Sociodemographic, Electrophysiological, and Biochemical Profiles in Children with Attention Deficit Hyperactivity Disorder and/or Epilepsy

Naby, Sameh A Abd El; Naguib, Yahya M.

doi:10.1155/2018/8932817

Cited by 14 publications

(10 citation statements)

References 44 publications

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“…In accordance with previous studies, we observed sex differences in our results regarding inattention, hyperactivity/impulsivity and ADHD symptoms. Differences have been reported previously [61][62][63], with the diagnosis of ADHD being more common in male children and adolescents, with a male-to-female ratio ranging from 2:1 to 10:1 [64]. In line with this, in the present study, boys had more symptoms than girls.…”

Section: Sex Differencessupporting

confidence: 88%

Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA–INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study

Santa‐Marina

Lertxundi

Andiarena

et al. 2020

IJERPH

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Ferritin status during prenatal brain development may influence the risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. We investigated the association of maternal ferritin in pregnancy and ADHD-like symptoms in offspring. A total of 1095 mother-child pairs from three birth cohorts of the INMA Project (Spain) were studied. Maternal plasma ferritin in pregnancy was measured at 11.57 weeks of gestation. Children′s ADHD-like symptoms at ages 4–5 years were assessed using the ADHD Rating Scale-IV. The count model of the zero-inflated Poisson regression model showed a significant inverse association between ferritin (continuous variable) and inattention, β = −0.19 (−0.32, −0.07), for boys. Comparing ferritin level by tertiles, significant differences were observed between the first tertile ([1.98, 20.92]) and the second ([20.92, 38.79]) and third tertiles ([38.79, 216.5]) (mg/L).The number of symptoms was lower for those in the third tertile, β = −0.3 (−0.55, −0.5), and for those in the second one, β = −0.37 (−0.6, −0.14). The model stratification by sex also showed this inverse association for boys only, β = −0.21 (−0.34, −0.08). No associations were found between ferritin level and hyperactivity or total ADHD symptoms. High ferritin levels during pregnancy show a protective association with child inattentive-type ADHD symptoms.

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Section: Sex Differencessupporting

confidence: 88%

Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA–INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study

Santa‐Marina

Lertxundi

Andiarena

et al. 2020

IJERPH

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“…Similarly, Abd El Naby et al verified that there was a strong significant correlation between PedsQL scores with IQs (p value = 0.001) [17]. Other studies have confirmed that ADHD with epilepsy is inversely correlated with the QOL and that treating ADHD significantly improves the QOL of CWE [73,74].…”

Section: Discussionmentioning

confidence: 88%

“…Attention-deficit/hyperactivity disorder (ADHD) is one of the most widespread disorders in CWE [15,16]. ADHD is generally characterized by persistent inattention, hyperactivity, and impulsivity [17]. Furthermore, several studies found that ADHD children may have electroencephalogram (EEG) abnormalities such as interictal epileptiform discharges (IEDs) or localization of IEDs foci [18,19].…”

Section: Introductionmentioning

confidence: 99%

Comparison of cognitive function, socioeconomic level, and the health-related quality of life between epileptic patients with attention deficit hyperactivity disorder and without

Ahmed

Darwish

Khalifa

et al. 2020

Middle East Curr Psychiatry

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Background Epilepsy is one of the most common neurological conditions. Attention deficit hyperactivity disorder (ADHD) in children with epilepsy proves to be very common. Both epilepsy and ADHD impair quality of life. We aimed to evaluate cognitive function, socioeconomic level, and quality of life (QOL) among children with ADHD and epilepsy. A total of 100 children were divided into 5 groups (20 children/group) as (I) epilepsy, (II) ADHD with epilepsy, (III) ADHD with EEG changes, (IV) ADHD without EEG changes, and (V) control. Children aged between 6 and 11 years were recruited for this study. Early Childhood Epilepsy Severity Scale (E-Chess), Conners’ Parent Rating Scale (CPRS), Wechsler Intelligence Scale for Children-3rd edition (WISC-III), socioeconomic scale for assessment of social burden and socioeconomic classes, and PedsQL (quality of life measure) assessed. Results Children with ADHD and epilepsy had the lowest PedsQL total scores and lower scores than other groups especially in performance IQ score. The highest percentage of low socioeconomic class (25%) was observed in the group of ADHD with epilepsy and the group of epilepsy. Conclusion ADHD with epilepsy is associated with low performance IQ, poor socioeconomic level, and quality of life. Pediatric Quality of Life Inventory scores show significant correlation with total IQ score in the group of ADHD with epilepsy.

