Socio-Demographic Profile, Asymptomatic Malaria Parasitaemia and Glycemic Control among Midled-Aged and Elderly Type 2 Diabetes Mellitus Patients in Rural Southwestern Nigeria: A Cross Sectional Study

Ibrahim, Azeez Oyemomi; Ajani, Gbadebo Oladimeji; Adewoye, kayode Rasaq; Olanrewaju, Temitope Moronkeji; Afolabi-Obe, Eniola Ayoyemi; Ibikunle, Austine Idowu

doi:10.54931/2053-4787.30-3-1

Cited by 2 publications

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“…Furthermore, the finding in the current study was also in agreement with another cross-sectional study conducted in rural Southwestern Nigeria where it was reported that individuals with type 2 diabetes mellitus were associated with the presence of asymptomatic P . falciparum [ 31 ]. The findings in the current study and these other studies suggest that adult-type diabetic individuals were potential reservoirs of asymptomatic infections.…”

Section: Discussionmentioning

confidence: 99%

“…However, a recent study from central Africa has attributed the association to anti-parasitic immunity, which prevents parasitaemia from reaching a clinical level called pyrogenic threshold and for preventing secondary infection in adults with primary asymptomatic infections [ 32 ]. Other studies have linked the association between asymptomatic infections and individuals with T2DM to increased mosquito bites, and olfactory signals mediate mosquito attraction [ 14 , 31 , 33 ]. The current finding calls for the investigation of high-risk individuals aged 40 years and above for asymptomatic carriage of malaria parasites as an intervention for ensuring malaria elimination.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido-Ekiti, Southwestern Nigeria

et al. 2023

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Background Asymptomatic malaria infections have received less attention than symptomatic malaria infections in major studies. Few epidemiological studies on asymptomatic malaria infections have often focused on pregnant women and children under-five years of age as the most vulnerable groups. However, there is limitation on data regarding asymptomatic infections among the old adult populations, particularly in the study area. Therefore, this study determined the prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido- Ekiti, Southwestern Nigeria. Methods A hospital-based cross-sectional study was conducted between July and September 2021 among 232 consenting apparently healthy individuals aged 40 years and above who were recruited during a free health screening program using a standardised interviewer-administered questionnaire. The questionnaire sought information on respondents’ socio-demographics, presence and types of co-morbidity, and the prevention methods being adopted against malaria infection. Venous blood samples were collected and processed for asymptomatic infections using Giemsa-stained blood smear microscopy. Data were analysed using SPSS version 21. Multivariate logistic regression was used to identify factors associated with asymptomatic infections. Results Of the total 232 respondents, 19.0% (48/232) were confirmed to be infected with Plasmodium falciparum (95% confidence interval (CI): 14.1% - 24.6%). Lack of formal education (Adjusted odds ratio (AOR): 5.298, 95% (CI): 2.184-13.997), being diabetic (AOR: 4.681, 95% CI: 1.669-16.105), and not sleeping under Long Lasting Insecticide Net (LLINs) (AOR: 4.594, 95% CI: 1.194-14.091), were the determinants of asymptomatic Plasmodium falciparum infection. Conclusion The prevalence of asymptomatic Plasmodium falciparum was 19%. Lack of formal education, being diabetic, and not sleeping under LLINs were the determinants of asymptomatic infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido-Ekiti, Southwestern Nigeria

et al. 2023

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“…The strategy stated that artemisinin -based combination (ACTs) therapy such as artemetherlumefantrine (A-L) remains the first-line of treatment for uncomplicated malaria because it is highly effective. Several studies reported symptomatic and asymptomatic cases of malariainfected individuals with diabetes under antimalarial medication in Nigeria [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Study of Glucometer Precision and Antimalarial Therapy Interference on Glucose Readings in Nigeria

Ugochukwu,

Mosanaya,

Nweze

et al. 2023

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Malaria-infected diabetic (MID) patients have become one of the highest diabetic population with comorbidities in Nigeria. While the artemisinin-based combination therapy (ACT) are used for malaria treatment, glucometers are used to monitor their blood glucose levels. However, some drugs are known to interfere with the accuracy of glucose readings leading to misdiagnosis. In this study, we investigated the interferences of artemether and lumefantrine as well as other known drug interferents on the accuracy of glucose readings in three different glucometers commonly used in Nigeria (Accu-Answer, VivaChek and GlucoDr). Blood sample was collected from a healthy volunteer, aliquots of the blood with pure samples of artemether and lumefantrine powders as well as other known drug interferents were prepared in normal and low pools. The precision study on the glucometers were determined. We find that Accu- Answer was the only precise glucometer considering its coefficient of variation. The influence of the artemether and lumefantrine was mild in two glucometers and the predicted binding affinities showed possible binding interactions that may have caused their interferences.

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Socio-Demographic Profile, Asymptomatic Malaria Parasitaemia and Glycemic Control among Midled-Aged and Elderly Type 2 Diabetes Mellitus Patients in Rural Southwestern Nigeria: A Cross Sectional Study

Cited by 2 publications

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Prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido-Ekiti, Southwestern Nigeria

Prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido-Ekiti, Southwestern Nigeria

Study of Glucometer Precision and Antimalarial Therapy Interference on Glucose Readings in Nigeria

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