Socioeconomic and geographic variations in the prevalence, awareness, treatment and control of dyslipidemia in middle-aged and older Chinese

Song, Peige; Zha, Mingming; Yang, Xiangming; Xu, Yan; Wang, Hanyu; Fang, Zhe; Yang, Xiangrong; Xia, Wei; Zeng, Chengbo

doi:10.1016/j.atherosclerosis.2019.01.005

Cited by 43 publications

(52 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present results on awareness, treatment and control were higher compared with previous studies in China 9,22 Further, we recorded higher awareness and treatment, but lower control values for dyslipidemia compared with other studies. 7,8 The low level of control observed in the current study could partly be explained by the low treatment value observed despite evidences available on the therapeutic use of statins, 22,23 or due to poor adherence to medications. 24 The low level of control seen may also reveal some level of ineffectiveness in the current treatment approaches.…”

Section: Discussionmentioning

confidence: 61%

“…A study determined that stroke prevalence was signi cantly higher in the northern parts of China, 41 and living in the north was associated with high dyslipidemia prevalence. 8,42 We speculate that, the high prevalence of stroke and dyslipidemia found in the north could positively affect inhabitants' behaviors towards treatment and yield favorable results. We showed that lower likelihoods of dyslipidemia awareness, treatment, and control were related to living in the stroke belt region of China.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Awareness, treatment, control, and determinants of dyslipidemia among adults in China: results from the China National Stroke Screening and Prevention Project (CNSSPP)

Opoku

Gan

Addo-Yobo

et al. 2020

Preprint

View full text Add to dashboard Cite

Background:Effective management of dyslipidemia could play a vital role in the control of cardiovascular diseases. This study aimed to determine the awareness, treatment, control, and determinants of dyslipidemia in middle-aged and older Chinese adults in China. METHODS Using data from the 2015 CNSSPP, a nationally representative sample of 135,403 Chinese adults aged over 40 years were included in the cross-sectional analysis. Dyslipidemia was defined according to the 2016 Chinese guidelines for the management of dyslipidemia in adults. Models were constructed to adjust for sociodemographic, clinical and behavioral characteristics with bivariate and multivariable logistic regressions. RESULTSOverall, 51.1% of the subjects were women. Sixty-four percent (36,958/57760) were aware of their condition, of whom 18.9% (6993/36958) received treatment, and of whom 7.3 % (504 /6993) had controlled lipids. Women versus men had higher proportions of awareness, treatment, and control (69.2% vs. 58.3%, 63.8% vs.64.1% and 7.7% vs.7.0%; p< 0.001), respectively. Dyslipidemia treatment was higher in men from rural than urban areas (15.4% vs. 10.6%; p<0.001). Most subjects (94.3%), had dyslipidemia in their family. The proportion of awareness was higher among urban compared to rural residents across all the socioeconomic regions: low-income (68.8% vs. 60.4%), middle-income (69.4% vs.63.9%), and high-income (66% vs.58.6%), respectively (all p< 0.001). In the multivariable analysis, significant associations were found between awareness and women, urban residents, having a family history, and central obesity. Being a woman, having a personal history of stroke or CHD, being a drinker, having health insurance, and persons who lived in high-income regions had higher odds of receiving treatment. Adults in the 50 - 59 years age group, having health insurance, central and general obesity, living in a stroke belt or northern zone, urban area, and women showed statistically significant relationships with control. CONCLUSIONS Dyslipidemia awareness was moderately high, but treatment and control were low. Improvements in education programs and therapeutic management may be necessary to promote and optimize the management of dyslipidemia.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 97%

Awareness, treatment, control, and determinants of dyslipidemia among adults in China: results from the China National Stroke Screening and Prevention Project (CNSSPP)

Opoku

Gan

Addo-Yobo

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Hypertension was de ned as systolic pressure ≥140 mm Hg or diastolic pressure ≥90 mm Hg or current use of antihypertensive medication, [17] and high cholesterol as TC ≥6.22 mmol/L or having received treatment for high cholesterol, [18] diabetes as self-reported history of diabetes diagnosed by a physician or FBG ≥7.0 mmol/L or current use of blood glucose-lowering medication. [19] "Awareness" of a disease was referred to a self-reported physician diagnosis of the disease before the examination.…”

