Social Recognition Task in the Rat

Lemaire, Martine

doi:10.1002/0471141755.ph0530s20

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…The test is based on the assumption that adult rats would investigate unfamiliar conspecifics more than familiar ones, unless their social recognition memory is impaired, in which case they fail to recognize already-encountered individuals. The testing protocol was similar to Lemaire ( 2003 ), using juvenile Wistar rats (23–29 days old) as stimulus animals. Juvenile males are old enough to be recognized by the adult animals as distinct individuals, while usually not taken as territorial rivals and therefore not eliciting aggressive responses.…”

Section: Methodsmentioning

confidence: 99%

The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity

Petrásek

Vojtěchová

Lobellová

et al. 2018

Front. Aging Neurosci.

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The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form of Alzheimer's disease (AD). This model mirrors several neuropathological hallmarks of the disease, including the accumulation of beta-amyloid and the formation of amyloid plaques (in homozygous animals only), neuroinflammation and the gradual deterioration of cognitive functions even prior to plaque formation, although it lacks the tauopathy observed in human victims of AD. The goal of the present study was a thorough characterization of the homozygous model with emphasis on its face validity in several domains of behavior known to be affected in AD patients, including cognitive functions, motor coordination, emotionality, sociability, and circadian activity patterns. On the behavioral level, we found normal locomotor activity in spontaneous exploration, but problems with balance and gait coordination, increased anxiety and severely impaired spatial cognition in 4–7 month old homozygous animals. The profile of social behavior and ultrasonic communication was altered in the McGill rats, without a general social withdrawal. McGill rats also exhibited changes in circadian profile, with a shorter free-running period and increased total activity during the subjective night, without signs of sleep disturbances during the inactive phase. Expression of circadian clock gene Bmal1 was found to be increased in the parietal cortex and cerebellum, while Nr1d1 expression was not changed. The clock-controlled gene Prok2 expression was found to be elevated in the parietal cortex and hippocampus, which might have contributed to the observed changes in circadian phenotype. We conclude that the phenotype in the McGill rat model is not restricted to the cognitive domain, but also includes gait problems, changes in emotionality, social behavior, and circadian profiles. Our findings show that the model should be useful for the development of new therapeutic approaches targeting not only memory decline but also other symptoms decreasing the quality of life of AD patients.

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Section: Methodsmentioning

confidence: 99%

The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity

Petrásek

Vojtěchová

Lobellová

et al. 2018

Front. Aging Neurosci.

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“…Subsequently, the adult is re-exposed to the same animal in different experimental sessions. A decrease in social investigation upon repeated encounters is interpreted as an index for social recognition [4][5][6]. An alternative paradigm is the social discrimination test.…”

Section: Introductionmentioning

confidence: 99%

Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine

et al. 2021

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The ability of recognizing familiar conspecifics is essential for many forms of social interaction including reproduction, establishment of dominance hierarchies, and pair bond formation in monogamous species. Many hormones and neurotransmitters have been suggested to play key roles in social discrimination. Here we demonstrate that disruption or potentiation of histaminergic neurotransmission differentially affects short (STM) and long-term (LTM) social recognition memory. Impairments of LTM, but not STM, were observed in histamine-deprived animals, either chronically (Hdc−/− mice lacking the histamine-synthesizing enzyme histidine decarboxylase) or acutely (mice treated with the HDC irreversible inhibitor α-fluoromethylhistidine). On the contrary, restriction of histamine release induced by stimulation of the H3R agonist (VUF16839) impaired both STM and LTM. H3R agonism-induced amnesic effect was prevented by pre-treatment with donepezil, an acetylcholinesterase inhibitor. The blockade of the H3R with ciproxifan, which in turn augmented histamine release, resulted in a procognitive effect. In keeping with this hypothesis, the procognitive effect of ciproxifan was absent in both Hdc−/− and αFMH-treated mice. Our results suggest that brain histamine is essential for the consolidation of LTM but not STM in the social recognition test. STM impairments observed after H3R stimulation are probably related to their function as heteroreceptors on cholinergic neurons.

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“…Previous work demonstrated that compound 42 significantly improved PCP-induced impairments in rat social recognition, suggesting that the social recognition paradigm is sensitive to the effects of NMDAR PAMs. Therefore, compound 42 was evaluated in aged Wistar rats, which exhibit age-induced impairments in social recognition . Social recognition memory is characterized by a reduced interaction (e.g., sniffing, licking, grooming, closely following) with a familiar juvenile rat during a second interaction as compared to the first interaction.…”

Section: Resultsmentioning

confidence: 99%

Neuroactive Steroid N-Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity

Salituro

Botella

et al. 2019

J. Med. Chem.

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Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(S)-hydroxycholesterol (24(S)-HC), is a positive allosteric modulator (PAM) of NMDA receptors. Using 24(S)-HC as a chemical starting point, we have identified other NASs that have good in vitro potency and efficacy. Herein, we describe the structure activity relationship and pharmacokinetic optimization of this series that ultimately led to SGE-301 (42). We demonstrate that SGE-301 enhances long-term potentiation (LTP) in rat hippocampal slices and, in a dose-dependent manner, improves cognition in a rat social recognition study.

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Social Recognition Task in the Rat

Cited by 9 publications

References 15 publications

The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity

The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity

Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine

Neuroactive Steroid N-Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity

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