Social stress by repeated defeat: effects on social behaviour and emotionality

Albonetti, Maria Emanuela; Farabollini, Francesca

doi:10.1016/0166-4328(94)90027-2

Cited by 78 publications

(47 citation statements)

References 60 publications

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“…Our findings extend earlier observations in rodents exposed to social defeat stress and demonstrate that repeated confrontation with an aggressive dominant conspecific animal produced a marked loss of body weight [31]. These changes in body weight are in line with earlier findings showing a subsequent suppression of growth rate and even weight loss, which was unlikely to have been attributed to a reduction of food intake after several days after the social conflict [32].…”

Section: Discussionsupporting

confidence: 92%

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Ahnaou

Drinkenburg²

2016

Neuropsychobiology

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Depression is a heterogeneous disorder characterized by alterations at psychological, behavioural, physiological, neurophysiological, and neurochemical levels. Social stress is a prevalent stress in man, and the repeated social defeat stress model in rats has been proposed as being the rodent equivalent to loss of control, which in subordinate animals produces alterations that resemble several of the cardinal symptoms found in depressed patients. Here, rats followed a resident-intruder protocol for 4 consecutive days during which behavioural, physiological, and electroencephalographic (EEG) parameters were simultaneously monitored in subordinate rats. On day 5, prefrontal dopamine (DA) and hippocampal serotonin (5-HT) as well as corticosterone were measured in submissive rats that had visual, acoustic, and olfactory (but no physical) contact with a dominant, resident conspecific rat. Socially defeated rats demonstrated increases in ultrasonic vocalizations (20-25 KHz), freezing, submissive defensive behaviour, inactivity, and haemodynamic response, while decreases were found in repetitive grooming behaviour and body weight. Additionally, alterations in the sleep-wake architecture were associated with reduced active waking, enhanced light sleep, and increased frequency of transitions from light sleep to quiet wakefulness, indicating sleep instability. Moreover, the attenuation of EEG power over the frequency range of 4.2-30 Hz, associated with a sharp transient increase in delta oscillations, appeared to reflect increased brain activity and metabolism in subordinate animals. These EEG changes were synchronous with a marked increase in body temperature and a decrease in locomotor activity. Furthermore, psychosocial stress consistently increased 5-HT, DA, and corticosterone levels.The increased levels of cortical DA and hippocampal 5-HT during social threat may reflect a coping mechanism to promote alertness and psychological adaptation to provocative and threatening stimuli. These neurophysiological changes are hypothesized to be the consequence of dynamics in monoamine systems, which could be useful markers for disease progression in the aetiology of depression.

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Section: Discussionsupporting

confidence: 92%

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Ahnaou

Drinkenburg²

2016

Neuropsychobiology

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“…With respect to the type of stressful social experience, a distinction can be made between those models in which the intruder is exposed only to "physical attack" and those in which it is exposed to both "physical attack" and the "threat of attack." Models that involve only physical attack may be differentiated in terms of (a) the length of confrontation [Haemisch and Gärtner, 1996], (b) the number of bites [Matsuda et al, 1996;Miller et al, 1987], (c) the amount of submissive behavior shown by the intruder [Albonetti and Farabollini, 1994], or (d) the duration of roll-tumble fights [Benjamin et al, 1993]. When both "physical attack" and "threat of attack" are involved, some models identify three phases (pre-attack, attack, and post-attack) [Tornatzky and Miczek, 1994], whereas others identify only two (pre-attack/attack and attack/post-attack) Martinez et al, 1998].…”

Section: Resident/intruder Paradigmmentioning

confidence: 99%

Social defeat and subordination as models of social stress in laboratory rodents: A review

1998

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“…Their aim is to determine the level of the domination and social status of each specimen in the group. Tests made for the purpose of the experiment described in this article were carried out on the basis of the Albonetti and Farabollini method [2]. This method discerns four types of behaviour: aggressive, defensive, ambivalent and neutral.…”

Section: Social Interaction Testsmentioning

confidence: 99%

Comparison of Tracking Methods in Respect of Automation of an Animal Behavioral Test

Mazur-Milecka¹,

Nowakowski²

2011

Metrology and Measurement Systems

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Automation in experiments carried out on animals is getting more and more important in research. Computers take over laborious and time-consuming activities like recording and analysing images of the experiment scene. The first step in an image analysis is finding and distinguishing between the observed animals and then tracking all objects during the experiment. In this paper four tracking methods are presented. Quantitative and qualitative figures of merit are applied to confront those methods. The comparison takes into consideration the level of correct object recognition during different disturbances, the speed of computation, requirements as to the frame rate and image illumination, quality of recovering from occluded situations and others.

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Social stress by repeated defeat: effects on social behaviour and emotionality

Cited by 78 publications

References 60 publications

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress

Social defeat and subordination as models of social stress in laboratory rodents: A review

Comparison of Tracking Methods in Respect of Automation of an Animal Behavioral Test

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