Current challenges in TB control efforts, such as an unprepared public health system leadership and infrastructure and an overwhelmed health care workforce, will require novel approaches, practices, and renewed political commitment to maintain sustainable TB programs.We described proposed recommendations that may strengthen health system preparedness for optimal TB control across low-and middle-income countries: n Ensuring leadership and governance for sustainable national health care budgets n Building networks of community stakeholders n Supporting high-quality health care workforce training and safe workplace environments n Using digital health interventions for TB care Key Implications n National health systems should develop national policies that promote integral, patient-centered TB care, facilitate the implementation of ethical community interventions, support operational research, and allow the integration of appropriate eHealth applications. n Program managers who understand challenges in TB prevention and control with coexisting health priorities can serve as instrumental leaders and patient advocates to deliver high-quality and sustainable TB care that leads to achieving targets of the End TB Strategy.