Social isolation impairs the persistence of social recognition memory by disturbing the glutamatergic tonus and the olfactory bulb-dorsal hippocampus coupling

Almeida-Santos, Ana Flávia; Carvalho, Vinícius Rezende; Jaimes, Laura F.; Castro, Caio M. de; Pinto, Hyorrana Priscila Pereira; Oliveira, Tadeu P. D.; Vieira, Luciene Bruno; Moraes, Márcio Flávio Dutra; Pereira, Grace Schenatto

doi:10.1038/s41598-018-36871-6

Cited by 29 publications

(19 citation statements)

References 98 publications

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“…We showed recently that OB theta oscillations drive dorsal hippocampus gamma amplitude during long-term social memory retrieval. This OB-dHIP coupling was impaired in SI mice during memory retrieval 37 . Taken together, we may speculate that FLX has recovered the social memory deficit by reinstating OB-dHIP coupling, though a new study is needed to test this hypothesis.…”

Section: Discussionmentioning

confidence: 85%

“…One emerging field that has been the focus of our research is to understand the effects of SI on a specific type of episodic memory named social recognition memory 23,34 . One week of SI is deleterious for the longterm maintenance of social memory in mice [35][36][37] , although did not affect other hippocampus-dependent memories 36 . Interestingly, enriched environment blunted the effect of SI on memory 36 in a neurogenesis-dependent manner 38 .…”

Section: Introductionmentioning

confidence: 85%

“…There is evidence suggesting that SI affects males and females differentially 51 . Therefore, before assessing whether the social memory deficit caused by SI in male mice [36][37][38] is accompanied by depressive-like behavior, we tested female mice in the social recognition task after 1 week of SI. We conducted experiments ( Fig.…”

Section: Si Does Not Compromise Social Recognition Memory In Female Micementioning

confidence: 99%

“…1c) social memory in female mice. We chose to test STM because it was the first time we tested females, and we know that SI did not compromise STM in males [36][37][38] . In the STM, there was no difference between groups (t (13) = 0.5, p = 0.58).…”

Section: Si Does Not Compromise Social Recognition Memory In Female Micementioning

confidence: 99%

“…Neurochemical unbalance may also be present in humans 18,19 and rodents 21,[35][36][37] under a depressive state. Particularly serotonin (5-HT) and NE levels may be disturbed in those situations 18,20,36 .…”

Section: Decreased Ne Levels and Reduced Ob Volume In Socially Isolatmentioning

confidence: 99%

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Pro-neurogenic effect of fluoxetine in the olfactory bulb is concomitant to improvements in social memory and depressive-like behavior of socially isolated mice

Medeiros

et al. 2020

Transl Psychiatry

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Although loneliness is a human experience, it can be estimated in laboratory animals deprived from physical contact with conspecifics. Rodents under social isolation (SI) tend to develop emotional distress and cognitive impairment. However, it is still to be determined whether those conditions present a common neural mechanism. Here, we conducted a series of behavioral, morphological, and neurochemical analyses in adult mice that underwent to 1 week of SI. We observed that SI mice display a depressive-like state that can be prevented by enriched environment, and the antidepressants fluoxetine (FLX) and desipramine (DES). Interestingly, chronic administration of FLX, but not DES, was able to counteract the deleterious effect of SI on social memory. We also analyzed cell proliferation, neurogenesis, and astrogenesis after the treatment with antidepressants. Our results showed that the olfactory bulb (OB) was the neurogenic niche with the highest increase in neurogenesis after the treatment with FLX. Considering that after FLX treatment social memory was rescued and depressive-like behavior decreased, we propose neurogenesis in the OB as a possible mechanism to unify the FLX ability to counteract the deleterious effect of SI.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 85%

Section: Si Does Not Compromise Social Recognition Memory In Female Micementioning

confidence: 99%

Section: Si Does Not Compromise Social Recognition Memory In Female Micementioning

confidence: 99%

Section: Decreased Ne Levels and Reduced Ob Volume In Socially Isolatmentioning

confidence: 99%

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Pro-neurogenic effect of fluoxetine in the olfactory bulb is concomitant to improvements in social memory and depressive-like behavior of socially isolated mice

Medeiros

et al. 2020

Transl Psychiatry

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SRF depletion in early life contributes to social interaction deficits in the adulthood

Roszkowska

Krysiak

Majchrowicz

et al. 2022

Cell. Mol. Life Sci.

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Alterations in social behavior are core symptoms of major developmental neuropsychiatric diseases such as autism spectrum disorders or schizophrenia. Hence, understanding their molecular and cellular underpinnings constitutes the major research task. Dysregulation of the global gene expression program in the developing brain leads to modifications in a number of neuronal connections, synaptic strength and shape, causing unbalanced neuronal plasticity, which may be important substrate in the pathogenesis of neurodevelopmental disorders, contributing to their clinical outcome. Serum response factor (SRF) is a major transcription factor in the brain. The behavioral influence of SRF deletion during neuronal differentiation and maturation has never been studied because previous attempts to knock-out the gene caused premature death. Herein, we generated mice that lacked SRF from early postnatal development to precisely investigate the role of SRF starting in the specific time window before maturation of excitatory synapses that are located on dendritic spine occurs. We show that the time-controlled loss of SRF in neurons alters specific aspects of social behaviors in SRF knock-out mice, and causes deficits in developmental spine maturation at both the structural and functional levels, including downregulated expression of the AMPARs subunits GluA1 and GluA2, and increases the percentage of filopodial/immature dendritic spines. In aggregate, our study uncovers the consequences of postnatal SRF elimination for spine maturation and social interactions revealing novel mechanisms underlying developmental neuropsychiatric diseases.

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Olfactory Dysfunction in Diabetic Rats is Associated with miR-146a Overexpression and Inflammation

et al. 2020

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Social isolation impairs the persistence of social recognition memory by disturbing the glutamatergic tonus and the olfactory bulb-dorsal hippocampus coupling

Cited by 29 publications

References 98 publications

Pro-neurogenic effect of fluoxetine in the olfactory bulb is concomitant to improvements in social memory and depressive-like behavior of socially isolated mice

Pro-neurogenic effect of fluoxetine in the olfactory bulb is concomitant to improvements in social memory and depressive-like behavior of socially isolated mice

SRF depletion in early life contributes to social interaction deficits in the adulthood

Olfactory Dysfunction in Diabetic Rats is Associated with miR-146a Overexpression and Inflammation

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