The paper attempts to identify and define the poorly developed (problem) areas in the Republic of Srpska (a Bosnia and Herzegovina entity), the specificities of their geo-systems, the fundamental development issues and comparative development benefits, with an aim to minimize the spatial (regional) development disparities and reach the territorial cohesion and sustainable development. In order to single out the problem areas, it is necessary to define an adequate development strategy, i.e. to plan and conduct the crucial development processes based upon the identification and valorization of autochthone development potentials. The constant evident spatial-development disparity, the social-economic issues and differences, and the problems of population movement and distribution are all crucial issues of the Republic of Srpska and Bosnia and Herzegovina sustainable development.