Background and Objectives: The mortality profile is an important health indicator and its analysis allows researchers to identify inequalities and trends that require specific actions and studies. This study sought to identify the mortality profile in women of childbearing age in the municipality of Santa Cruz do Sul, in the period between 2013 and 2017. Methods: This is an epidemiological study, with a quantitative approach, following an exploratory descriptive and documentary research method. The data were obtained from the analysis of the Death Declaration records in the Mortality Information System of the municipality. Results: The mortality profile in women of childbearing age was white skin color, age between 40 and 49 years, with 8 to 11 years of schooling, who worked and lived in urban areas. Neoplasms were the main cause of death, especially in bronchi and lungs. Conclusion: The data show the importance of investing in women’s health and cancer prevention, especially in the bronchi and lungs.