Sociodemographic, clinical and laboratory factors on admission associated with COVID-19 mortality in hospitalized patients: A retrospective observational study

Abstract

Background To identify and quantify associations between baseline characteristics on hospital admission and mortality in patients with COVID-19 at a tertiary hospital in Spain. Methods and findings This retrospective case series included 238 patients hospitalized for COVID-19 at Hospital Universitario Clínico San Cecilio (Granada, Spain) who were discharged or who died. Electronic medical records were reviewed to obtain information on sex, age, personal antecedents, clinical features, findings on physical examination, and laboratory results for each patient. Associations between mortality and baseline characteristics were estimated as hazard ratios (HR) calculated with Cox regression models. Series mortality was 25.6%. Among patients with dependence for basic activities of daily living, 78.7% died, and among patients residing in retirement homes, 80.8% died. The variables most clearly associated with a greater hazard of death were age (3% HR increase per 1-year increase in age; 95%CI 1-6), diabetes mellitus (HR 2.42, 95%CI 1.43-4.09), SatO 2 / FiO 2 ratio (43% HR reduction per 1-point increase; 95%CI 23-57), SOFA score (19% HR

Correlation between hospitalized patients’ demographics, symptoms, comorbidities, and COVID-19 pandemic in Bahia, Brazil

“…Liu et al [21], in a research to determine the risk factors for severe COVID-19, report that fever, cough and fatigue appear as the main symptoms among the participants, with fever being the most common initial symptom (92.3%). Rivera-Izquierdo et al [22] complement that in patients admitted for COVID-19 at Hospital Universitario Clínico San Cecilio, Spain, the most frequent clinical picture was also due to low fever (89.5%) and dry cough (80.7%), followed by general malaise (63.5%), dyspnea (61.3%) and tiredness (59.2%).…”

The Role of Health Preconditions on COVID-19 Deaths in Portugal: Evidence from Surveillance Data of the First 20293 Infection Cases

“…The vulnerability of elderly individuals is illustrated in recent studies. A retrospective observational study investigating mortality in hospitalized patients with COVID-19 registered the great vulnerability of patients residing in retirement homes, with older age independently associated with mortality when adjusted for other variables of interest [22]. On the opposite residence condition, the shape of COVID-19 vulnerability was estimated based on a random infection of 10% of the population living in private households (excluding individuals living in retirement homes) of 81 countries [27].…”

“…Still, the link between older individuals and the likelihood to develop severe and critical cases of COVID-19 has been made before, either due to immunosenescence, malnutrition, or ignoring more easily the early symptoms and consequently missing the best time to seek medical advice [ 20 , 21 ]. Furthermore, several studies registered an important association between increased age and COVID-19 severity/fatality [ 22 , 23 , 24 , 25 , 26 ]. The vulnerability of elderly individuals is illustrated in recent studies.…”

Knowledge management in pandemics. A critical literature review

“…This topic is another key objective during disease outbreak. Actually COVID-19 is demonstrating how hospitals and health-care residence can be hotbeds of contagious (Rivera-Izquierdo et al, 2020). Nonetheless they need to be increased and enlarged on the territory according to infection spread.…”