Social Odor Recognition: A Novel Behavioral Model for Cognitive Dysfunction in Parkinson’s Disease

Monaghan, Michael M.; Leddy, Lauren; Sung, Mei-Li A.; Albinson, Kristin; Kubek, Katie; Pangalos, Menelas N.; Reinhart, Peter H.; Zaleska, Margaret M.; Comery, Thomas A.

doi:10.1159/000289227

Cited by 11 publications

(3 citation statements)

References 46 publications

(28 reference statements)

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“…Damage to midbrain DA neurons causes a loss of striatal DA terminals, which produces equivalent changes in striatal levels of presynaptic dopamine transporter and TH [23, 29, 30]. Similar to previous reports by our lab and others [25, 26, 31, 32], MPTP decreased TH immunoreactivity in the striatum (Figures 1(a) and 1(b), n = 8 − 10/group).…”

Section: Resultssupporting

confidence: 88%

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

Antzoulatos

Jakowec

Petzinger

et al. 2011

Parkinson's Disease

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Nigrostriatal damage is increased in males relative to females. While estrogen is neuroprotective in females, less is known about potential protective effects of testosterone in males. We determined if castration enhances neuronal injury to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Castrates or sham-castrated mice were sacrificed 1 week following injection of MPTP (4 × 20 mg/kg) or saline (n = 11-12/group). The right striatum was immunostained for tyrosine hydroxylase (TH). The left hemisphere was stained by Golgi Cox to quantify neuronal morphology in medium spiny neurons (MSNs) of the dorsolateral striatum. MPTP reduced TH, but there was no effect of castration and no interaction. For MSN dendritic morphology, MPTP decreased the highest branch order and increased spine density on 2nd-order dendrites. Castrated males had shorter 5th-order dendrites. However, there was no interaction between gonadal status and MPTP. Thus, castration and MPTP exert nonoverlapping effects on MSN morphology with castration acting on distal dendrites and MPTP acting proximally.

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Section: Resultssupporting

confidence: 88%

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

Antzoulatos

Jakowec

Petzinger

et al. 2011

Parkinson's Disease

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“…MPTP-treated models did not develop long-term changes in locomotive and cognitive function ( Fifel et al, 2013 ). Most studies have suggested that an MPTP-treated rodent model induces specific types of cognitive impairment, which include deficits in short-term spatial learning, working memory, memory acquisition and retention, short-term social and object recognition memory, short-term inhibitory avoidance memory, contextual memory, visuospatial attention, and episodic-like memory ( Monaghan et al, 2010 ; Wang et al, 2010 ; Castro et al, 2012 ; Das et al, 2014 ; Ho et al, 2014 ; Yabuki et al, 2014 ; Zhang et al, 2018 ; Yang et al, 2020 ).…”

Section: Neurotoxin-induced Experimental Models Of Cognitive Impairmentmentioning

confidence: 99%

Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal

Fan

Han

Zhao

et al. 2021

Front. Aging Neurosci.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease. Cognitive impairment is one of the key non-motor symptoms of PD, affecting both mortality and quality of life. However, there are few experimental studies on the pathology and treatments of PD with mild cognitive impairment (PD-MCI) and PD dementia (PDD) due to the lack of representative models. To identify new strategies for developing representative models, we systematically summarized previous studies on PD-MCI and PDD and compared differences between existing models and diseases. Our initial search identified 5432 articles, of which 738 were duplicates. A total of 227 articles met our inclusion criteria and were included in the analysis. Models fell into three categories based on model design: neurotoxin-induced, transgenic, and combined. Although the neurotoxin-induced experimental model was the most common type that was used during every time period, transgenic and combined experimental models have gained significant recent attention. Unfortunately, there remains a big gap between ideal and actual experimental models. While each model has its own disadvantages, there have been tremendous advances in the development of PD models of cognitive impairment, and almost every model can verify a hypothesis about PD-MCI or PDD. Finally, our proposed strategies for developing novel models are as follows: a set of plans that integrate symptoms, biochemistry, neuroimaging, and other objective indicators to judge and identify that the novel model plays a key role in new strategies for developing representative models; novel models should simulate different clinical features of PD-MCI or PDD; inducible α-Syn overexpression and SH-SY5Y-A53T cellular models are good candidate models of PD-MCI or PDD.

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“…A novel object recognition test was used to evaluate the cognitive function of the rats [52]. The test included three steps as previously reported [53,54]. (1) Habituation phase: In preparation for the odor recognition task, several 2.5 cm diameter round wooden beads with a 0.2 cm hole bored through their diameter (Woodworks Ltd.; Haltom City, TX, USA) were labeled with a unique identifier.…”

Section: Novel Object Recognition Testmentioning

confidence: 99%

Delayed Minocycline Treatment Ameliorates Hydrocephalus Development and Choroid Plexus Inflammation in Spontaneously Hypertensive Rats

Hao¹,

Ye²,

Holste³

et al. 2022

IJMS

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Hydrocephalus is a complicated disorder that affects both adult and pediatric populations. The mechanism of hydrocephalus development, especially when there is no mass lesion present causing an obstructive, is poorly understood. Prior studies have demonstrated that spontaneously hypertensive rats (SHRs) develop hydrocephalus by week 7, which was attenuated with minocycline. The aim of this study was to determine sex differences in hydrocephalus development and to examine the effect of minocycline administration after hydrocephalus onset. Male and female Wistar–Kyoto rats (WKYs) and SHRs underwent magnetic resonance imaging at weeks 7 and 9 to determine ventricular volume. Choroid plexus epiplexus cell activation, cognitive deficits, white matter atrophy, and hippocampal neuronal loss were examined at week 9. In the second phase of the experiment, male SHRs (7 weeks old) were treated with either saline or minocycline (20 mg/kg) for 14 days, and similar radiologic, histologic, and behavior tests were performed. Hydrocephalus was present at week 7 and increased at week 9 in both male and female SHRs, which was associated with greater epiplexus cell activation than WKYs. Male SHRs had greater ventricular volume and epiplexus cell activation compared to female SHRs. Minocycline administration improved cognitive function, white matter atrophy, and hippocampal neuronal cell loss. In conclusion, while both male and female SHRs developed hydrocephalus and epiplexus cell activation by week 9, it was more severe in males. Delayed minocycline treatment alleviated hydrocephalus, epiplexus macrophage activation, brain pathology, and cognitive impairment in male SHRs.

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Social Odor Recognition: A Novel Behavioral Model for Cognitive Dysfunction in Parkinson’s Disease

Cited by 11 publications

References 46 publications

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal

Delayed Minocycline Treatment Ameliorates Hydrocephalus Development and Choroid Plexus Inflammation in Spontaneously Hypertensive Rats

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