Abstract:Social isolation and feelings of loneliness are related to higher mortality and morbidity. Evidence from studies conducted during space missions, in space analogs, and during the COVID-19 pandemic underline the possible role of the autonomic nervous system in mediating this relation. Indeed, the activation of the sympathetic branch of the autonomic nervous system enhances the cardiovascular response and activates the transcription of pro-inflammatory genes, which leads to a stimulation of inflammatory activati… Show more
“…Healthcare workers, who were under significant pressure due to the pandemic and had more dysregulation of personal and social rhythms, were found to be at greater risk for burnout syndrome and mood disorders [34][35][36][37]. The dysregulation of social rhythms negatively impacts the course and outcomes of chronic diseases and immune responses [38,39].…”
Clarifying the mechanisms by which circadian rhythms regulate biology is a central issue in directing life choices in the immediate future and presents an interesting challenge for current scientific research [...]
“…Healthcare workers, who were under significant pressure due to the pandemic and had more dysregulation of personal and social rhythms, were found to be at greater risk for burnout syndrome and mood disorders [34][35][36][37]. The dysregulation of social rhythms negatively impacts the course and outcomes of chronic diseases and immune responses [38,39].…”
Clarifying the mechanisms by which circadian rhythms regulate biology is a central issue in directing life choices in the immediate future and presents an interesting challenge for current scientific research [...]
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