Section: Data Collection and Assessmentsmentioning

confidence: 99%

“…[17] "Treatment" was referred to self-reported use of medications for a certain disease, and the treatment rate as the proportion of persons who were taking medications among people with the disease. [19] The control rate of hypertension, diabetes, and high cholesterol was de ned as the proportion of achieving the goal of blood pressure <140/90 mm Hg, [17] TC <6.22 mmol/L, [18] and FBG <7.0 mmol/L, [19] respectively, among people who took the corresponding medications (control A) or among people who had the corresponding disease (control B).…”

Section: Data Collection and Assessmentsmentioning

confidence: 99%

See 1 more Smart Citation

Gender Disparities in Cardiovascular Health Metrics among Rural-Dwelling Older Adults in China: a population-based study

Han

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Cardiovascular health (CVH) metrics among Chinese older adults are poorly understood. We investigated gender disparities in CVH metrics and their management among rural-dwelling older adults in China.Methods: This community-based study included 5026 participants (age ≥65 years; 57.2% women) in the baseline survey of a multimodal intervention study in rural China. Data were collected through face-to-face interviews, clinical examinations, and laboratory tests in March-September 2018. We defined six CVH metrics (three behavioral factors—smoking, body mass index, and physical activity; three biological factors—blood pressure, total cholesterol, and blood glucose) following the modified American Heart Association’s recommendations. We performed descriptive analysis separately for men and women.Results: Of all participants, only 0.8% achieved ideal levels in all six CVH metrics. Men were more likely than women to have ideal levels in all CVH metrics but smoking. Women had higher prevalence of ideal global CVH metrics (9.7% in women vs. 7.8% in men) and behavioral CVH metrics (18.3% vs. 9.5%) (p<0.001), whereas men had higher prevalence of ideal biological CVH metrics (5.4% in men vs. 3.5% in women, p<0.001). The prevalence of ideal global and behavioral CVH metrics increased with age in both women and men (p for trend<0.001). Women were more likely to be aware of their hypertension and diabetes, and to receive antihypertensive treatment, while men were more likely to achieve the goal of high cholesterol treatment (p<0.05).Conclusions: The CVH metrics among older adults living in the rural communities in China are characterized by an extremely low proportion of optimal global CVH metrics and distinct gender differences, alongside poor management of major biological risk factors.Trial registration: ChiCTR1800017758.

show abstract

Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population‐based study

Ren,

Li,

Tian

et al. 2023

Alzheimer's & Dementia

View full text Add to dashboard Cite

INTRODUCTIONTo examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)‐related plasma biomarkers among older adults.METHODSThis population‐based study included 5432 participants (age ≥60 years); of these, plasma amyloid beta (Aβ), total tau, and neurofilament light chain (NfL) were measured in a subsample (n = 1412). We used hierarchical clustering to generate five multimorbidity clusters from 23 chronic diseases. We diagnosed dementia and MCI following international criteria. Data were analyzed using logistic and linear regression models.RESULTSThe number of chronic diseases was associated with dementia (multivariable‐adjusted odds ratio = 1.22; 95% confidence interval [CI] = 1.11 to 1.33), AD (1.13; 1.01 to 1.26), vascular dementia (VaD) (1.44; 1.25 to 1.64), and non‐amnestic MCI (1.25; 1.13 to 1.37). Metabolic cluster was associated with VaD and non‐amnestic MCI, whereas degenerative ocular cluster was associated with AD (p < 0.05). The number of chronic diseases was associated with increased plasma Aβ and NfL (p < 0.05).DISCUSSIONMultimorbidity burden and clusters are differentially associated with subtypes of dementia and MCI and AD‐related plasma biomarkers in older adults.Highlights We used hierarchical clustering to generate five clusters of multimorbidity. The presence and load of multimorbidity were associated with dementia and mild cognitive impairment. Multimorbidity clusters were differentially associated with subtypes of dementia and Alzheimer's disease plasma biomarkers.

show abstract

Socioeconomic and geographic variations in the prevalence, awareness, treatment and control of dyslipidemia in middle-aged and older Chinese

Cited by 43 publications

References 33 publications

Awareness, treatment, control, and determinants of dyslipidemia among adults in China: results from the China National Stroke Screening and Prevention Project (CNSSPP)

Awareness, treatment, control, and determinants of dyslipidemia among adults in China: results from the China National Stroke Screening and Prevention Project (CNSSPP)

Gender Disparities in Cardiovascular Health Metrics among Rural-Dwelling Older Adults in China: a population-based study

Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population‐based study

Contact Info

Product

Resources

About