PurposeThe study examines potential differences in socioeconomic status (SES) and emigration patterns between Greek international students (IS) and non-international students (non-IS) and their relationship to the brain drain from Greece.Design/methodology/approachThe study draws on a unique database including all the Greek PhD holders and provides detailed information on their SES and mobility patterns. Furthermore, an individual-level SES index is constructed including both human capital and socioeconomic indicators to estimate the magnitude of the brain drain in terms of the SES that emigrated abroad between 1,985 and 2,018.FindingsFirst, Greek IS have a higher educational, professional and economic status compared to Greek non-IS. Moreover, they exhibit a more international profile, inasmuch as they are more likely to remain abroad after graduation to seek employment. Second, the magnitude of the brain drain in terms of SES emigrated abroad (22.5% of the total) is greater than in terms of individuals who moved abroad (13.4% of the total). Specifically, the SES that outflows with an additional Greek skilled emigrant (that is, an additional IS and non-IS residing abroad) is 1.1 times greater than the SES that remains in Greece with an additional non-IS residing in Greece.Originality/valueThe study contributes to the scientific discussion that relates the SES of IS and highly skilled migrants to brain drain and fills the gap in the relevant literature.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-09-2022-0607.