Social participation and quality of life among patients with neuromyelitis optica spectrum disorders: The mediating effects of depression

Wang, Tong; Ruan, Hengfang; Fan, Ping; Jia, Mengmeng; Qiu, Wei; Li, Kun; Li, Huijuan

doi:10.1016/j.msard.2021.103445

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…Our findings also filled the knowledge gap by examining the pathway in which social participation may buffer depressive symptoms, avoiding the development of activity impairment. Intervening only to increase social participation is not normally extremely effective in improving activity impairment [ 32 ]. Clinicians should consider the mediating role of depressive symptoms, and depressive symptoms can be enhanced through interventions, such as emotion regulation, meditation, and music therapy, to protect against activity impairment [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal relationship between social participation, depressive symptoms, and activity impairment among older patients with arthritis: a moderated mediation analysis

Yan,

Luan,

Meng

et al. 2024

BMC Geriatr

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Background Arthritis primarily affects older people and is a prominent cause of their activity impairment. This study aimed to examine the mediating role of depressive symptoms in the relationship between social participation and activity impairment, as well as to determine whether sex moderated the mediating effect. Methods A total of 2247 older patients with arthritis were included from the China Health and Retirement Longitudinal Study between 2015 and 2018. We first examined a simple mediation model where depressive symptoms were a mediator between social participation and activity impairment. Furthermore, sex was systematically integrated into the model as a moderator. The mediation model and moderated mediation model were analyzed using PROCESS macro. Results Mediation analysis revealed that the association between social participation and activity impairment was partially mediated by depressive symptoms (B = -0.10, 95% CI = [-0.14, -0.06]) with intermediary effect of 28.6%. Moderated mediation analysis indicated that mediation model was moderated by sex. The indirect effect of social participation on activity impairment among female patients (B = -0.15, 95% CI = [-0.21, -0.09]) was stronger than male patients (B = -0.04, 95% CI = [-0.09, -0.01]). Conclusion Social participation was the key protective factor associated with depressive symptoms and activity impairment among arthritis patients. Encouraging arthritis patients to social participation and improving the depressive symptoms might avoid activity impairment, especially for female patients.

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Section: Discussionmentioning

confidence: 99%

Longitudinal relationship between social participation, depressive symptoms, and activity impairment among older patients with arthritis: a moderated mediation analysis

Yan,

Luan,

Meng

et al. 2024

BMC Geriatr

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“…Evaluations of HRQoL are being used as outcome measures in clinical trials on NMOSD [ 30 – 32 ], and new studies are emerging worldwide. However, there is still a lack of research that focuses on HRQoL in patients diagnosed with this disorder [ 6 , 9 , 11 , 14 , 33 ]. Furthermore, patients with NMOSD also suffer from various symptoms like pain, fatigue, and depression, all of which can affect their quality of life and should be addressed.…”

Section: Discussionmentioning

confidence: 99%

“…We also found a high correlation between depression and the psychological and physical dimensions of the MSIS-29, while a more modest correlation was found with disability. These results highlight the need for active screening for psychologic disorders in this population group, offering early treatment and rehabilitation and thus improving HRQoL [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Neuromyelitis Optica Spectrum Disorder on Quality of Life from the Patients’ Perspective: An Observational Cross-Sectional Study

