Societal impact of bilirubin-induced hearing impairment in resource-limited nations

Olusanya, Bolajoko O.

doi:10.1016/j.siny.2014.12.009

Cited by 10 publications

(9 citation statements)

References 68 publications

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“…Bilirubin-induced neurological dysfunction (BIND), a severe complication of neonatal hyperbilirubinemia, still occurs worldwide and leads to a high rate of mortality or lifelong neurological impairments [ 1 , 2 , 32 , 33 ]. For years, research efforts have been made to understand how UCB induces neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes

Feng

Qian

et al. 2018

J Neuroinflammation

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BackgroundBilirubin-induced neurological dysfunction (BIND), a severe complication of extreme neonatal hyperbilirubinemia, could develop into permanent neurodevelopmental impairments. Several studies have demonstrated that inflammation and nerve cell death play important roles in bilirubin-induced neurotoxicity; however, the underlying mechanism remains unidentified.MethodsThe present study was intended to investigate whether pyroptosis, a highly inflammatory form of programmed cell death, participated in the bilirubin-mediated toxicity on cultured rat cortical astrocytes. Further, VX-765, a potent and selective competitive drug, was used to inhibit the activation of caspase-1. The effects of VX-765 on astrocytes treated with bilirubin, including the cell viability, morphological changes of the cell membrane and nucleus, and the production of pro-inflammation cytokines, were observed.ResultsStimulation of the astrocytes with unconjugated bilirubin (UCB) at the conditions mimicking those of jaundiced newborns significantly increased the activation of caspase-1. Further, caspase-1 activation was inhibited by treatment with VX-765. Compared with UCB-treated astrocytes, the relative cell viability of VX-765-pretreated astrocytes was improved; meanwhile, the formation of plasma membrane pores was prevented, as measured by lactate dehydrogenase release, trypan blue staining, and ethidium bromide (EtBr) uptake. Moreover, DNA fragmentation was partly attenuated and the release of IL-1β and IL-18 was apparently decreased.ConclusionPyroptosis is involved in the process of UCB-induced rat cortical astrocytes’ injury in vitro and may be the missing link of cell death and inflammatory response exacerbating UCB-related neurotoxicity. More importantly, the depression of caspase-1 activation, the core link of pyroptosis, attenuated UCB-induced cellular dysfunction and cytokine release, which might shed light on a new therapeutic approach to BIND.

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Section: Discussionmentioning

confidence: 99%

Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes

Feng

Qian

et al. 2018

J Neuroinflammation

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“…[6][7][8][9] In fact, untreated sensorineural hearing impairment in the first year of life has profound adverse consequences that transverse almost all developmental domains, manifesting in significant and often lifelong deficits in gross and fine motor skills, cognitive performance, speech and language development, and psychosocial development ( Figure 1). 10 Although the rates of emotional, intellectual, physical, and social development vary within each child and from child to child, a child with hearing impairment is faced with greater challenges than his/her normal hearing peers. The overall socioeconomic impact is substantial for the affected child, the family, and the community.…”

Section: Introductionmentioning

confidence: 99%

“…The overall socioeconomic impact is substantial for the affected child, the family, and the community. [10][11][12] For example, studies from high-income countries estimate the lifetime educational cost…”

Section: Introductionmentioning

confidence: 99%

Screening for neonatal deafness in resource-poor countries: challenges and solutions

Olusanya¹

2015

RRN

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Newborn or neonatal hearing screening (NHS) is offered routinely in high-income countries as an essential and mandatory intervention for the early detection of infants with permanent congenital or early-onset hearing loss. However, NHS is rarely offered presently in the vast majority of low-and middle-income countries, which account for over 80% of the incidence and burden of permanent congenital or early-onset hearing loss worldwide. This review provides an overview of the current status of NHS programs in the most developmentally disadvantaged low-and middle-income countries with a per capita income of approximately US$6,000 or less against the backdrop of relevant recommendations for effective NHS programs. It highlights the key obstacles to the delivery and uptake of NHS services based on a review of available literature from the eligible countries. It proposes strategies for addressing these challenges and examines the crucial role of pediatricians and primary care physicians in providing leadership for the requisite multidisciplinary efforts to develop and promote effective NHS services in low-and middle-income countries.

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“…Numerous studies evaluating the relevance of excessive bilirubin con centrations for impairment of nervous system func tions in newborns (especially, in the event of preterm delivery) keep drawing attention of many clinicians worldwide [46][47][48][49]. There are some reports on the relevance of hyperbilirubinemia in the postnatal period for hearing impairment in countries with insufficient economic resources [50]. These findings confirm the toxic effect of high bilirubin concentrations, at least, on the most sen sitive sphere: immature nervous system of new borns.…”

Section: Sorbents For Removal Of Bilirubinmentioning

confidence: 99%

“…Многочисленные исследования, посвященные значению избыточных концентра ций билирубина для нарушения функционирова ния нервной системы у новорожденных (в особен ности -при преждевременном родоразрешении), сегодня снова привлекают внимание многих кли ницистов в мире [46][47][48][49]. Появляются отдельные сообщения и о значении гипербилирубинемии в постнатальном периоде при развитии расстройств слуха в странах с недостаточностью экономичес ких ресурсов [50]. Все это свидетельствует в поль зу токсического действия высоких концентраций билирубина, по крайней мере, на наиболее чувст вительную сферу -незрелую нервную систему но ворожденных.…”

Section: Sorbents For Removal Of Bilirubinunclassified