Background: In 2018 there were approximately 228 million diagnosed cases of malaria and 405,000 deaths. The use of insecticide-treated nets (ITNs) is one of the main malaria prevention interventions. Despite widescale distribution resulting in improved ITN access, use remains an important challenge. This study determined factors associated with the use of ITNs among women of reproductive age in Mozambique in 2018.Methods: A secondary analysis of data from the 2018 Malaria Indicator Survey (MIS) was implemented. Women of reproductive age (15-49 years) from households with at least one ITN were included in the analysis. Appropriately weighted descriptive analysis of sociodemographic characteristics and univariate and multivariate logistic regression were performed to identify factors associated with ITN use. The highest frequency categories were used as reference variables for the variables age, province, type of place of residence and wealth quintile and the lowest frequency category was used for education level. Variables that had p-value <0.05 were considered statistically significant.Results: Of 6,184 total women of reproductive age in the MIS, 5,587 women (90%) were in households with at least one ITN, of whom 88% (4,908/5,587) reported prior night use of ITNs. Most women were in the 15-19 age group of whom 81% (975/1,206) reported ITN use. The odds of ITN use were significantly higher in all other age groups compared to these women aged 15-19 years. The odds of ITN use were significantly lower in lower prevalence provinces in southern Mozambique. In adjusted analysis, there was no significant association between the odds of ITN use and malaria knowledge, exposure to malaria messages, literacy, or other sociodemographic variables.Conclusions:. Young women and those in southern Mozambique are demographic groups that would benefit from targeted communication interventions, along with those in rural areas where the burden of malaria is higher.