Social stress as a trigger for depressive-like behavior and persistent hyperalgesia in mice: study of the comorbidity between depression and chronic pain

Piardi, LN; Pagliusi, Marco; Bonet, Ijm; Brandão, A.R.; Magalhães, SF; Zanelatto, F.B.; Tambeli, CH; Sartori, CR

doi:10.1016/j.jad.2020.05.144

Cited by 21 publications

(13 citation statements)

References 37 publications

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“…These findings indicate that SDS models could be more relevant for the psychological stress conditions in human life compared with CRS and FS models. Further, SDS increases nociceptive responses in inflammatory- [ 198 , 199 ], lumbar disk herniation- [ 200 ], postsurgical- [ 201 ], visceral- [ 202 ] pain and migraine models [ 203 ]. Recently we demonstrate that SDS conditionings for 10 days are sufficient to increase the masseter muscle nociception [ 204 ], indicating increases in the deep craniofacial nociception under psychosocial stress conditions.…”

Section: Preclinical Models For Psychological Stress and Deep Craniofacial Pain ( Table 1 )mentioning

confidence: 99%

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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Section: Preclinical Models For Psychological Stress and Deep Craniofacial Pain ( Table 1 )mentioning

confidence: 99%

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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“…As the stage progresses, the complication rate of depression increases [ 28 ]. Depression sometimes causes hyperalgesia and can be a major cause of chronic pain [ 29 ]. Pain can also be a cause of depression [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Fluctuating pain in Parkinson's disease: Its prevalence and impact on quality of life

et al. 2021

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Pain is a common non-motor symptom in Parkinson's disease (PD) patients, and the incidence of fluctuating pain may be improved by taking levodopa. There are only a few detailed reports regarding fluctuating pain. In this study, 331 PD patients were classified into three groups: no-pain group (67.4%), non-fluctuating pain group (22.1%), and fluctuating pain group (10.6%). We evaluated patients' background and its impact on the quality of life (QOL) of each group. The pain group exhibited higher levels of depression ( p < 0.0001), had a higher frequency of visual hallucinations ( p = 0.007), and lower QOL (p < 0.0001) compared with the no-pain group. The fluctuating pain group had a younger onset ( p = 0.006), higher Hoehn & Yahr stage ( p = 0.018), and higher frequency of wearing-off ( p < 0.001) and dyskinesia ( p = 0.007) than the other groups. We compared the Parkinson's Disease Questionnaire-8 summary index (PDQ-8 SI) in each pain group to the no-pain group using analysis of variance. As a result, PDQ-8 SI was significantly higher in both the non-fluctuating and fluctuating pain groups ( p < 0.0001). Pain is regarded as a non-negligible symptom that affects the QOL of PD patients, and given the unique characteristics, fluctuating pain might be considered as an independent clinical subtype of PD.

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“…It is possible that pain changes calf motivation for social contact. For instance, a recent study in mice showed that chronic pain increased social avoidance after repeated social defeat [41]. If pain increased social avoidance in calves this may have led to a reduction in feeding at busy times.…”

Section: Plos Onementioning

confidence: 99%

Pessimistic dairy calves are more vulnerable to pain-induced anhedonia

et al. 2020

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Pain induces deficits in appreciation of rewards (i.e. anhedonia) and variation in response to pain may be partly explained by individual differences in general expectations (i.e. optimism). Dairy calves are routinely subjected to painful procedures such as hot-iron disbudding. We tested if female Holstein calves (n = 17) display signs of anhedonia (as evidenced by reduced consumption of a sweet solution) after hot-iron disbudding (performed under general and local anesthesia), and whether individual differences in optimism explain the variation in this response. Individual variation in optimism was measured using responses to two judgment bias tests (performed when calves were 25 d old), and anhedonia was measured by comparing consumption of a sweet solution before and after hot-iron disbudding. We found that intake of the sweet solution declined (by mean ± SD: 48.4 ± 44.3%) on the day after disbudding, and that more pessimistic calves were more affected. Sweet solution consumption did not return to baseline for the duration of the study (i.e. 5 days). Calves reduced their intake of a sweet solution after hot-iron disbudding, consistent with pain-induced anhedonia, and more pessimistic calves showed stronger evidence of anhedonia, suggesting that they were more affected by the procedure. However, our results cannot rule out the possibility that calf responses were driven by anorexia.

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Social stress as a trigger for depressive-like behavior and persistent hyperalgesia in mice: study of the comorbidity between depression and chronic pain

Cited by 21 publications

References 37 publications

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Fluctuating pain in Parkinson's disease: Its prevalence and impact on quality of life

Pessimistic dairy calves are more vulnerable to pain-induced anhedonia

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