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“…4 of these studies found that there were no significant differences between sex and ADHD symptoms [ 33 , 39 , 42 , 47 ]. 5 studies found that males had more ADHD symptoms than females [ 11 , 28 , 34 , 41 , 50 ]. One study [ 26 ] compared iron status (iron sufficient, ID without anemia, ID anemia) and sex, and found a statistically significant difference (p<0.001) between the aforementioned groups.…”

Section: Resultsmentioning

confidence: 99%

“…Apart from 4 ADHD studies which measured only SF as a primary iron marker [ 41 – 43 , 46 ] and 1 ADHD study which measured only SF and SI [ 50 ], all studies measured both iron-related and RBC-related markers for ID. A significant association of SF, but not of RBC-related or other iron markers was found in 9 ADHD [ 14 , 28 – 32 , 35 , 37 , 39 ] and 2 ASD studies [ 17 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

Iron deficiency and common neurodevelopmental disorders—A scoping review

McWilliams

Singh²,

Leung³

et al. 2022

PLoS ONE

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Background A wealth of human and experimental studies document a causal and aggravating role of iron deficiency in neurodevelopmental disorders. While pre-, peri-, and early postnatal iron deficiency sets the stage for the risk of developing neurodevelopmental disorders, iron deficiency acquired at later ages aggravates pre-existing neurodevelopmental disorders. Yet, the association of iron deficiency and neurodevelopmental disorders in childhood and adolescence has not yet been explored comprehensively. In this scoping review, we investigate 1) the association of iron deficiency in children and adolescents with the most frequent neurodevelopmental disorders, ADHD, ASD, and FASD, and 2) whether iron supplementation improves outcomes in these disorders. Method Scoping review of studies published between 1994 and 2021 using “iron deficiency / iron deficiency anemia” AND “ADHD” OR “autism” OR “FASD” in four biomedical databases. The main inclusion criterion was that articles needed to have quantitative determination of iron status at any postnatal age with primary iron markers such as serum ferritin being reported in association with ADHD, ASD, or FASD. Results For ADHD, 22/30 studies and 4/4 systematic reviews showed an association of ADHD occurrence or severity with iron deficiency; 6/6 treatment studies including 2 randomized controlled trials demonstrated positive effects of iron supplementation. For ASD, 3/6 studies showed an association with iron deficiency, while 3/6 and 1/1 systematic literature review did not; 4 studies showed a variety of prevalence rates of iron deficiency in ASD populations; 1 randomized controlled trial found no positive effect of iron supplementation on behavioural symptoms of ASD. For FASD, 2/2 studies showed an association of iron deficiency with growth retardation in infants and children with prenatal alcohol exposure. Conclusion Evidence in favor of screening for iron deficiency and using iron supplementation for pediatric neurodevelopmental disorders comes primarily from ADHD studies and needs to be further investigated for ASD and FASD. Further analysis of study methodologies employed and populations investigated is needed to compare studies against each other and further substantiate the evidence created.

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Sociodemographic, Electrophysiological, and Biochemical Profiles in Children with Attention Deficit Hyperactivity Disorder and/or Epilepsy

Cited by 14 publications

References 44 publications

Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA–INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study

Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA–INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study

Comparison of cognitive function, socioeconomic level, and the health-related quality of life between epileptic patients with attention deficit hyperactivity disorder and without

Iron deficiency and common neurodevelopmental disorders—A scoping review

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