Socioeconomic challenges of chronic suppurative otitis media management in state tertiary health facility in Nigeria

Afolabi, OA; Fadare, Joseph; Omokanye, H.K.; Olatoke, Fatai; Odi, Temitope O; Saka, MJ; Adaranijo, R.K.

doi:10.1016/j.ejenta.2013.07.002

Cited by 9 publications

(11 citation statements)

References 12 publications

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“…Whereas, the bacteria commonly isolated from patients with acute otitis media (AOM) are Moraxella catarrhalis and Streptococcus pneumonia , Haemophilus influenzae 5 . Additionally, the P. aeruginosa had been seen as a notorious pathogen in the hospital too 6, 7. Certainly, the ability to form biofilm by these organisms contributes to their frequency in CSOM 8 .…”

Section: Introductionmentioning

confidence: 99%

Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital

Sahu

Swain

2019

World j. otorhinolaryngol.-head neck surg.

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Introduction Chronic suppurative otitis media (CSOM) is a common problem in worldwide and untreated CSOM leads to fatal complications like facial nerve paralysis, lateral sinus thrombosis, labyrinthitis, meningitis and brain abscess in developing country like India. Objective To isolate causative bacteria and antibiotic sensitivity pattern for CSOM and to know the prevalence of extended spectrum beta lactamases (ESBL) and Metallobetalactamases (MBL) in CSOM patients. Methods A total of 500 ear swabs of clinical suspected CSOM patients were cultured on specific cultured medium and identified the bacteria with conventional methods. Then all the identified bacteria were subjected with specific antibiotics by the Kirby–Bauer's method to know the resistance pattern of antibiotics. ESBL and MBL strains were detected by double disc diffusion test. Results A total of 384 bacteria were isolated from 500 CSOM patients, among them 86 P. aeruginosa (22.40%), 112 Staphylococcus aureus (29.17%), 53 A. baumannii (13.80%), 32 E. aerogenes (18%), 26 C. freundii (6.77%), 24 K. oxytoca (6.25%), 23 P. vulgaris (5.99%), 18 K. pneumoniae (4.69%) and 10 P. mirabilis (2.60%) identified with conventional methods. From antibiotic disc diffusion methods 74.22% ESBL strains and 9.90% MBL strains were documented. Multidrug resistant strains of P. aeruginosa (86/384,22.40%) were more prevalent than those of S. aureus (112/384,29.17%) and other bacteria in ear discharges. Imipenem and vancomicin could control to gram negative bacteria and gram positive bacteria respectively. Conclusion Continuous and periodic evaluation of microbiological profile and antimicrobial sensitivity pattern of bacterial is essential for optimum management of CSOM patients.

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Section: Introductionmentioning

confidence: 99%

Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital

Sahu

Swain

2019

World j. otorhinolaryngol.-head neck surg.

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“…In addition, chronic infection of the middle ear can lead to edema of the middle-ear lining and possibly ossicular chain disruption that further aggravates the problem of hearing loss in CSOM patients 14 . CSOM remains a serious public health concern in both developing regions such as in Africa, Asia, and Latin America, as well as in developed countries 15 . The World Health Organization (WHO) reports that about 65 to 330 million people worldwide develop CSOM and approximately, 60% will have the hearing dysfunction 16 .…”

Section: Introductionmentioning

confidence: 99%

Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway

Mittal

Debs

Patel

et al. 2019

Sci Rep

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Chronic suppurative otitis media (CSOM) is one of the most common infectious diseases of the middle ear especially affecting children, leading to delay in language development and communication. Although Staphylococcus aureus is the most common pathogen associated with CSOM, its interaction with middle ear epithelial cells is not well known. In the present study, we observed that otopathogenic S. aureus has the ability to invade human middle ear epithelial cells (HMEECs) in a dose and time dependent manner. Scanning electron microscopy demonstrated time dependent increase in the number of S. aureus on the surface of HMEECs. We observed that otopathogenic S. aureus primarily employs a cholesterol dependent pathway to colonize HMEECs. In agreement with these findings, confocal microscopy showed that S. aureus colocalized with lipid rafts in HMEECs. The results of the present study provide new insights into the pathogenesis of S. aureus induced CSOM. The availability of in vitro cell culture model will pave the way to develop novel effective treatment modalities for CSOM beyond antibiotic therapy.

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“…There is a need for capacity building to reduce the burden as well as the associated risk. 5 The HUNT study indicates that CSOM and recurrent acute otitis media in childhood are associated with adult hearing loss, underlining the importance of optimal treatment in these conditions. It suggests that ears with a subsequent hearing loss, after otitis media in childhood age at a faster rate than those without.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of chronic suppurative otitis media in school going children in Bareilly (Uttar Pradesh)

Singhal

Agrawal

Agrawal³

2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Chronic suppurative otitis media (CSOM) is one of the most common ear diseases in the South East Asia having a prevalence of approximately 5.2% in the general population. The objective of the study was to find the prevalence of CSOM in school going children in urban field practice area of tertiary care hospital in Bareilly (UP). Methods: Cross-sectional study involving 495 schools going children in Bareilly district of Uttar Pradesh. Results: The prevalence of CSOM was found to be 6.46%, with tubotympanic type constituting majority 81.25% trailed by atticoantral type 18.75%. Most patients presented with moderate hearing impairment (43.75%) and mild hearing impairment (31.25%). With respect to socioeconomic groups, upper lower, groups had 40.63%, and lower group had 34.37% prevalence. Conclusions: Improvement of health care facilities and awareness among health-care providers would definitely be helpful in reducing the prevalence of ear diseases in the developing countries like India.

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Socioeconomic challenges of chronic suppurative otitis media management in state tertiary health facility in Nigeria

Cited by 9 publications

References 12 publications

Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital

Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital

Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway

Prevalence and determinants of chronic suppurative otitis media in school going children in Bareilly (Uttar Pradesh)

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