Social partnering significantly reduced rapid eye movement sleep fragmentation in fear-conditioned, stress-sensitive Wistar-Kyoto rats

DaSilva, Jamie K.; Husain, E.; Lei, Yao; Mann, Graziella L.; Tejani‐Butt, Shanaz M.; Morrison, Adrian R.

doi:10.1016/j.neuroscience.2011.09.066

Cited by 15 publications

(16 citation statements)

References 126 publications

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“…The positive correlation between the negative affective state (less smiling and more crying behaviors) and GREM of the subsequent AS confirms, in human subjects soon after birth, the recent findings in rodents suggesting that negative emotionality could increase phasic events (such as GREM) during REM sleep (DaSilva, Husain, et al, 2011; DaSilva, Lei, et al, 2011). In a very interesting way, social support may protect rats from increasing GREM (considered by the authors as measure of REM sleep fragmentation) during REM sleep (DaSilva, Husain, et al, 2011).…”

Section: Discussionsupporting

confidence: 80%

Effects of different types of contingent tactile stimulation on crying, smiling, and sleep in newborns: An observational study

Cecchini

Baroni

Vito

et al. 2012

Developmental Psychobiology

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Sleep, the brain and the ability to interact with the environment change a great deal over the first year of life; however, there are no studies on the possible influence of different environmental stimulations on the organization of subsequent sleep-wake cycles in infants. The hypothesis of this study was that greater continuity of contingent tactile stimulation decreases crying behavior, subsequent active sleep (AS) and its fragmentation, and increases smiling behavior and subsequent quiet sleep in newborns. Forty out of the 82 newborns (15- to 30-hr old) of the initial sample satisfied the inclusion criteria and completed the first cycle of sleep during the period between two feedings. The 40 newborns were randomly assigned to four groups after 2' of baseline observation: continuous stimulation (CS, n = 10); discontinuous nonperiodic stimulation (DnPS, n = 10); discontinuous periodic stimulation (DPS, n = 10); absent stimulation (AbS, n = 10). During baseline measurements, there were no significant differences in crying and smiling behaviors between the four groups, while during the subsequent stimulated wake, the CS group compared to the DnPS group showed more smiling (p < .05) and less crying (p < .05), longer poststimulation wake before sleep (p < .01) as well as AS with a lower percentage of grouped-rapid eye movements [grouped REM (GREM); p < .001]. The number of GREM during AS was negatively correlated to the number of smiles (p < .05) and positively to the number of cries (p < .05) of the previous stimulated wake. These findings suggest that, after birth, different continuity levels of contingent tactile stimulations may affect crying and smiling behaviors and the organization of behavioral states. AS could have an important role in processing affective states.

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Section: Discussionsupporting

confidence: 80%

Effects of different types of contingent tactile stimulation on crying, smiling, and sleep in newborns: An observational study

Cecchini

Baroni

Vito

et al. 2012

Developmental Psychobiology

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“…While WKYs were known to display inhibited behavior in social challenges (Paré, 2000; Ferguson and Cada, 2004), our results showing a specific avoidance of novel stimulus rats but not novel objects demonstrate a specific inhibition to social cues. Accordingly, WKY rats were previously shown to be sensitive to social stress such as social isolation (Malkesman et al, 2006; DaSilva et al, 2011), implicating that they possess a distinct social behavior profile possibly related to their anxiety-like characteristics. WKYs also avoided the female stimulus rat compared to the other strains (particularly compared to the SHRs).…”

Section: Discussionmentioning

confidence: 99%

Learned helplessness and social avoidance in the Wistar-Kyoto rat

Nam

Clinton

Jackson

et al. 2014

Front. Behav. Neurosci.

118

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The Wistar-Kyoto (WKY) rat is an established depression model characterized by elevated anxiety- and depression-like behavior across a variety of tests. Here we further characterized specific behavioral and functional domains relevant to depression that are altered in WKY rats. Moreover, since early-life experience potently shapes emotional behavior, we also determined whether aspects of WKYs' phenotype were modifiable by early-life factors using neonatal handling or maternal separation. We first compared WKYs' behavior to that of Sprague–Dawley (SD), Wistar, and Spontaneously Hypertensive (SHR) rats in: the open field test, elevated plus maze, novelty-suppressed feeding test, a social interaction test, and the forced swim test (FST). WKYs exhibited high baseline immobility in the FST and were the only strain to show increased immobility on FST Day 2 vs. Day 1 (an indicator of learned helplessness). WKYs also showed greater social avoidance, along with enlarged adrenal glands and hearts relative to other strains. We next tested whether neonatal handling or early-life maternal separation stress influenced WKYs' behavior. Neither manipulation affected their anxiety- and depressive-like behaviors, likely due to a strong genetic underpinning of their phenotype. Our findings indicate that WKY rats are a useful model that captures specific functional domains relevant to clinical depression including: psychomotor retardation, behavioral inhibition, learned helplessness, social withdrawal, and physiological dysfunction. WKY rats appear to be resistant to early-life manipulations (i.e., neonatal handling) that are therapeutic in other strains, and may be a useful model for the development of personalized anti-depressant therapies for treatment resistant depression.

