This article is devoted to an assessment of the influence of infrastructure on social and economic development of the Russian regions. Various approaches to the treatment of concept of infrastructure are considered, especially chosen are industrial and functional approaches. According to the first of them, the infrastructure is considered as the set of the industries and kinds of activity that are providing activity conditions on an area of the country or the region. According to the second, it is considered as the set of the certain functions that are directed to the solution of organizational, economic and social challenges. Types of infrastructuresocial, economic and financial-are theorized. Authors formed the list of the indicators representing financial, social, economic infrastructures and the real sector of economy. The relation has been investigated between the elements of infrastructures and the social and economic development of the Russian regions. The results of the econometric analysis were defined the elements which influenced the social and economic development of the regions. There are investments into fixed capital, resources mining, public catering, deposits of the population, the number of hospital beds. Five defined groups of the regions with typical problems were identified in the cluster analysis.