Social isolation mediated anxiety like behavior is associated with enhanced expression and regulation of BDNF in the female mouse brain

Kumari, Anita; Singh, Padmanabh; Baghel, Meghraj Singh; Thakur, M. K.

doi:10.1016/j.physbeh.2016.02.032

Cited by 45 publications

(36 citation statements)

References 65 publications

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“…Previous studies on leukocyte of elderly human being have revealed some connections between social loneliness to immune system gene expression changes [ 14 ]. A study on mice shows [ 49 ] showing upregulated brain-derived neurotrophic factor upon social isolation. We tracked the changes in gene expression over social isolation time and found that changes in gene expression occurred very early together with, and even before some of, the behavioral changes.…”

Section: Discussionmentioning

confidence: 99%

A simple computer vision pipeline reveals the effects of isolation on social interaction dynamics in Drosophila

et al. 2018

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Isolation profoundly influences social behavior in all animals. In humans, isolation has serious effects on health. Drosophila melanogaster is a powerful model to study small-scale, temporally-transient social behavior. However, longer-term analysis of large groups of flies is hampered by the lack of effective and reliable tools. We built a new imaging arena and improved the existing tracking algorithm to reliably follow a large number of flies simultaneously. Next, based on the automatic classification of touch and graph-based social network analysis, we designed an algorithm to quantify changes in the social network in response to prior social isolation. We observed that isolation significantly and swiftly enhanced individual and local social network parameters depicting near-neighbor relationships. We explored the genome-wide molecular correlates of these behavioral changes and found that whereas behavior changed throughout the six days of isolation, gene expression alterations occurred largely on day one. These changes occurred mostly in metabolic genes, and we verified the metabolic changes by showing an increase of lipid content in isolated flies. In summary, we describe a highly reliable tracking and analysis pipeline for large groups of flies that we use to unravel the behavioral, molecular and physiological impact of isolation on social network dynamics in Drosophila.

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Section: Discussionmentioning

confidence: 99%

A simple computer vision pipeline reveals the effects of isolation on social interaction dynamics in Drosophila

et al. 2018

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“…Social isolation-induced anxiety resulted in elevated BDNF expression in the cerebral cortex of mice (Kumari et al, 2016), whereas offspring of dams exposed to gestational stress showed reduced BDNF levels in blood (Zheng et al, 2016). Also, anxiety-like behaviors induced by monosodium glutamate (Rosa et al, 2016) and amnestic effects by MK-801 (Hill et al, 2015) reduced BDNF expression in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats

Lee

Park

Lin

et al. 2016

IJNPPY

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Background:Previous studies suggested that opiate withdrawal may increase anxiety and disrupt brain-derived neurotrophic factor function, but the effects of i.v. morphine self-administration on these measures remain unclear.Methods:Adult male Sprague-Dawley rats were implanted with a catheter in the jugular vein. After 1 week of recovery, the animals were allowed to self-administer either i.v. morphine (0.5 mg/kg per infusion, 4 h/d) or saline in the operant conditioning chambers. The acoustic startle reflex and prepulse inhibition were measured at a baseline and on self-administration days 1, 3, 5, and 7 (1- and 3-hour withdrawal). Blood samples were collected on self-administration days 3, 5, and 7 from separate cohorts of animals, and the levels of brain-derived neurotrophic factor and corticosterone were assayed using the enzyme-linked immunosorbent assay method.Results:Compared with the saline group, the morphine self-administration group showed hyper-locomotor activity and reduced defecation during the self-administration. The morphine self-administration increased acoustic startle reflex at 1-hour but not 3-hour withdrawal from morphine and disrupted prepulse inhibition at 3-hour but not 1-hour withdrawal. The blood brain-derived neurotrophic factor levels were decreased in the morphine self-administration group at self-administration days 3 and 5, while the corticosterone levels remained unchanged throughout the study.Conclusions:The current findings suggest that spontaneous withdrawal from i.v. morphine self-administration may have transient effects on acoustic startle, sensorimotor gating, and peripheral brain-derived neurotrophic factor levels, and these changes may contribute to the adverse effects of opiate withdrawal.

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“…However, several groups have reported similar behavioral changes in mice that have been socially isolated in adolescence. For example, adolescent social isolation in mice has been shown to lead to increases in anxiety‐like behavior on the elevated‐plus maze (Koike et al ; Kumari et al ; Wei et al , although see Voikar et al ; Zhang et al ), sensory gating deficits (Gan et al ) as well as increased contextual fear and impaired fear extinction (Liu et al ; Pibiri et al ). Other studies have reported increases in home‐cage ethanol intake and preference (Advani et al ; Lopez et al ; Talani et al ), with one of these studies showing that this effect endured for at least 1 month into adulthood (Advani et al ).…”

Section: Modeling Comorbid Ptsd and Aud In Animalsmentioning

confidence: 99%

Neurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder

Gilpin

Weiner

2016

Genes Brain and Behavior

116

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Post-traumatic stress disorder (PTSD) and alcohol-use disorder (AUD) are highly comorbid in humans. Although we have some understanding of the structural and functional brain changes that define each of these disorders, and how those changes contribute to the behavioral symptoms that define them, little is known about the neurobiology of comorbid PTSD and AUD, which may be due in part to a scarcity of adequate animal models for examining this research question. The goal of this review is to summarize the current state-of-the-science on comorbid PTSD and AUD. We summarize epidemiological data documenting the prevalence of this comorbidity, review what is known about the potential neurobiological basis for the frequent co-occurrence of PTSD and AUD and discuss successes and failures of past and current treatment strategies. We also review animal models that aim to examine comorbid PTSD and AUD, highlighting where the models parallel the human condition, and we discuss the strengths and weaknesses of each model. We conclude by discussing key gaps in our knowledge and strategies for addressing them: in particular, we (1) highlight the need for better animal models of the comorbid condition and better clinical trial design, (2) emphasize the need for examination of subpopulation effects and individual differences and (3) urge cross-talk between basic and clinical researchers that is reflected in collaborative work with forward and reverse translational impact.

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Social isolation mediated anxiety like behavior is associated with enhanced expression and regulation of BDNF in the female mouse brain

Cited by 45 publications

References 65 publications

A simple computer vision pipeline reveals the effects of isolation on social interaction dynamics in Drosophila

A simple computer vision pipeline reveals the effects of isolation on social interaction dynamics in Drosophila

Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats

Neurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder

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