Socio-economic factors and immigrant population studies of multiple sclerosis

Berg‐Hansen, Pål; Celius, E. G.

doi:10.1111/ane.12429

Cited by 26 publications

(21 citation statements)

References 46 publications

(51 reference statements)

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“…Based on migration studies, key environmental exposures associated with adult MS onset occur before age 15. New evidence suggests that risk exposures may occur in utero and in neonates .…”

Section: Cause Versus Course – Are the Risk Factors Different?mentioning

confidence: 99%

Environmental and genetic risk factors for MS: an integrated review

Waubant

Lucas

Mowry

et al. 2019

Ann Clin Transl Neurol

219

184

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Recent findings have provided a molecular basis for the combined contributions of multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a chronic dysregulation of immune homeostasis resulting from complex interactions between genetic predispositions, infectious exposures, and factors that lead to pro‐inflammatory states, including smoking, obesity, and low sun exposure. This is supported by the discovery of gene–environment (GxE) interactions and epigenetic alterations triggered by environmental exposures in individuals with particular genetic make‐ups. It is notable that several of these pro‐inflammatory factors have not emerged as strong prognostic indicators. Biological processes at play during the relapsing phase of the disease may result from initial inflammatory‐mediated injury, while risk factors for the later phase of MS, which is weighted toward neurodegeneration, are not yet well defined. This integrated review of current evidence guides recommendations for clinical practice and highlights research gaps.

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“…Based on migration studies, key environmental exposures associated with adult MS onset occur before age 15. New evidence suggests that risk exposures may occur in utero and in neonates .…”

Section: Cause Versus Course – Are the Risk Factors Different?mentioning

confidence: 99%

Environmental and genetic risk factors for MS: an integrated review

Waubant

Lucas

Mowry

et al. 2019

Ann Clin Transl Neurol

219

184

View full text Add to dashboard Cite

show abstract

“…1,5 Although the etiology of MS remains unknown, genetic predisposition and environmental factors jointly trigger the disease. 2,6 The prevalence of MS varies geographically, and high-prevalence areas include Canada, the northern United States, most of northern Europe, New Zealand, southeastern Australia and Israel. 7 The prevalence of MS in Canada is among the highest worldwide.…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts

Amankwah

Marrie

Bancej

et al. 2017

Health Promot Chronic Dis Prev Can

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“…12,13 The study of interaction(s) between these factors has been limited by the relative rarity of MS, relatively common exposures, and the time lag between exposure and MS development. It is possible that changes in environmental exposures are responsible for the increase in MS incidence in immigrants to high risk areas, 14,15 but this remains unknown.…”

mentioning

confidence: 99%

Ethnic and Socioeconomic Associations with Multiple Sclerosis Risk

Dobson

Jitlal

Marshall

et al. 2020

Annals of Neurology

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Objective Epidemiological research in multiple sclerosis (MS) has mainly been performed in socioeconomically and ethnically limited populations; influences on MS risk have not been studied in prospectively collected non‐White populations. We set out to study the influence of previously described MS risk factors in an ethnically diverse population. Methods A nested case–control study was created using primary care records of >1 million individuals, >50% of whom identify as Black, Asian, and Minority Ethnic (BAME). MS cases were compared to an age‐ and sex‐matched control cohort (1:4), and to a large unmatched cohort. Odds ratios (ORs) of disease were determined according to exposure of interest, and a multivariate model including all exposures was created. Potential pairwise interactions were considered where both indicated a significant effect. Results A total of 1,344 confirmed MS cases were included. MS OR in blacks aged <40 years was 1.15 (95% confidence interval [CI] = 0.81–1.62) compared to whites. MS odds in BAME current (OR = 1.71, 95% CI = 1.24–2.31) and ex‐smokers (OR = 2.83, 95% CI = 2.14–3.72) were considerably higher than in Whites (OR = 1.09, 95% CI = 0.88–1.34; OR = 1.44, 95% CI = 1.19–1.74, respectively). Prior infectious mononucleosis was associated with increased odds of MS in Blacks (OR = 4.94, 95% CI = 1.23–17.89). An increase in MS odds was seen in the least‐deprived quintile (OR = 2.46, 95% CI = 1.40–4.24), but no effect across deprived quintiles was seen. Interpretation This cohort provides novel data on factors potentially driving MS susceptibility in a diverse population, one‐third of whom live in poverty. Environmental exposures have differential risk across ethnicity. ANN NEUROL 2020;87:599–608

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Socio-economic factors and immigrant population studies of multiple sclerosis

Abstract: Celius EG. Socio-economic factors and immigrant population studies of multiple sclerosis.

Cited by 26 publications

References 46 publications

Environmental and genetic risk factors for MS: an integrated review

Environmental and genetic risk factors for MS: an integrated review

Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts

Ethnic and Socioeconomic Associations with Multiple Sclerosis Risk

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