Abstract:The nigrostriatal system composed of the dorsal striatum and the
substantia nigra (SN) is highly involved in the control of motor
behavior. Various extremal and pathological conditions as well as social
isolation may cause an impairment of locomotor function; however,
corresponding alterations in the nigrostriatal dopaminergic pathway are
far from full understanding. Here we analyzed the effect of 3-day
hindlimb unloading (HU) and social isolation (SI) on the key players of
dopamine transmission in the nigrost… Show more
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