Sociodemographic Disparities in Presentation and Survival of Pediatric Bone Cancers

Goulding, DeLayna; Arguinchona, Lauren; Anderson-Mellies, Amy; Mikkelsen, Margit; Eguchi, Megan; Marinoff, Hannah; Zahedi, Shadi; Ribeiro, Karina Braga; Cockburn, Myles; Galindo, Carlos Rodriguez; Green, Adam L.

doi:10.1097/mph.0000000000002531

Cited by 5 publications

(13 citation statements)

References 30 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, adolescents with metastatic disease at presentation had higher odds of mortality with lower SES than those considered of higher SES. 12 Similar results have been reported in other studies using the NCDB data. 37 Additionally, age-related disparities in the primary site of disease and rate of metastases have been reported, which is compounded by established racial ethnic disparities, in the literature.…”

Section: Essupporting

confidence: 89%

“…For adolescents with ES, racial disparities in survival have been reported with better survival reported for “White” adolescents. Furthermore, adolescents with metastatic disease at presentation had higher odds of mortality with lower SES than those considered of higher SES 12 . Similar results have been reported in other studies using the NCDB data 37 .…”

Section: Disparities In Primary Bone Malignanciessupporting

confidence: 88%

“…Similarly among pediatric patients specifically, “Hispanics” and residents of “high language isolation” were more likely to present with advanced stage of disease. Pediatric patients with “public insurance” had increased odds of mortality when compared to those with “private insurance.” Adolescents with metastatic disease residing in counties with “lower education level” also had higher odds of mortality 12 …”

Section: Disparities In Primary Bone Malignanciesmentioning

confidence: 99%

“…Adolescents with metastatic disease residing in counties with "lower education level" also had higher odds of mortality. 12…”

Section: Disparities In Primary Bone Malignancies 41 | Osteosarcomamentioning

confidence: 99%

“…8 Monitoring and reduction of health care disparities has been a long-term goal of current the US health policy. 9 There have been reports implicating racial/ethnic, 10,11 socioeconomic 12 and insurance-related 13 disparities in survival among patients primary bone malignancies and soft tissue sarcomas utilizing the National Cancer Institute's (NCI) Surveillance, Epidemiology and End Result (SEER). 14 Such reports 15,16 have also emanated from American College of Surgeon's (ACS) National Cancer Database (NCDB).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Socioeconomic disparities in musculoskeletal oncology

Jawad

Theriault

Thorpe

et al. 2023

Journal of Surgical Oncology

View full text Add to dashboard Cite

Musculoskeletal oncology is a clinical specialty dealing with a diverse population of patients with metastatic bone disease, hematological malignancies with musculoskeletal manifestations, primary bone malignancies and soft tissue sarcomas. There are wide‐spread disparities including socioeconomic (SES) and insurance‐related disparities reported in the literature. In this review, we'll summarize the disparities surrounding the musculoskeletal oncology.

show abstract

Section: Essupporting

confidence: 89%

Section: Disparities In Primary Bone Malignanciessupporting

confidence: 88%

Section: Disparities In Primary Bone Malignanciesmentioning

confidence: 99%

“…Adolescents with metastatic disease residing in counties with "lower education level" also had higher odds of mortality. 12…”

Section: Disparities In Primary Bone Malignancies 41 | Osteosarcomamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Socioeconomic disparities in musculoskeletal oncology

Jawad

Theriault

Thorpe

et al. 2023

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Early death from childhood cancer: First medical record‐level analysis reveals insights on diagnostic timing and cause of death

