Social support and unsupportive interactions in relation to depressive symptoms: Implication of gender and the BDNF polymorphism

Woods, Robbie; McInnis, Opal A.; Bedard, Marc; Asokumar, Ajani; Santoni, Samantha; Anisman, Hymie; Matheson, Kimberly; McQuaid, Robyn J.

doi:10.1080/17470919.2019.1650826

Cited by 13 publications

(10 citation statements)

References 57 publications

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“…Research in genetic-social interaction in depression is limited. The study of Woods et al 33 found no moderation effect of one single polymorphisms in BDNF gene in the relation between social support and depression among 945 students. Still gene-environment interactions with candidate genes in depression are criticized as results can rarely be replicated.…”

Section: Discussionmentioning

confidence: 93%

Genetic Liability for Depression, Social Factors and Their Interaction Effect in Depressive Symptoms and Depression Over Time in Older Adults

Stringa

Milaneschi

Schoor

et al. 2020

The American Journal of Geriatric Psychiatry

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Section: Discussionmentioning

confidence: 93%

Genetic Liability for Depression, Social Factors and Their Interaction Effect in Depressive Symptoms and Depression Over Time in Older Adults

Stringa

Milaneschi

Schoor

et al. 2020

The American Journal of Geriatric Psychiatry

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“…For males, participation in social activities of long-standing interest was positively associated with suicide plans or attempts, which was unexpected. However, the nature of these interactions is unknown; for example, the experience of unexpected, unsupportive social interactions is strongly related to poor mental health ( 51 ). It is also possible that males with suicidal ideation try to disguise their worsening mental state by engaging in their usual associations and activities.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Determinants of Suicide Risk Preceding Psychiatric Admission: An Electronic Medical Record Study

et al. 2022

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BackgroundIndividuals requiring inpatient psychiatric care represent a group at higher risk of progressing toward suicide attempt. Using electronic medical record (EMR) data collected from psychiatric inpatient admissions, the objective of this study was to identify sex differences in risk factors for suicide plans and/or attempts within the 30 days preceding hospital admission.MethodsResident Assessment Instrument for Mental Health (RAI-MH) intake data were obtained for patients admitted to a Canadian tertiary-care hospital deemed a “threat or danger to self” during a 10-year period (2008–2018). Data was extracted for individuals categorized into three groups: non-suicidal (N = 568), presence of suicide plan (N = 178), and presence of suspected suicide attempt (N = 124) in the 30 days prior to hospital admission. Multivariate logistic regression models were used to examine determinants of suicide risk.ResultsAcross all models, diagnosis of depression was the strongest predictor of suicide plan and/or attempt (OR = 5.54, 95% CI = 3.71–8.27, p < 0.001). Comparing clinical symptoms between suicidal and non-suicidal groups at the time of admission, the largest effect sizes were found for hopelessness (p < 0.001, η2 = 0.11), and guilt or shame (p < 0.001, η2 = 0.09). Female sex was identified as a significant factor for elevated suicidal risk (OR = 1.56, 95% CI = 1.01–2.21, p = 0.01), thus we stratified the regression model by sex to identify specific risk factors for suicide plan and/or attempt for males and females. Among males, having no confidant (OR = 2.13, 95% CI = 1.19–3.80, p = 0.01), presence of recent stressors (OR = 1.95, 95% CI = 1.16–3.29, p = 0.01), and participation in social activities (OR = 1.67, 95% CI = 1.02–2.71, p = 0.04) were important predictors, while among females, younger age (OR = 0.96, 95% CI = 0.94–0.97, p < 0.001) increased odds of suicide plan and/or attempt.ConclusionEMR-derived findings highlight different psychosocial and clinical determinants for males and females associated with suicide plan or attempt prior to psychiatric admission. Identifying precipitating factors that elevate imminent suicide risk may inform suicide prevention efforts for psychiatric inpatients.

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“…However, these interactions may not have been positive, in-line with data showing that expecting support and instead experiencing unsupportive social interactions is strongly related to poor mental health. 46 It is also possible that males with suicidal ideation made an effort to disguise their worsening mental state by engaging in their usual associations and activities. This is consistent with reports that males are more likely than females to self-stigmatize depression and suicidal thoughts and behaviours.…”

Section: Discussionmentioning

confidence: 99%

Sex-differences in determinants of suicide risk preceding psychiatric admission: An electronic medical record study

McQuaid

Nikolitch

Vandeloo

et al. 2020

Preprint

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Using electronic medical record (EMR) data collected from psychiatric inpatient admissions, the objective of this study was to identify sex differences in risk factors for presence of suicide plans and/or attempts within the 30 days preceding hospital admission. Resident Assessment Instrument for Mental Health (RAI-MH) intake data were obtained for patients admitted to a Canadian tertiary-care hospital deemed a ‘threat or danger to self’ during a ten-year period (2008-2018). Data was extracted for individuals categorized into three groups: non-suicidal (N=568), presence of suicide plan (N=178), and presence of suspected suicide attempt (N=124) in the 30 days prior to hospital admission. A multivariate logistic regression revealed that younger age (odds ratio=0.97), female sex (OR=1.56), disrupted family relationships (OR=1.54), recent stressors (OR=1.59), participation in social activities (OR=1.54), having no confidant (OR=1.55), and diagnosis of depressive disorder (OR=5.54) increased the odds of suicide plan and/or attempt in the 30 days prior to hospital admission. Stratifying the regression model by sex highlighted different risk factors for suicide plan and attempt specific to males and females. EMR-derived findings highlight psychosocial and clinical determinants associated with suicide plan or attempt prior to psychiatric admission that differ according to sex.

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Social support and unsupportive interactions in relation to depressive symptoms: Implication of gender and the BDNF polymorphism

Cited by 13 publications

References 57 publications

Genetic Liability for Depression, Social Factors and Their Interaction Effect in Depressive Symptoms and Depression Over Time in Older Adults

Genetic Liability for Depression, Social Factors and Their Interaction Effect in Depressive Symptoms and Depression Over Time in Older Adults

Sex Differences in Determinants of Suicide Risk Preceding Psychiatric Admission: An Electronic Medical Record Study

Sex-differences in determinants of suicide risk preceding psychiatric admission: An electronic medical record study

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