Socioeconomic disadvantage and episodic memory ability in the ABCD sample: Contributions of hippocampal subregion and subfield volumes

Botdorf, Morgan; Dunstan, Jade; Sorcher, Leah; Dougherty, Lea R.; Riggins, Tracy

doi:10.1016/j.dcn.2022.101138

Cited by 18 publications

(22 citation statements)

References 66 publications

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“…The direction of the effect identified in this study—larger volumes of CA1‐2 and CA3‐DG subfields related to lower SES—differed from the direction hypothesized based on the extant evidence (Botdorf et al, 2022; Merz et al, 2019). Our finding may be interpreted in the context of the stress acceleration hypothesis that posits faster brain maturation, particularly in the hippocampus, in low SES individuals due to greater chronic stress (Baum et al, 1999; Callaghan & Tottenham, 2016; Humphreys et al, 2019; Tooley et al, 2021).…”

Section: Figurecontrasting

confidence: 89%

“…Higher parental education also correlates with lower hair cortisol levels in 5‐to 9‐year‐olds (Merz et al, 2019). Further, larger CA1, DG‐CA4, and Sub hippocampal subfield volumes correlate with higher SES in 9‐ to 13‐year‐olds (Botdorf et al, 2022). Thus, childhood appears to be a period when hippocampal structures are vulnerable to factors associated with household SES, providing a window onto mechanisms of cognitive change associated with early life SES effects on cognitive development.…”

Section: Figurementioning

confidence: 99%

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Household socioeconomic status relates to specific hippocampal subfield volumes across development

Canada

Homayouni

et al. 2023

Hippocampus

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The hippocampus is composed of cytoarchitecturally distinct subfields that support specific memory functions. Variations in total hippocampal volume across development have been linked to socioeconomic status (SES), a proxy for access to material resources, medical care, and quality education. High childhood household SES is associated with greater cognitive abilities in adulthood. Currently, it is not known whether household SES differentially impacts specific hippocampal subfield volumes. We assessed susceptibility of subfields to variations in household SES across development in a sample of 167 typically developing 5‐ to 25‐year‐old. Bilateral cornu ammonis (CA) 1–2, combined CA3‐dentate gyrus (DG), and subiculum (Sub) volumes were measured by highly reliable manual segmentation of high‐resolution T2‐weighted images and adjusted for intracranial volume. A summary component score of SES measures (paternal education, maternal education, and income‐to‐needs ratio) was used to examine variability in volumes across ages. We did not identify age‐related differences in any of the regional volumes, nor did age modify SES‐related effects. Controlling for age, larger volumes of CA3‐DG and CA1‐2 were associated with lower SES, while Sub volume was not. Overall, these findings support the specific impact of SES on CA3‐DG and CA1‐2 and highlight the importance of considering environmental influences on hippocampal subfield development.

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Section: Figurecontrasting

confidence: 89%

Section: Figurementioning

confidence: 99%

Household socioeconomic status relates to specific hippocampal subfield volumes across development

Canada

Homayouni

et al. 2023

Hippocampus

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“…The CA1 subfield is squarely in the anterior (head) portion of the hippocampus, while their dentate gyrus subfield can span the head and body of the hippocampus. Botdorf and coworkers found smaller anterior and posterior volumes in the hippocampus with greater area deprivation index, a census-based index of SES 45 . Decker et al found that lower household income was related to smaller anterior hippocampal volumes 44 .…”

Section: Discussionmentioning

confidence: 98%

“…Related to SES, limited work has examined if there are potential alterations in volumes of amygdala and hippocampal subdivisions. Three past studies have found anterior hippocampal volumes (i.e., Dentate gyrus; CA1) were positively related to different operationalizations of SES, including parental education 43 , family household income 44 , and socioeconomic conditions in a census tract 45 . Notably, no work to date has examined amygdala subdivisions in relation to SES.…”

Section: Introductionmentioning

confidence: 99%

Impact of Socioeconomic Status on Amygdala and Hippocampus Subdivisions in Children and Adolescents

