Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice

Kim, Do Gyeong; Gonzales, Edson Luck; Kim, Seonmin; Kim, Yujeong; Adil, Keremkleroo Jym; Jeon, Se Jin; Cho, Kyu Suk; Kwon, Kyoung Ja; Shin, Chan Young

doi:10.5607/en.2019.28.2.247

Cited by 35 publications

(32 citation statements)

References 40 publications

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“…A battery of social interaction behaviors, such as crawling under other mice, frontward running, mounting, probing, sniffing, and grooming, were recorded for 5 min. 40 …”

Section: Methodsmentioning

confidence: 99%

6-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism

et al. 2021

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Anxiety and depression are among the major traumatic brain injury-induced psychiatric disorders in survivors. The present study was undertaken to investigate the beneficial effects of 6-Shogaol against depression-like behavior and anxiety, induced by traumatic brain injury (TBI), in mice. The mice were administered either fluoxetine, vehicle, or three different doses (10, 20 and 30 mg/kg/day, i.p.) of 6-Shogaol after 10 days of impact-accelerated TBI. The treatment was continued for 14 consecutive days. Elevated plus maze test, marble burying test, staircase test, and social interaction test were employed to investigate the effect of 6-Shogaol on anxiety-like behavior. The impact of treatment on depression-like behavior was assessed using hyper-emotionality behavior or open-field exploration test. The expressions of brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and malondialdehyde (MDA) levels in brain tissue and brain water were measured to elucidate possible mechanisms involved. 6-Shogaol treatment (higher dose) was able to attenuate anxiety/depression-like behaviors in mice with TBI. 6-Shogaol treatment also altered MDA formation and expressions of TNF-α and IL-1β that act as major inflammation-inducing cytokines in brain tissue. Additionally, brain BDNF levels were also affected by 6-Shogaol treatment. Although the lower dose of 6-Shogaol was able to rectify inflammation and BDNF expression in brain tissue, it was unable to improve anxiety/depression-like behaviors. 6-Shogaol treatment produced beneficial effects for TBI-induced anxiety/depression-like behaviors in mice, which could be attributed to the reduction of lipid peroxidation, inflammation, and enhanced BDNF expression.

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“…A battery of social interaction behaviors, such as crawling under other mice, frontward running, mounting, probing, sniffing, and grooming, were recorded for 5 min. 40 …”

Section: Methodsmentioning

confidence: 99%

6-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism

et al. 2021

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“…is blocked. The social preference test (conducted mostly in rodents; Kim et al, 2019a) measures the relative time a test animal spends approaching and investigating two social targets or a social and non-social target under a cup. This assesses the animal's internal readiness to engage with the stimulus, commonly referred to as social interest.…”

Section: Investigation Phasementioning

confidence: 99%

Neural circuits of social behaviors: Innate yet flexible

Wei

Talwar

Lin

2021

Neuron

118

103

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“…[ 64,85] Novel object approaching Zebrafish is fearful of the novel object and spends time near the wall of the arena (thigmotaxis).…”

Section: Indicators Of Anxiety-and Depressive-like Behavior: Reduced Social Interactionsmentioning

confidence: 99%

Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

Lachowicz

Niedziałek

Rostkowska³

et al. 2021

Life

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Depression is a serious mental disease that, according to statistics, affects 320 million people worldwide. Additionally, a current situation related to the COVID-19 pandemic has led to a significant deterioration of mental health in people around the world. So far, rodents have been treated as basic animal models used in studies on this disease, but in recent years, Danio rerio has emerged as a new organism that might serve well in preclinical experiments. Zebrafish have a lot of advantages, such as a quick reproductive cycle, transparent body during the early developmental stages, high genetic and physiological homology to humans, and low costs of maintenance. Here, we discuss the potential of the zebrafish model to be used in behavioral studies focused on testing agents with antidepressant potential.

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Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice

Cited by 35 publications

References 40 publications

6-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism

6-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism

Neural circuits of social behaviors: Innate yet flexible

Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential

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