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“…There are numerous reports about acute effects of fear conditioning and other stressful events on sleep patterns in rodents (for a review, see Palma et al, 2000; Vazquez-Palacios and Velazquez-Moctezuma, 2000; Sanford et al, 2001, 2003a,b,c; Liu et al, 2003, 2009, 2011; Jha et al, 2005; Pawlyk et al, 2005, 2008; Madan et al, 2008; Wellman et al, 2008; Yang et al, 2009; Deschaux et al, 2010; Dasilva et al, 2011; Philbert et al, 2011). These studies differ substantially in crucial parameters such as the fear conditioning type, strength and frequency of conditioning, circadian time at conditioning, species, strain and gender of the animals, and their ambient light-dark-rhythm.…”

Section: Discussionmentioning

confidence: 99%

“…One common finding is that fear conditioning performed in the beginning of the inactive phase of the animals resulted in an acute (4–22 h after shock) decrease in REMS in rats (Palma et al, 2000; Sanford et al, 2001; Jha et al, 2005; Pawlyk et al, 2005; Liu et al, 2009, 2011; Yang et al, 2009; Deschaux et al, 2010) and mice (Liu et al, 2003; Sanford et al, 2003a,b,c; Wellman et al, 2008). However, a more detailed analysis of REMS architecture revealed a shock-related increase of sequential REMS episodes (interval between REMS episodes <3 min; Madan et al, 2008; DaSilva et al, 2011; Dasilva et al, 2011). Additionally, conditioning at the end of the active phase led to increased REMS in rats (Vazquez-Palacios and Velazquez-Moctezuma, 2000).…”

Section: Discussionmentioning

confidence: 99%

Prognostic and Symptomatic Aspects of Rapid Eye Movement Sleep in a Mouse Model of Posttraumatic Stress Disorder

Polta¹,

Fenzl²,

Jakubcakova³

et al. 2013

Front. Behav. Neurosci.

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Not every individual develops Posttraumatic Stress Disorder (PTSD) after the exposure to a potentially traumatic event. Therefore, the identification of pre-existing risk factors and early diagnostic biomarkers is of high medical relevance. However, no objective biomarker has yet progressed into clinical practice. Sleep disturbances represent commonly reported complaints in PTSD patients. In particular, changes in rapid eye movement sleep (REMS) properties are frequently observed in PTSD patients. Here, we examined in a mouse model of PTSD whether (1) mice developed REMS alterations after trauma and (2) whether REMS architecture before and/or shortly after trauma predicted the development of PTSD-like symptoms. We monitored sleep-wake behavior via combined electroencephalogram/electromyogram recordings immediately before (24 h pre), immediately after (0-48 h post) and 2 months after exposure to an electric foot shock in male C57BL/6N mice (n = 15). PTSD-like symptoms, including hyperarousal, contextual, and generalized fear, were assessed 1 month post-trauma. Shocked mice showed early onset and sustained elevation of REMS compared to non-shocked controls. In addition, REMS architecture before trauma was correlated with the intensity of acoustic startle responses, but not contextual fear, 1 month after trauma. Our data suggest REMS as prognostic (pre-trauma) and symptomatic (post-trauma) marker of PTSD-like symptoms in mice. Translated to the situation in humans, REMS may constitute a viable, objective, and non-invasive biomarker in PTSD and other trauma-related psychiatric disorders, which could guide pharmacological interventions in humans at high risk.

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Social partnering significantly reduced rapid eye movement sleep fragmentation in fear-conditioned, stress-sensitive Wistar-Kyoto rats

Cited by 15 publications

References 126 publications

Effects of different types of contingent tactile stimulation on crying, smiling, and sleep in newborns: An observational study

Effects of different types of contingent tactile stimulation on crying, smiling, and sleep in newborns: An observational study

Learned helplessness and social avoidance in the Wistar-Kyoto rat

Prognostic and Symptomatic Aspects of Rapid Eye Movement Sleep in a Mouse Model of Posttraumatic Stress Disorder

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