Social jetlag, sleep‐related parameters, and glycemic control in adults with type 1 diabetes: Results of a cross‐sectional study

Abstract

Background Social jetlag (SJL) is a small recurrent circadian rhythm disruption and the most frequent form of circadian rhythm misalignment. The main aim of this study was to investigate the effect of SJL on glycemic control, as assessed by HbA1c, in real‐life settings. Methods In all, 115 consecutive patients with type 1 diabetes (T1D) were analyzed cross‐sectionally. Data on bedtime, sleep onset latency, and wake up time on weekdays and weekends during the previous month were collected from all participants and used to calculate SJL, chronotype, and sleep duration. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). A PSQI score > 5 was considered as an indicator of poor sleep quality. Results Patients with SJL ≥ 1 hour had significantly higher adjusted values of HbA1c than those with SJL <1 hour (8.7% vs 8.0%; P = 0.029). In unadjusted multivariate regression analysis, SJL ≥ 1 hour and poor sleep quality were significant predictors of HbA1c values, explaining 22.7% and 23.5%, respectively, of the increase in HbA1c. After adjusting for age, sex, diabetes duration, insulin dose (kg/d), insulin regimen and body mass index, only SJL ≥ 1 hour remained associated with HbA1c (β = 0.253; P = 0.026). There was no significant interaction between SJL ≥ 1 hour and poor sleep quality in either the unadjusted or adjusted models (Pinteraction = 0.914). Conclusions In patients with T1D, SJL is associated with poor glycemic control, acting independently of sleep quality, sleep duration, and chronotype to exert a deleterious effect on glycemic control.

Does sleep duration, napping, and social jetlag predict hemoglobin A1c among college students with type 1 diabetes mellitus?

“…On the other hand, our results found no relationship between HbA1c levels and weekend sleep duration and social jetlag among college students with T1DM. The discrepancies between our finding and previous studies [24,43] could be due to our small sample size and lack of statistical power. Thus, more research with a larger sample size is warranted.…”

“…Our results found no statistical gender differences among college students with T1DM, however, males selfreported longer sleep duration (weekdays and weekends) and increased napping and social jetlag. Also, social jetlag was associated with an increase in HbA1c among adults with T1DM [43] and T2DM [24]. On the other hand, our results found no relationship between HbA1c levels and weekend sleep duration and social jetlag among college students with T1DM.…”

The Association of Cardiometabolic Disease with Psychological Factors in Colombian People during the COVID-19 Pandemic: A Cross-Sectional Study

“…Each of the questions in this questionnaire has a scale that ranges from 0 to 3, where poorer sleep quality is indicated by higher scores and the total score ranges from 0 to 21, with poor sleep quality being scores > 5 [ 43 , 44 , 45 ]. Taking into account that other studies used a cut-off score of 5 points, in the global PSQI score, to categorize people with or without sleep disorders [ 35 , 46 ]. In this research, for both groups, those evaluated were classified according to whether or not they presented with low sleeping quality (LSQ) in such a way that people with scores < 5 were categorized as without LSQ, while those with scores ≥ 5 were grouped in the with LSQ category.…”

“…On the other hand, positive associations between obesity, high blood pressure and hyperglycemia with a longer duration of sleep were described in the Arab population [ 33 ]. In people with type 1 and 2 diabetes, both the amount of sleep and the quality of sleep were found to be essential for glycemic control and metabolic function [ 34 , 35 ], and some evidence suggests that lack of sleep would play an important role in the development of type 2 diabetes mellitus, mediated by obesity and by alterations in the regulation of leptin [ 36 ].…”

Associação entre jet lag social e resposta metabólica, antropométrica e do consumo alimentar de pacientes submetidos à cirurgia bariátrica: um estudo observacional e longitudinal

“…Other studies also identified a strong negative effect of SJL on the metabolic profile, such as increases in serum triglyceride levels [19,14], TC (14), fasting insulin and HOMA-IR, besides, decreased serum HDL levels [19], as well as elevated levels of fasting glucose [16,14], increased risk for high glycated hemoglobin [15,54] and a deterioration in glycaemic control in diabetic patients [54]. Further studies with bariatric patients over a longer follow-up should evaluate the effect of SJL on the response of metabolic markers to confirm or discard the results presented in this study.…”