Socioeconomic Determinants of Health and Cardiovascular Outcomes in Women

Lindley, Kathryn J.; Aggarwal, Niti R.; Briller, Joan; Davis, Melinda B.; Douglass, Paul; Epps, Kelly; Fleg, Jerome L.; Hayes, Sharonne N.; Itchhaporia, Dipti; Mahmoud, Zainab; Oliveira, Gláucia Maria Moraes de; Ogunniyi, Modele O.; Quesada, Odayme; Russo, Andrea M.; Sharma, Jyoti; Wood, Malissa J.

doi:10.1016/j.jacc.2021.09.011

Cited by 59 publications

(57 citation statements)

References 79 publications

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“…Overall, lower income, living in rural areas, belonging to a racial minority, lower social support, and lower levels of education have been associated with higher risk of cardiovascular events, all factors that disproportionately affect women. 96 Further studies to evaluate the impact of socioeconomic factors on outcomes of patients with cardiomyopathies are warranted.…”

Section: Socioeconomic Determinants Of Health In Womenmentioning

confidence: 99%

Sex‐Related Differences in Genetic Cardiomyopathies

Argirò

Day

et al. 2022

JAHA

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Cardiomyopathies are a heterogeneous collection of diseases that have in common primary functional and structural abnormalities of the heart muscle, often genetically determined. The most effective categorization of cardiomyopathies is based on the presenting phenotype, with hypertrophic, dilated, arrhythmogenic, and restrictive cardiomyopathy as the prototypes. Sex modulates the prevalence, morpho‐functional manifestations and clinical course of cardiomyopathies. Aspects as diverse as ion channel expression and left ventricular remodeling differ in male and female patients with myocardial disease, although the reasons for this are poorly understood. Moreover, clinical differences may also result from complex societal/environmental discrepancies between sexes that may disadvantage women. This review provides a state‐of‐the‐art appraisal of the influence of sex on cardiomyopathies, highlighting the many gaps in knowledge and open research questions.

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Section: Socioeconomic Determinants Of Health In Womenmentioning

confidence: 99%

Sex‐Related Differences in Genetic Cardiomyopathies

Argirò

Day

et al. 2022

JAHA

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“…African American women also have a higher prevalence of comorbidities such as obesity, diabetes, and chronic kidney disease [ 1 , 3 – 5 ], are less likely to engage in health behaviors that reduce CVD risk [ 6 ], and are less likely to be aware of HTN as a heart disease risk factor [ 7 ]. Furthermore, this group is more likely to experience socioeconomic adversity compared to white women [ 8 – 10 ]; even so, higher socioeconomic status (SES) African American women are less likely to experience health gains from their socioeconomic resources compared to white women of similar or equal SES [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic characteristics of African American women attending community blood pressure screenings

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Isiadinso

Mehta

et al. 2022

American Heart Journal Plus: Cardiology Research and Practice

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“…Cardiovascular diseases always cause HF and may even lead to mortality ( 22 ). The high and increasing mortality and morbidity rates of cardiovascular disease have created a socio-economic burden ( 23 ). Despite great advances in therapeutic approaches and drug treatments in the last decades, effective curative treatments of HF remain limited ( 24 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of LncRNA-HFRL expression induces cardiomyocyte inflammation, proliferation, and fibrosis via the sequestering of miR-149-5p-mediated collagen 22A inhibition

Teng

Tian

et al. 2022

Ann Transl Med

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Background Long non-coding ribonucleic acids (lncRNAs) are believed to play crucial roles in cardiovascular diseases; however, details of the underlying mechanisms by which this occurs remain unclear. Methods A mouse heart failure (HF) model was established using isoproterenol (ISO), and confirmed by immunostaining and echocardiography. RNA-sequencing was performed to screen the differential lncRNA expression profiles and heart failure relative lncRNA (HFRL) was selected as the target which was validated by quantitative real-time polymerase chain reaction (qRT-PCR). In HL-1 cells, the cardiac function, inflammatory, and fibrosis-related genes expression changes were examined by qRT-PCR after silencing of HFRL by lentivirus. Meanwhile, Cell Counting Kit-8 (CCK-8) assays were used to detect the effects of HFRL on the cell proliferation and viability. Reactive oxygen species (ROS) assays were also used to explore the role of HFRL in oxidative damage. Next, bioinformatics analysis was conducted to predict the potential binding microRNAs (mmu-miR-149-5p) to HFRL, which was confirmed by RNA-pulldown assays. The target gene of miR-149-5p was also predicted and further validated by Dual-luciferase reporter assays, qRT-PCR, and western blot. To investigate the synergistic regulatory effect of HFRL and miR-149-5p, HL-1 cells were infected with the lentivirus of HFRL with or without simultaneous knockdown of miR-149-5p. Then, qRT-PCR and western blot were used to examine cardiac function, inflammatory, and fibrosis-related gene expression changes, respectively. In HL-1 cells, CCK-8 assays were performed to detect the proliferation and viability. ROS assays were used to explore the oxidative damage. Results The administration of ISO induced mice fibrosis, inflammation, and HF. The in-vitro results showed that knockdown of HFRL suppressed cardiomyocyte proliferation and viability, attenuated inflammatory, cardiac function, and fibrosis-related gene expression, and promoted oxidative damage. HFRL was found to bind to mmu-miR-149-5p and inversely target the 3'-untranscripted region of the collagen 22A1 gene. Thus, HFRL affected cardiomyocyte inflammation, proliferation, viability, oxidative damage, and pro-fibrotic function via sequestration to miR-149-5p. Conclusions The HFRL/miR-149-5p axis plays an important role in regulating cardiac inflammation, proliferation, and fibrosis via a synergistic effect, which suggests that HFRL might be a novel target for HF.

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Socioeconomic Determinants of Health and Cardiovascular Outcomes in Women

Cited by 59 publications

References 79 publications

Sex‐Related Differences in Genetic Cardiomyopathies

Sex‐Related Differences in Genetic Cardiomyopathies

Socioeconomic characteristics of African American women attending community blood pressure screenings

Enhancement of LncRNA-HFRL expression induces cardiomyocyte inflammation, proliferation, and fibrosis via the sequestering of miR-149-5p-mediated collagen 22A inhibition

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