Lind,

Molina,

Mellies

et al. 2023

Cancer Medicine

Self Cite

View full text Add to dashboard Cite

BackgroundApproximately 7.5% of pediatric cancer deaths occur in the first 30 days post diagnosis, termed early death (ED). Previous database‐level analyses identified increased ED in Black/Hispanic patients, infants, late adolescents, those in poverty, and with specific diagnoses. Socioeconomic and clinical risk factors have never been assessed at the medical record level and are poorly understood.MethodsWe completed a retrospective case–control study of oncology patients diagnosed from 1995 to 2016 at Children's Hospital Colorado. The ED group (n = 45) was compared to a non‐early death (NED) group surviving >31 days, randomly selected from the same cohort (n = 44). Medical records and death certificates were manually reviewed for sociodemographic and clinical information to identify risk factors for ED.ResultsWe identified increased ED risk in central nervous system (CNS) tumors and, specifically, high‐grade glioma and atypical teratoid/rhabdoid tumor. There was prolonged time from symptom onset to seeking care in the ED group (29.4 vs. 9.8 days) with similar time courses to diagnosis thereafter. Cause of death was most commonly from tumor progression in brain/CNS tumors and infection in hematologic malignancies.ConclusionsIn this first medical record‐level analysis of ED, we identified socioeconomic and clinical risk factors. ED was associated with longer time from first symptoms to presentation, suggesting that delayed presentation may be an addressable risk factor. Many individual patient‐level risk factors, including socioeconomic measures and barriers to care, were unable to be assessed through record review, highlighting the need for a prospective study to understand and address childhood cancer ED.

show abstract

Disparities in incidence and survival for patients with Ewing sarcoma in Florida

Dhir,

Rahul,

Liu

et al. 2024

Cancer Medicine

View full text Add to dashboard Cite

BackgroundEwing sarcoma (ES) is a malignant bone tumor most commonly affecting non‐Hispanic White (NHW) adolescent males, though recognition among Hispanic individuals is rising. Prior population‐based studies in the United States (US), utilizing Surveillance, Epidemiology, and End Results (SEER) have shown higher all‐cause mortality among White Hispanics, Blacks, and those of low socioeconomic status (SES). Florida is not part of SEER but is home to unique Hispanic populations including Cubans, Puerto Ricans, South Americans that contrasts with the Mexican Hispanic majority in other US states. This study aimed to assess racial/ethnic disparities on incidence and survival outcomes among this diverse Florida patient population.MethodologyOur study examined all patients diagnosed with osseous ES (2005–2018) in Florida (n = 411) based on the state's population‐based cancer registry dataset. Florida Age‐adjusted Incidence Rates (AAIRs) were computed by sex and race‐ethnicity and compared to the equivalent populations in SEER. Cause‐specific survival disparities among Florida patients were examined using Kaplan–Meier analysis. Univariable and multivariable analyses using Cox regression were performed for race/ethnicity, with adjustment for age, sex, year of diagnosis, site of disease, staging, SES, and insurance type.ResultsThere was a significantly higher incidence of osseous ES in Florida Hispanic males (AAIR 2.6/1,000,000); (95% CI: 2.0–3.2 per 1,000,000; n = 84) compared to the SEER Hispanic males (AAIR 1.2/1,000,000;1.1–1.4 per 1,000,000; n = 382). Older age, distant metastasis, lack of chemotherapy or surgical resection were statistically significant determinants of poor survival while SES, insurance status and race‐ethnicity were not. However, among nonmetastatic ES, Florida Hispanics had an increased risk of death compared to Florida NHW (adjusted Hazard Ratio 2.32; 95%CI: 1.20–4.46; p = 0.012).ConclusionsFlorida Hispanic males have a higher‐than‐expected incidence of osseous ES compared to the US. Hispanics of both sexes show remarkably worse survival for nonmetastatic disease compared to NHW. This disparity is likely multifactorial and requires further in‐depth studies.

show abstract

Sociodemographic Disparities in Presentation and Survival of Pediatric Bone Cancers

Cited by 5 publications

References 30 publications

Socioeconomic disparities in musculoskeletal oncology

Socioeconomic disparities in musculoskeletal oncology

Early death from childhood cancer: First medical record‐level analysis reveals insights on diagnostic timing and cause of death

Disparities in incidence and survival for patients with Ewing sarcoma in Florida

Contact Info

Product

Resources

About