30). In Mexican Americans, some of this effect appears to be due to level of acculturation.…”

Section: Obesitymentioning

confidence: 99%

Update in Asthma 2013

Cohn¹,

Woodruff²

2014

Am J Respir Crit Care Med

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Socioeconomic Status and Childhood Asthma in Urban Minority Youths. The GALA II and SAGE II Studies

Abstract: Socioeconomic status plays an important role in predicting asthma, but has different effects depending on race and ethnicity. Further steps are necessary to better understand the risk factors through which socioeconomic status could operate in these populations to prevent asthma.

Cited by 114 publications

References 53 publications

A systematic review of socioeconomic position in relation to asthma and allergic diseases

A systematic review of socioeconomic position in relation to asthma and allergic diseases

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes–Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies

Update in Asthma 2013

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