Social processing by the primate medial frontal cortex

Putnam, Philip T.; Chang, Steve

doi:10.1016/bs.irn.2020.12.003

Cited by 7 publications

(3 citation statements)

References 137 publications

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“…The ventromedial prefrontal cortex (vmPFC) is mainly responsible for inhibition, response selection, and monitoring ( Jones and Graff-Radford, 2021 ). The different functions of these regions broadly suggest that the MFG plays a fundamental role in internally guided cognition ( Putnam and Chang, 2021 ). It has been previously reported that the IFG is part of a language network and is mainly responsible for declarative long-term memory ( Lunsford-Avery et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Altered anterior cingulate cortex subregional connectivity associated with cognitions for distinguishing the spectrum of pre-clinical Alzheimer’s disease

Yuan

Liang

Xue

et al. 2022

Front. Aging Neurosci.

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BackgroundSubjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are considered part of the early progression continuum of Alzheimer’s disease (AD). The anterior cingulate cortex (ACC), a hub of information processing and regulation in the brain, plays an essential role in AD pathophysiology. In the present study, we aimed to systematically identify changes in the functional connectivity (FC) of ACC subregions in patients with SCD and aMCI and evaluate the association of these changes with cognition.Materials and methodsFunctional connectivity (FC) analysis of ACC sub-regions was performed among 66 patients with SCD, 71 patients with aMCI, and 78 healthy controls (HCs). Correlation analyses were performed to examine the relationship between FC of altered ACC subnetworks and cognition.ResultsCompared to HCs, SCD patients showed increased FC of the bilateral precuneus (PCUN) and caudal ACC, left superior frontal gyrus (SFG) and subgenual ACC, left inferior parietal lobule (IPL) and dorsal ACC, left middle occipital gyrus (MOG) and dorsal ACC, and left middle temporal gyrus (MTG) and subgenual ACC, while aMCI patients showed increased FC of the left inferior frontal gyrus (IFG) and dorsal ACC and left medial frontal gyrus (MFG) and subgenual ACC. Compared to patients with SCD, patients with aMCI showed increased FC of the right MFG and dorsal ACC and left ACC and subgenual ACC, while the left posterior cingulate cortex (PCC) showed decreased FC with the caudal ACC. Moreover, some FC values among the altered ACC subnetworks were significantly correlated with episodic memory and executive function.ConclusionSCD and aMCI, part of the spectrum of pre-clinical AD, share some convergent and divergent altered intrinsic connectivity of ACC subregions. These results may serve as neuroimaging biomarkers of the preclinical phase of AD and provide new insights into the design of preclinical interventions.

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Section: Discussionmentioning

confidence: 99%

Altered anterior cingulate cortex subregional connectivity associated with cognitions for distinguishing the spectrum of pre-clinical Alzheimer’s disease

Yuan

Liang

Xue

et al. 2022

Front. Aging Neurosci.

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“…3). We find that group size correlates with the expansion of anatomical regions of the prefrontal default mode network such as cuneus and precuneus, cingulate, medial prefrontal cortex (mpfc), posterior and anterior cingulate cortex (PCC, ACC) that are known to be related to social behaviour 63,64 as well as areas associated with functional terms such psychosis and Results show that in primates, group size and diurnality are associated (q < 0.001, see Supplementary Data 6a) with a higher range parameter, indicating more widespread spatial correlation of measurements of areal sensory specialisation. In contrast, in rodents, fossoriality is associated with a lower range parameter (q < 0.05, Supplementary Data 6a), indicating more segregated sensory processing areas in a subterranean habitat.…”

Section: Evolutionary Neuroecology Of Group Size and Diurnalitymentioning

confidence: 93%

Evolution of cortical geometry and its link to function, behaviour and ecology

et al. 2023

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Studies in comparative neuroanatomy and of the fossil record demonstrate the influence of socio-ecological niches on the morphology of the cerebral cortex, but have led to oftentimes conflicting theories about its evolution. Here, we study the relationship between the shape of the cerebral cortex and the topography of its function. We establish a joint geometric representation of the cerebral cortices of ninety species of extant Euarchontoglires, including commonly used experimental model organisms. We show that variability in surface geometry relates to species’ ecology and behaviour, independent of overall brain size. Notably, ancestral shape reconstruction of the cortical surface and its change during evolution enables us to trace the evolutionary history of localised cortical expansions, modal segregation of brain function, and their association to behaviour and cognition. We find that individual cortical regions follow different sequences of area increase during evolutionary adaptations to dynamic socio-ecological niches. Anatomical correlates of this sequence of events are still observable in extant species, and relate to their current behaviour and ecology. We decompose the deep evolutionary history of the shape of the human cortical surface into spatially and temporally conscribed components with highly interpretable functional associations, highlighting the importance of considering the evolutionary history of cortical regions when studying their anatomy and function.

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“…In recent neurophysiological studies, including our own, it has been shown that the medial prefrontal cortex (mPFC) has neurons that play a role in social behavior, 7 , 14 , 15 , 16 , 17 monitoring reward outcomes and values, 7 , 17 , 18 , 19 and in representations of self and other. 20 This brain area is also associated with more analytical cognitive functions including decision-making, 21 , 22 conflict monitoring, 23 working memory (WM), 24 , 25 , 26 attention, 27 , 28 and in the selection of response tactics.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous oscillatory encoding of “hot” and “cold” information during social interactions in the monkey medial prefrontal cortex

Di Bello,

Falcone,

Genovesio

2024

iScience

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Social processing by the primate medial frontal cortex

Cited by 7 publications

References 137 publications

Altered anterior cingulate cortex subregional connectivity associated with cognitions for distinguishing the spectrum of pre-clinical Alzheimer’s disease

Altered anterior cingulate cortex subregional connectivity associated with cognitions for distinguishing the spectrum of pre-clinical Alzheimer’s disease

Evolution of cortical geometry and its link to function, behaviour and ecology

Simultaneous oscillatory encoding of “hot” and “cold” information during social interactions in the monkey medial prefrontal cortex

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