et al. 2022

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Introduction Neuromyelitis optica spectrum disorder (NMOSD) is associated with a reduced health-related quality of life (HRQoL). The purpose of this study was to describe the impact of NMOSD on HRQoL from the patients’ perspective and its relationship with other disease factors. Methods An observational, cross-sectional study was conducted at 13 neuroimmunology clinics in Spain. Patients with NMOSD diagnosis (2015 Wingerchuk criteria) were included. The 29-item Multiple Sclerosis Impact Scale (MSIS-29) was used to assess the HRQoL. Different questionnaires were used to measure symptom severity, stigma, mood disorders, pain, fatigue, and difficulties in the workplace. Factors that impact HRQoL were identified by Spearman’s correlation and multivariate linear regression analysis. Results Seventy-one patients were included (mean age 47.4 ± 14.9 years, 80.3% female, mean time since disease onset 9.9 ± 8.1 years). The median Expanded Disability Status Scale score was 3.0 (1.5–4.5). The mean (± SD) physical and psychological MSIS-29 sub-scores were 41.9 ± 16.8 and 20.9 ± 8.3, respectively. Fatigue and body pain were the most prevalent symptoms. Depressive symptoms were found in 44.3% ( n = 31) of patients. The physical MSIS-29 dimension showed the highest correlation with symptom severity ( ρ = 0.85584, p < 0.0001), whereas the highest correlations for psychological MSIS-29 dimension were pain, MSIS-29 physical dimension, and depression ( ρ = 0.76487, 0.72779, 0.71380; p < 0.0001, respectively). Pain was a predictor of both dimensions of MSIS-29. Conclusion Fatigue, pain, and depressive symptoms are frequent problems among patients with NMOSD, impacting on their quality of life. Assessment of patient-oriented outcomes may be useful to achieve a holistic approach, allowing early specific interventions.

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“…All the scales used in the present study have been utilized in previous NMOSD studies [ 13 , 14 , 22 – 24 ]. All the Chinese versions of these scales have been validated previously [ 25 – 29 ].…”

Section: Methodsmentioning

confidence: 99%

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

Yang

Xie

et al. 2023

BMC Neurol

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Background This study aimed to investigate the clinical risk factors of dysautonomic symptom burden in neuromyelitis optica spectrum disorder (NMOSD) and its impact on patients’ quality of life. Methods A total of 63 NMOSD patients and healthy controls were enrolled. All participants completed the Composite Autonomic Symptom Score 31 (COMPASS-31) to screen for symptoms of autonomic dysfunction. A comprehensive clinical evaluation was performed on NMOSD patients, such as disease characteristics and composite evaluations of life status, including quality of life, anxiety/depression, sleep, and fatigue. Correlated factors of dysautonomic symptoms and quality of life were analyzed. Results The score of COMPASS-31 in the NMOSD group was 17.2 ± 10.3, significantly higher than that in healthy controls (P = 0.002). In NMOSD patients, the higher COMPASS-31 score was correlated with more attacks (r = 0.49, P < 0.001), longer disease duration (r = 0.52, P < 0.001), severer disability (r = 0.50, P < 0.001), more thoracic cord lesions (r = 0.29, P = 0.02), more total spinal cord lesions (r = 0.35, P = 0.005), severer anxiety (r = 0.55, P < 0.001), severer depression (r = 0.48, P < 0.001), severer sleep disturbances (r = 0.59, P < 0.001), and severer fatigue (r = 0.56, P < 0.001). The disability, total spinal cord lesions, and fatigue were revealed to be independently associated factors. Further analysis revealed that the COMPASS-31 score was independently correlated with scores of all the domains of patients’ quality of life scale (P < 0.05). Conclusions Dysautonomic symptom burden is correlated with decreased quality of life and certain clinical characteristics such as disability, the burden of spinal cord lesions, and fatigue in NMOSD patients. Investigation and proper management of autonomic dysfunction may help to improve the quality of life in patients with NMOSD.

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Social participation and quality of life among patients with neuromyelitis optica spectrum disorders: The mediating effects of depression

Cited by 8 publications

References 23 publications

Longitudinal relationship between social participation, depressive symptoms, and activity impairment among older patients with arthritis: a moderated mediation analysis

Longitudinal relationship between social participation, depressive symptoms, and activity impairment among older patients with arthritis: a moderated mediation analysis

Impact of Neuromyelitis Optica Spectrum Disorder on Quality of Life from the Patients’ Perspective: An Observational Cross-Sectional Study

Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients

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