Social suppression of cortisol in female marmosets: Role of luteinizing hormone/chorionic gonadotropin

Saltzman, Wendy; Hogan, Brynn K.; Horman, Brian; Abbott, David H.

doi:10.1016/j.ygcen.2006.05.007

Cited by 13 publications

(9 citation statements)

References 39 publications

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“…Replacement of E2 to ovariectomized female rhesus monkeys also decreased morning cortisol levels, consistent with other data indicating E2 decreases basal or stress-induced activation of the LHPA axis (Patchev and Almeida, 1996; Saltzman et al, 2006; Young et al, 2001). However, other studies show that E2 increases activation of the LHPA axis (Viau and Meaney, 1991) by decreasing glucocorticoid negative feedback (Patchev and Almeida, 1996; Wilson et al, 2005); increasing adrenal sensitivity to ACTH (Figueiredo et al, 2007) and enhancing diurnal (Gudmundsson et al, 1999; Smith and Norman, 1987) or morning cortisol secretion (Giussani et al, 2000; Stavisky et al, 2003).…”

Section: Discussionsupporting

confidence: 90%

Estradiol effects on behavior and serum oxytocin are modified by social status and polymorphisms in the serotonin transporter gene in female rhesus monkeys

Michopoulos

Checchi

Sharpe

et al. 2011

Hormones and Behavior

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Despite the well-documented relation between estradiol (E2) and behavior, exposure to stressors may modify sensitivity to E2. The effects of E2 on behavior are, in part, likely related to their modulation of the serotonin (5HT) and oxytocin systems. The short allele (s-variant) polymorphism found in the promoter region of the SLC6A4 gene that encodes the 5HT transporter (5HTT) modulates responsivity to stressors. The current study used ovariectomized adult female rhesus monkeys to evaluate how exposure to the psychosocial stressor of social subordination and polymorphisms in the gene encoding 5HTT influence the behavioral effects of E2 and immunoreactive serum oxytocin. Dominant females had higher levels of oxytocin than subordinate animals even though E2 increased immunoreactive serum oxytocin in all females. E2 increased affiliative behaviors in all animals, with even more of these prosocial behaviors directed at dominant females. S-variant females, regardless of social status, were more aggressive towards more subordinate cage mates and these behaviors too were increased by E2. Subordinate s-variant females are most often involved in agonistic behavior, less affiliative behavior, and were less responsive to the anxiolytic action of E2. The results show that the short allele of the 5HTT gene synergizes with psychosocial stress exposure to affect the behavioral efficacy of E2 while confirming the actions of E2 for producing generalized behavioral arousal in females. Whether differences in the central action of 5HT and/or oxytocin are responsible for this effect requires further study.

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Section: Discussionsupporting

confidence: 90%

Estradiol effects on behavior and serum oxytocin are modified by social status and polymorphisms in the serotonin transporter gene in female rhesus monkeys

Michopoulos

Checchi

Sharpe

et al. 2011

Hormones and Behavior

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“…Estradiol increases activation of the LHPA axis [90] by decreasing glucocorticoidnegative feedback [91][92][93], increasing adrenal sensitivity to ACTH [94] as well as hypothalamic CRH content [95][96][97], and enhancing diurnal [98,99] or morning cortisol secretion [100,101]. In contrast, other studies show that E2 decreases basal or stress-induced activation of the LHPA axis [91,[102][103][104][105]. The aim of this study was not to understand how E2 regulates cortisol secretion and LHPA activity, because the design was chosen to balance both E2 and the CRH receptor analogue treatments.…”

Section: Group and Treatment Differences In Serum Cortisolmentioning

confidence: 97%

Social Subordination and Polymorphisms in the Gene Encoding the Serotonin Transporter Enhance Estradiol Inhibition of Luteinizing Hormone Secretion in Female Rhesus Monkeys1

