Social isolation and the brain in the pandemic era

Bzdok, Danilo; Dunbar, R. I. M.

doi:10.1038/s41562-022-01453-0

Cited by 58 publications

(45 citation statements)

References 134 publications

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“…The limitation of this approach is that it does not account for the diversity of environmental conditions in the real world, which can modify or mediate some of the associations that are being studied. For example, a range of observational and experimental approaches have shown that social connections influence mental health problems across the life span–not only relative to their risk of onset, but also their subsequent course and biological correlates ( Bzdok and Dunbar, 2020 , 2022 ). Including such social determinants in multiomics models would allow controlling for variation that might otherwise be misinterpreted as measurement error, random variation or “noise” and improve the detection of causal relationships.…”

Section: Challenges To Precision In Psychiatric Research and Practicementioning

confidence: 99%

Restoring the missing person to personalized medicine and precision psychiatry

et al. 2023

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Precision psychiatry has emerged as part of the shift to personalized medicine and builds on frameworks such as the U.S. National Institute of Mental Health Research Domain Criteria (RDoC), multilevel biological “omics” data and, most recently, computational psychiatry. The shift is prompted by the realization that a one-size-fits all approach is inadequate to guide clinical care because people differ in ways that are not captured by broad diagnostic categories. One of the first steps in developing this personalized approach to treatment was the use of genetic markers to guide pharmacotherapeutics based on predictions of pharmacological response or non-response, and the potential risk of adverse drug reactions. Advances in technology have made a greater degree of specificity or precision potentially more attainable. To date, however, the search for precision has largely focused on biological parameters. Psychiatric disorders involve multi-level dynamics that require measures of phenomenological, psychological, behavioral, social structural, and cultural dimensions. This points to the need to develop more fine-grained analyses of experience, self-construal, illness narratives, interpersonal interactional dynamics, and social contexts and determinants of health. In this paper, we review the limitations of precision psychiatry arguing that it cannot reach its goal if it does not include core elements of the processes that give rise to psychopathological states, which include the agency and experience of the person. Drawing from contemporary systems biology, social epidemiology, developmental psychology, and cognitive science, we propose a cultural-ecosocial approach to integrating precision psychiatry with person-centered care.

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Section: Challenges To Precision In Psychiatric Research and Practicementioning

confidence: 99%

Restoring the missing person to personalized medicine and precision psychiatry

et al. 2023

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“…2a). Many lines of evidence suggest that we will face more mental health concerns due to chronic social isolation and stress 15 . Recent evidence documented the detrimental effect of COVID-19 on minority and marginalized strata of the US population 16 .…”

Section: Commentmentioning

confidence: 99%

The end game: respecting major sources of population diversity

2023

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“…The Covid-19 outbreak began in early 2020, followed by a massive pandemic lockdown across the globe, leading to rapid changes in our social lives (1). During the pandemic lockdown period, individuals were isolated from their daily face-to-face social interactions and asked to remain within their limited indoor spaces (2).…”

Section: Introductionmentioning

confidence: 99%

Social isolation strengthens the association between intersubject similarity in fantasy and similarity in affective appraisal

Kuo¹,

Chou²,

Chen³

2023

Preprint

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The Covid-19 pandemic lockdown had led to unusually mas- sive social isolation that lasted for months around the world. In order to compensate for the poverty of social life, individ- uals are likely to shift their attention from their regular social world to their inner imaginative world during this lockdown pe- riod. Thus, the purpose of this study is to investigate whether intersubject similarity in individuals’ imaginative abilities (i.e., fantasy tendency) is associated with their similarity in affective ratings of the videos they watched, and whether this associa- tion is enhanced during the pandemic lockdown period. We recruited one lockdown group and two post-lockdown groups to test the above hypothesis. During the experiment, partici- pants were asked to watch a series of videos covering a wide range of topics, and then they were asked to complete several affective appraisal ratings (e.g., liking or feeling of resonance) of each video. We then used intersubject representational similar- ity analysis (ISRSA) to map the intersubject similarity in their fantasy tendency onto their similarity in the affective appraisal ratings. Our results showed that those who were more simi- lar in their fantasy scores also showed more similarity in their affective appraisals of videos. Most importantly, this fantasy- appraisal association was particularly strong in the lockdown group, but rather weak in the post-lockdown groups. Our find- ings suggest that individual differences in their imaginative abil- ities would become a crucial factor influencing how individuals appraise their inner world during social isolation. The current study may provide an example for policymakers on how to as- sess the impact of social isolation as we may face another wave of pandemics in the future.

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Social isolation and the brain in the pandemic era

Cited by 58 publications

References 134 publications

Restoring the missing person to personalized medicine and precision psychiatry

Restoring the missing person to personalized medicine and precision psychiatry

The end game: respecting major sources of population diversity

Social isolation strengthens the association between intersubject similarity in fantasy and similarity in affective appraisal

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