Hanson

Adkins

Nacewicz

et al. 2023

Preprint

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Socioeconomic status (SES) in childhood can impact behavioral and brain development. Past work has consistently focused on the amygdala and hippocampus, two brain areas critical for emotion and behavioral responding. While there are SES differences in amygdala and hippocampal volumes, there are many unanswered questions in this domain connected to neurobiological specificity, and for whom these effects may be more pronounced. We may be able to investigate some anatomical subdivisions of these brain areas, as well as if relations with SES vary by participant age and sex. No work to date has however completed these types of analyses. To overcome these limitations, here, we combined multiple, large neuroimaging datasets of children and adolescents with information about neurobiology and SES (N=2765). We examined subdivisions of the amygdala and hippocampus and found multiple amygdala subdivisions, as well as the head of the hippocampus, were related to SES. Greater volumes in these areas were seen for higher-SES youth participants. Looking at age- and sex-specific subgroups, we tended to see stronger effects in older participants, for both boys and girls. Paralleling effects for the full sample, we see significant positive associations between SES and volumes for the accessory basal amygdala and head of the hippocampus. We more consistently found associations between SES and volumes of the hippocampus and amygdala in boys (compared to girls). We discuss these results in relation to conceptions of 'sex-as-a-biological variable' and broad patterns of neurodevelopment across childhood and adolescence. These results fill in important gaps on the impact of SES on neurobiology critical for emotion, memory, and learning.

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“…Specifically, lower household SES associates with lower total gray matter volume (Dennis et al, 2022; Jednoróg et al, 2012; Luby et al, 2013; Mackey et al, 2015; McDermott et al, 2019), cortical gray matter volume (Luby et al, 2013; Mackey et al, 2015), cortical thickness (Colich et al, 2020; Mackey et al, 2015; McDermott et al, 2019; Noble et al, 2015), and cortical surface area (McDermott et al, 2019) in youth. Regionally, SES is positively associated with hippocampal (Botdorf et al, 2022; Hanson et al, 2011; Jednoróg et al, 2012; Luby et al, 2013; McDermott et al, 2019; Noble et al, 2015, 2012; Ramphal et al, 2021) and amygdala (Assari, 2020; Assari et al, 2020; Luby et al, 2013; McDermott et al, 2019; Ramphal et al, 2021) volumes across childhood and adolescence, although some studies have failed to replicate findings in the amygdala (Hanson et al, 2011; Noble et al, 2012). Lower SES has also been shown to associate with lower global white matter volumes in one study (McDermott et al, 2019) but not in others (Jednoróg et al, 2012; Mackey et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Relative Brain Age Is Associated with Socioeconomic Status and Anxiety/Depression Problems in Youth

Cohen

Ramphal

DeSerisy

et al. 2022

Preprint

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Socioeconomic status (SES) has been linked to differences in brain structure and psychiatric risk across the lifespan. Despite many neuropsychiatric disorders emerging in childhood, few studies have examined the influence of SES on brain aging and psychopathology in youth. We re-analyzed relative brain age (RBA) data from the Healthy Brain Network to examine the influence of SES components (parent education, occupation, household income-to-needs ratio (INR), public assistance enrollment) on RBA. RBA was previously determined using covariation patterns for cortical morphology, white, and subcortical gray matter volumes without SES in predictive models. We also examined associations between RBA and psychiatric symptoms (child behavior checklist). Full case analysis included 470 youth (5-17 years; 61.3% male), self-identifying as White (55%), African American (15%), Hispanic (9%), or multiracial (17.2%). Mean household income was 3.95+/-2.33 (Mean+/-SD) times the federal poverty threshold. Multiple linear regression examined if 1) SES components associated with RBA, and 2) RBA associated with psychiatric symptoms. Models covaried for sex, scan location, and parent psychiatric diagnoses. RBA associated with public assistance (p = 0.03), parent occupation (p = 0.01), and parent psychiatric diagnosis (p = 0.01), but not with INR and parent education. Parent occupation (p = 0.02) and RBA (p = 0.04) associated with CBCL anxiety/depression scores. Components of SES associated with brain aging, underscoring the risk of omitting these factors in developmental brain research. Further, delayed brain aging was associated with low parental occupational prestige and child anxiety/depression scores, suggesting a possible biological pathway from SES to mental health risk.

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Socioeconomic disadvantage and episodic memory ability in the ABCD sample: Contributions of hippocampal subregion and subfield volumes

Cited by 18 publications

References 66 publications

Household socioeconomic status relates to specific hippocampal subfield volumes across development

Household socioeconomic status relates to specific hippocampal subfield volumes across development

Impact of Socioeconomic Status on Amygdala and Hippocampus Subdivisions in Children and Adolescents

Relative Brain Age Is Associated with Socioeconomic Status and Anxiety/Depression Problems in Youth

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