Social transfer of pain in mice

Smith, Monique L.; Hostetler, Caroline M.; Heinricher, Mary M.; Ryabinin, Andrey E.

doi:10.1126/sciadv.1600855

Cited by 117 publications

(141 citation statements)

References 62 publications

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“…This is an important distinction, as cessation of alcohol intake following repeated drug exposure can exacerbate pain sensitivity. This phenomenon, commonly referred to as EtOH withdrawal-induced hyperalgesia (EIH), has been reported in mice (Dhir et al, 2005; Smith et al, 2016), as well as rats (Dina et al, 2000, 2007; Edwards et al, 2012; Fu et al, 2015; Gatch and Lal, 1999; Malec et al, 1987; Roltsch et al, 2017; Shumilla et al, 2005) and humans (Boissoneault et al, 2018; Dodds et al, 1945; Jochum et al, 2010; Riley and King, 2009; Wolff et al, 1942), using a variety of alcohol exposure models. In our CA2BC paradigm, it is unclear whether there were pathological shifts in sensitivity following three weeks of alcohol exposure.…”

Section: Discussionmentioning

confidence: 99%

Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice

Hwa

Makhijani

et al. 2019

Alcohol

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Sex differences in chronic pain and alcohol abuse are not well understood. The development of rodent models is imperative for investigating the underlying changes behind these pathological states. In the present study, we investigated whether hind paw treatment with the inflammatory agent Complete Freund’s Adjuvant (CFA) could generate hyperalgesia and alter alcohol consumption in male and female C57BL/6J mice. CFA treatment led to greater nociceptive sensitivity for both sexes in the Hargreaves test, and increased alcohol drinking for males in a continuous access two-bottle choice (CA2BC) paradigm. Regardless of treatment, female mice exhibited greater alcohol drinking than males. Following a 2-hour terminal drinking session, CFA treatment failed to produce changes in alcohol drinking, blood ethanol concentration (BEC), and plasma corticosterone (CORT) for both sexes. 2-hr alcohol consumption and CORT was higher in females than males, irrespective of CFA treatment. Taken together, these findings have established that male mice are more susceptible to escalations in alcohol drinking when undergoing pain, despite higher levels of total alcohol drinking and CORT in females. Furthermore, the exposure of CFA-treated C57BL/6J mice to the CA2BC drinking paradigm has proven to be a useful model for studying the relationship between chronic pain and alcohol abuse. Future applications of the CFA/CA2BC model should incorporate manipulations of stress signaling and other related biological systems to improve our mechanistic understanding of pain and alcohol interactions.

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Section: Discussionmentioning

confidence: 99%

Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice

Hwa

Makhijani

et al. 2019

Alcohol

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“…This suggests that ethanol intoxication, but not withdrawal, may increase the short-term consequences of shock. However, work has shown that ethanol withdrawal, not intoxication, can cause increased sensitivity to stressors and tactile sensitivity (Rassnick, Koob, & Geyer, 1992; Smith, Hostetler, Heinricher, & Ryabinin, 2016). …”

Section: Discussionmentioning

confidence: 99%

Rapid reacquisition of contextual fear following extinction in mice: effects of amount of extinction, acute ethanol withdrawal, and ethanol intoxication

Williams

Lattal

2018

Psychopharmacology

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Rationale: Many studies have found that ethanol intoxication and withdrawal impairs initial acquisition or extinction of learned behaviors. Rapid reconditioning following extinction is a form of post-extinction re-emergence of conditioned behavior that has not been studied for its interaction with ethanol intoxication or withdrawal. Objectives: The goals of this paper were to define the parameters that allow rapid post-extinction reacquisition of fear in mice and investigate the effect of acute ethanol withdrawal and intoxication on acquisition, extinction, and post-extinction reconditioning. Methods: We examined acquisition, extinction, and post-extinction reconditioning of contextual fear in male C57BL/6 mice. Acute ethanol withdrawal occurred 6 hr following a 4 g/kg injection of 20% ethanol and acute ethanol intoxication occurred 5 min following a 1.5 g/kg injection of 20% ethanol. Results: A weak context-shock pairing caused rapid reacquisition of conditioned freezing following moderate, but not extensive extinction. Acute ethanol intoxication impaired initial conditioning and acute ethanol withdrawal impaired rapid reacquisition after extinction, but not reconditioning or extinction itself. Conclusions: These findings show that rapid reconditioning occurs following moderate, but not extensive extinction in C57BL/6J mice. Additionally, acute ethanol withdrawal and intoxication may differentially affect different phases of conditioning. Results are discussed in terms of current ideas about post-extinction behavior and ethanol’s effects on memory.

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“…In most cases, animals are tested in groups, and social factors can alter results as well. We and others have found that pain sensitivity can be increased (by emotional contagion [110][111][112][113] or social SIH 88,111 ), or decreased (by social SIA 88,110 or social buffering [114][115][116][117][118] ) when animals are in close proximity (through either visual 110 or olfactory 113,119 mechanisms), depending on their social status (siblings, familiars, or strangers) and the threat level determined by their degree of physical access to each other. Our laboratory surprisingly observed that the mere presence of a male (but not female) experimenter in the testing room could produce stress in mice and rats, producing olfactory-mediated SIA that robustly affected apparent "baseline" pain sensitivity 119 .…”

Section: Jeffrey S Mogilmentioning

confidence: 92%

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

Mogil

2017

Lab Anim

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Social transfer of pain in mice

Abstract: Bystander mice living in the same room as mice with inflammatory- or withdrawal-induced hyperalgesia develop an abnormal pain state.

Cited by 117 publications

References 62 publications

Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice

Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice

Rapid reacquisition of contextual fear following extinction in mice: effects of amount of extinction, acute ethanol withdrawal, and ethanol intoxication

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

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