Social Isolation and Stress-related Cardiovascular, Lipid, and Cortisol Responses

Grant, Nina; Hamer, Mark; Steptoe, Andrew

doi:10.1007/s12160-009-9081-z

Cited by 214 publications

(168 citation statements)

References 58 publications

(74 reference statements)

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“…Our study supports the hypothesis that ADAR1 is altered in mice affected by social isolation stress-induced Social isolation defined as an objective reduced social contact (Khodaie et al, 2015) is a kind of psychosocial stressor (O'Keefe et al, 2014;Barratt et al, 2011). Reports from both humans (Grant et al, 2009) and rodent models (Fone and Porkess, 2008) suggest that social isolation leads to cognitive dysfunction (Yusufishaq & Rosenkranz, 2013). So far, the mechanisms of social isolation stress-induced cognitive deficits are not clarified completely.…”

Section: Altered Adar1 In Mice Affected By Social Isolation Stressindsupporting

confidence: 86%

Altered ADAR1 in mice affected by social isolation stress-induced cognitive deficits

Chen

et al. 2016

Preprint

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Altered ADAR1 in mice affected by social isolation stressinduced cognitive deficitsAdenosine deaminase acting on RNA (ADAR) activity increases in response to inflammation. Social isolation stress is related to neuroinflammation; however, it remains unclear whether ADAR1 is altered in response to social isolation stress-induced cognitive deficits. To investigate our hypothesis that ADAR1 displayed patterns of change in response to social isolation stress, we addressed this issue systemically by isolating Kunming mice for 2, 4 and 8 weeks individually since postnatal 21 days to set up isolation mouse model. Furthermore, we arranged re-socialization group to evaluate the alterations of ADAR1 in the cognitive deficits recovery. The results of behavior tests showed that social isolation stress resulted in cognitive dysfunction, which was recovered by resocialization in re-gregarious rearing group. Furthermore, the immunohistochemistry and western blot results displayed that both the immunoreactivity and protein expression of ADAR1 in the hippocampus and frontal cortex increased obviously as compared to the same age mice without isolation. The above abnormal alterations of ADAR1 were recovered by re-socialization in re-gregarious rearing group. Our study supports the hypothesis that ADAR1 is altered in mice affected by social isolation stress-induced Social isolation stress is related to neuroinflammation; however, it remains unclear whether ADAR1 alters in response to social isolation stress-induced cognitive deficits. To investigate our hypothesis that ADAR1 displayed patterns of change in response to social isolation stress, we addressed this issue systemically by isolating Kunming mice for 2, 4 and 8 weeks individually since postnatal 21 days to set up isolation mouse model. Furthermore, we arranged re-socialization group to evaluate the alterations of ADAR1 in the cognitive deficits recovery. The results of behavior tests showed that social isolation stress resulted in cognitive dysfunction, which was recovered by re-socialization in re-gregarious rearing group. Furthermore, the immunohistochemistry and western blot results displayed that both the immunoreactivity and protein expression of ADAR1 in the hippocampus and frontal cortex increased obviously as compared to the same age mice without isolation. The above abnormal alterations of ADAR1 were recovered by re-socialization in re-gregarious rearing group. Our study supports the hypothesis that ADAR1 is altered in the social isolation stress-induced cognitive deficits.

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Section: Altered Adar1 In Mice Affected By Social Isolation Stressindsupporting

confidence: 86%

Altered ADAR1 in mice affected by social isolation stress-induced cognitive deficits

Chen

et al. 2016

Preprint

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“…In addition, people who live alone or lack social contacts may be at increased risk of death if acute symptoms develop, because there is less of a network of confidantes to prompt medical attention (9). Social contact itself also may have specific biological consequences that are important for health maintenance (10)(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

“…Socially isolated individuals are at increased risk for the development of cardiovascular disease (3), infectious illness (4), cognitive deterioration (5), and mortality (6)(7)(8)(9). Social isolation also has been associated with elevated blood pressure, C-reactive protein, and fibrinogen (10, 11) and with heightened inflammatory and metabolic responses to stress (12,13).…”

mentioning

confidence: 99%

Social isolation, loneliness, and all-cause mortality in older men and women

Steptoe

Shankar

Demakakos

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Both social isolation and loneliness are associated with increased mortality, but it is uncertain whether their effects are independent or whether loneliness represents the emotional pathway through which social isolation impairs health. We therefore assessed the extent to which the association between social isolation and mortality is mediated by loneliness. We assessed social isolation in terms of contact with family and friends and participation in civic organizations in 6,500 men and women aged 52 and older who took part in the English Longitudinal Study of Ageing in [2004][2005]. A standard questionnaire measure of loneliness was administered also. We monitored all-cause mortality up to March 2012 (mean follow-up 7.25 y) and analyzed results using Cox proportional hazards regression. We found that mortality was higher among more socially isolated and more lonely participants. However, after adjusting statistically for demographic factors and baseline health, social isolation remained significantly associated with mortality (hazard ratio 1.26, 95% confidence interval, 1.08-1.48 for the top quintile of isolation), but loneliness did not (hazard ratio 0.92, 95% confidence interval, 0.78-1.09). The association of social isolation with mortality was unchanged when loneliness was included in the model. Both social isolation and loneliness were associated with increased mortality. However, the effect of loneliness was not independent of demographic characteristics or health problems and did not contribute to the risk associated with social isolation. Although both isolation and loneliness impair quality of life and well-being, efforts to reduce isolation are likely to be more relevant to mortality.

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“…36 Studies in chronically stressed populations and those who have experienced overwhelming stress reported lower-than-normal levels. 37,38 Our data suggest that, for the women, the HADS anxiety scale reflected a more chronic state of anxiety (statistically significant negative correlation [P < 0.05]; as the HADS anxiety score increased, the salivary cortisol level decreased) compared with the men.…”

Section: Discussionmentioning

confidence: 99%

Gender as a determinant of responses to a self-screening questionnaire on anxiety and depression by patients with coronary artery disease

2009

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Social Isolation and Stress-related Cardiovascular, Lipid, and Cortisol Responses

Abstract: The impact of social isolation on cardiovascular disease risk may be mediated through stress-related dysregulation of cardiovascular, metabolic, and neuroendocrine processes.

Cited by 214 publications

References 58 publications

Altered ADAR1 in mice affected by social isolation stress-induced cognitive deficits

Altered ADAR1 in mice affected by social isolation stress-induced cognitive deficits

Social isolation, loneliness, and all-cause mortality in older men and women

Gender as a determinant of responses to a self-screening questionnaire on anxiety and depression by patients with coronary artery disease

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