Socioeconomic Position, But Not African Genomic Ancestry, Is Associated With Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging

Lima‐Costa, Maria Fernanda; Mambrini, Juliana Vaz de Melo; Leite, Maria Léa Corrêa; Peixoto, Sérgio Viana; Firmo, Josélia Oliveira Araújo; Filho, Antônio Ignácio de Loyola; Gouveia, Mateus H.; Leal, Thiago P.; Pereira, Alexandre C.; Macinko, James; Tarazona‐Santos, Eduardo

doi:10.1161/hypertensionaha.115.06609

Cited by 23 publications

(14 citation statements)

References 27 publications

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“…Finally, in another evaluation of GBD 2015, arterial hypertension, the most relevant risk factor for cerebrovascular disease, was identified as the main factor in terms of all-cause mortality and morbidity 27 . In addition, in the cohort of Bambuí, in the state of Minas Gerais, the incidence of hypertension was significantly higher among the poor and those with less formal education, independently of factors related to ethnicity and/or genetic ancestry 28 . Thus, actions directly linked to the detection, treatment, and control of arterial hypertension are shown as the way to reduce the magnitude and regional differences of cerebrovascular disease, as it has already occurred in other countries 29 .…”

Section: Discussionmentioning

confidence: 89%

Doença cerebrovascular no Brasil de 1990 a 2015: Global Burden of Disease 2015

Lotufo

Goulart

Passos

et al. 2017

Rev. bras. epidemiol.

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The risk of death has been halved across the country, but states in the lower SDI tertile had less significant reductions (-1.23 and -1.84% a year) compared to the middle tertile (-1.94 and -2.22%) and the upper tertile (-2.85 and -2.82%) for men and women, respectively. The years lived with disability also presented a reduction among states, but less expressively. Conclusion: Despite the reduction of age-adjusted mortality rates throughout the country, cerebrovascular disease still presents a high disease burden, especially in states with lower socioeconomic development.

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Section: Discussionmentioning

confidence: 89%

Doença cerebrovascular no Brasil de 1990 a 2015: Global Burden of Disease 2015

Lotufo

Goulart

Passos

et al. 2017

Rev. bras. epidemiol.

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“…Although high blood pressure is common in SSA, a study from Brazil [ 29 ] supports a view that it is socioeconomic factors (such as low levels of education and income) and not genetic composition (African, European, or Native American) that are the important predictors. No significant difference between adults in Sierra Leone and the Gambia was found [ 4 ], and a meta-analysis also failed to find a consistent relationship with ethnicity [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Hypertension in a Population of Undergraduate Students in Sierra Leone

Lebbie

Wadsworth

Saidu

et al. 2017

International Journal of Hypertension

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We report on the first survey of hypertension in undergraduates in Sierra Leone. Levels of hypertension (12%) and obesity (4%) appear low compared to the general population but given the rapid increase of both and the expectation that many graduates will enter the formal employment sector and a sedentary lifestyle, there is still cause for concern. We measured their BMI (body mass index) and used a questionnaire to investigate demographic and lifestyle choices. In agreement with most authorities, we found that BMI and age were statistically significant predictors of systolic and diastolic blood pressure but that the explanatory power was low ( = 0.21 to 0.27). Men may be more sensitive than women to an increase in BMI on blood pressure ( < 0.1). We failed to find statistically significant relationships with ethnicity, religion, stress, course of study, levels of physical activity, diet, smoking, or consumption of caffeine and alcohol. Family history of hypertension, consumption of red palm oil, and self-diagnosed attacks of typhoid fever were close to conventional levels of significance ( < 0.1). We intend to use this as a baseline for longitudinal studies to assess risks and suggest appropriate public health action.

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“…Much more compelling is the need for a more global distribution of research groups with a strong background in genomics and bioinformatics, leading and performing this kind of study. In this context, the overarching goal of the EPIGEN-Brazil Initiative is to study the genomic diversity and its effects on complex phenotypes in Brazil, the most populous Latin American country (Borges et al 2016;Lima-Costa et al 2016;Marques et al 2017). Brazil's more than 200 million inhabitants are the product of admixture that occurred during the last 500 years between Amerindians, Europeans, Africans, and their descendants.…”

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confidence: 99%

EPIGEN-Brazil Initiative resources: a Latin American imputation panel and the Scientific Workflow

et al. 2018

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EPIGEN-Brazil is one of the largest Latin American initiatives at the interface of human genomics, public health, and computational biology. Here, we present two resources to address two challenges to the global dissemination of precision medicine and the development of the bioinformatics know-how to support it. To address the underrepresentation of non-European individuals in human genome diversity studies, we present the EPIGEN-5M+1KGP imputation panel-the fusion of the public 1000 Genomes Project (1KGP) Phase 3 imputation panel with haplotypes derived from the EPIGEN-5M data set (a product of the genotyping of 4.3 million SNPs in 265 admixed individuals from the EPIGEN-Brazil Initiative). When we imputed a target SNPs data set (6487 admixed individuals genotyped for 2.2 million SNPs from the EPIGEN-Brazil project) with the EPIGEN-5M+1KGP panel, we gained 140,452 more SNPs in total than when using the 1KGP Phase 3 panel alone and 788,873 additional high confidence SNPs ( ≥ 0.8). Thus, the major effect of the inclusion of the EPIGEN-5M data set in this new imputation panel is not only to gain more SNPs but also to improve the quality of imputation. To address the lack of transparency and reproducibility of bioinformatics protocols, we present a conceptual Scientific Workflow in the form of a website that models the scientific process (by including publications, flowcharts, masterscripts, documents, and bioinformatics protocols), making it accessible and interactive. Its applicability is shown in the context of the development of our EPIGEN-5M+1KGP imputation panel. The Scientific Workflow also serves as a repository of bioinformatics resources.

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Socioeconomic Position, But Not African Genomic Ancestry, Is Associated With Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging

Cited by 23 publications

References 27 publications

Doença cerebrovascular no Brasil de 1990 a 2015: Global Burden of Disease 2015

Doença cerebrovascular no Brasil de 1990 a 2015: Global Burden of Disease 2015

Predictors of Hypertension in a Population of Undergraduate Students in Sierra Leone

EPIGEN-Brazil Initiative resources: a Latin American imputation panel and the Scientific Workflow

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