Sociodemographic correlates of health-related quality of life in pediatric epilepsy

Psychiatric and Medical Comorbidity and Quality of Life Outcomes in Childhood-Onset Epilepsy

“…16 Although several cross-sectional studies have revealed a negative association for comorbid conditions with HRQoL in CWE, these reports differ from the results of our analysis in that they used a parent proxy-report of HRQoL only, included children with predominantly active epilepsy, or analyzed a limited or unspecified number of chronic comorbidities. 30,[35][36][37]40,[43][44][45][46] Psychiatric comorbidity is significantly associated with worse HRQoL among adults with epilepsy, and congruent with our results in children, this association is stronger than seizure control status. [21][22][23][24][25][26] Our results are, therefore, concordant with the notion that factors beyond seizures and epilepsy might be driving poor quality-of-life outcomes in CWE.…”

“…[30][31][32][33][34][35][36][37][38][39][40][41][42] Although a limited number of studies have revealed a negative association of comorbidity with HRQoL in CWE, no studies have been performed to examine the independent effects of chronic comorbidities, including psychiatric and neurodevelopmental disorders, on HRQoL in CWE nearly a decade after childhoodonset epilepsy. 30,[35][36][37]40,[43][44][45][46] In a community-based study of children with newly diagnosed epilepsy followed prospectively, we examined the relative impacts of 5-year remission and "complicated" epilepsy (secondary to an underlying neurologic insult or epileptic encephalopathy) status, in addition to chronic comorbidity (eg, psychiatric diagnosis, neurodevelopmental disorders, migraine, chronic medical conditions) to determine if they were differentially associated with HRQoL at follow-up during adolescence. Given evidence of persistent poor long-term psychosocial outcomes among children with childhoodonset epilepsy, even in the setting of seizure remission, in conjunction with evidence that psychiatric comorbidity is more strongly associated with HRQoL than epilepsy-related factors among adults with epilepsy, we hypothesized that psychiatric or neurodevelopmental comorbidity would be more strongly associated with worse long-term HRQoL than 5-year remission status.…”

Interdependence of marital status and clinical characteristics of morbidity with health-related quality of life among low back pain patients

“…This finding is supported by a study reporting that chronicity is one of the insignificant factors posited to influence delays in seeking treatment and, consequently, to adversely affect HRQoL [27]. Many studies have reported that CCM are significant correlates of HRQoL in patients with LBP [9,17,21,23,24], thereby contrasting with the finding of this study where it was found to be insignificant. These contrasting findings might be a result of variation in study methodology including subject characteristics, differences in measuring instruments of HRQoL, etc.…”

“…Several demographic and clinical factors are said to influence HRQoL. Some of the implicated clinical factors include physical, psychological, acute or chronic clinical conditions and pain intensity [9,23,24], and the demographic factors are age, gender, ethnicity, marital status and socioeconomic status [8,12,16]. It is worth noting that gradients of LBP are never the same across communities in the same country and neither are they the same across countries.…”

Impact of infantile short bowel syndrome on long-term health-related quality of life: a cross-sectional study

“…A general questionnaire was used to obtain general data such as socioeconomic status (SES) based on parents' occupation and education [22]. Studies on chronic diseases have indicated that HRQoL is influenced by age, sex, and SES, with disadvantaged groups typically reporting lower HRQoL [23][24][25][26][27]. Studies in healthy populations also indicate that SES is inversely associated with children's HRQoL [28][29][30][31].…”