Michopoulos¹,

Berga²,

Kaplan³

et al. 2009

Biology of Reproduction

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Psychosocial factors, particularly social stress, may compromise reproduction. However, some individuals may be more susceptible to socially induced infertility. The present study used group-housed, adult, ovariectomized rhesus monkeys to test the hypothesis that exposure to psychosocial stress, imposed by social subordination, would enhance estradiol (E2)-negative feedback inhibition of LH. Because polymorphisms in the gene encoding the serotonin transporter (SLC6A4) may contribute to individual differences in response to adverse environments, we determined whether subordinate females with the short-promoter-length allele (s-variant) would show greater suppression of LH. Subordinate females, particularly those with the s-variant SLC6A4 genotype, received significantly higher rates of noncontact aggression from more dominant cage mates and had consistently lower body weights. Serum LH was not influenced by social status in the absence of E2. In contrast, subordinate females were hypersensitive to E2-negative feedback inhibition of LH. Furthermore, serum LH in subordinate females with s-variant SLC6A4 genotype was maximally suppressed by Day 4 of treatment, whereas nadir concentrations were not reached until later in treatment in other females. Finally, pharmacological elevation of serum cortisol potentiated E2-negative feedback inhibition in all females. The current data suggest that infertility induced by psychosocial stressors may be mediated by hypersensitivity to E2-negative feedback and that polymorphisms in the SLC6A4 gene may contribute to differences in reproductive compromise in response to chronic stress.

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“…As our findings control for variation in the capture-to-sampling time lag and allow for the possibility that the shape of the stress response to capture differed across the two periods, the documented increase in urinary cortisol concentrations most likely reflects an increase in baseline plasma cortisol concentrations during the wet period, which could have one of several causes. The increase could simply reflect the energetic demands associated with the wet period surges in tunneling or the stimulatory effect that increases in circulating LH levels, and/or consequent increases in estrogen levels, can have on the hypothalamic-pituitary-adrenal axis (see Saltzman et al 2006a;2006b and discussion therein). More intriguing, however, is the possibility that this contrast could also reflect an increase in social stress induced by the dominant female, who may be selected to respond aggressively either to physiological up-regulation among subordinate females or to environmental conditions conducive to forcing their dispersal Stephens et al 2005).…”

Section: Dispersal Patternsmentioning

confidence: 99%

Physiological suppression eases in Damaraland mole-rat societies when ecological constraints on dispersal are relaxed

Young

Oosthuizen

Lutermann

et al. 2010

Hormones and Behavior

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In many vertebrate societies, subordinate females exhibit down-regulated reproductive physiologies relative to those of dominants, a condition commonly termed physiological suppression. Research into the causes of physiological suppression has focused principally on the role of the subordinate's social environment (typically the presence of the dominant female and/or an absence of unrelated males within the group), while few studies have considered the additional role that the physical environment may play. Here we present new evidence from wild Damaraland mole-rats, Fukomys damarensis, revealing that physiological suppression among subordinate females eases markedly during the annual rains (a time when ecological constraints on dispersal are relaxed), despite the continued presence of the dominant female and in groups that contain no new immigrant males. Subordinate females showed substantially higher pituitary sensitivities to GnRH challenge during the wet period than the dry, a contrast that cannot be attributed to between-female differences (as it holds for paired within-female comparisons), associated changes in body mass (as our analyses control for this), or concomitant reductions in physiological stress (as their urinary cortisol concentrations were actually higher in the wet period). We suggest that our findings reflect selection for the maintenance of reproductive readiness among subordinate females during high rainfall periods, given the increased likelihood of encountering dispersal and/or mating opportunities with extra-group males when ecological constraints on dispersal are relaxed.These findings reveal new complexity in the processes that regulate physiological suppression, suggesting a key role in some species for changes in the physical as well as social environment.

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Social suppression of cortisol in female marmosets: Role of luteinizing hormone/chorionic gonadotropin

Cited by 13 publications

References 39 publications

Estradiol effects on behavior and serum oxytocin are modified by social status and polymorphisms in the serotonin transporter gene in female rhesus monkeys

Estradiol effects on behavior and serum oxytocin are modified by social status and polymorphisms in the serotonin transporter gene in female rhesus monkeys

Social Subordination and Polymorphisms in the Gene Encoding the Serotonin Transporter Enhance Estradiol Inhibition of Luteinizing Hormone Secretion in Female Rhesus Monkeys1

Physiological suppression eases in Damaraland mole-rat societies when ecological constraints on dispersal are relaxed

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