Social information processing following resection of the insular cortex

Boucher, Olivier; Rouleau, Isabelle; Lassonde, Maryse; Leporé, Franco; Bouthillier, Alain; Nguyen, Dang Khoa

doi:10.1016/j.neuropsychologia.2015.03.008

Cited by 79 publications

(55 citation statements)

References 68 publications

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“…For ER, previous neuroimaging studies have revealed that the insula is involved in the perception of emotions (Bernhardt & Singer, 2012;Jabbi, Swart, & Keysers, 2007;Lamm & Singer, 2010). Subsequent research from patients for whom the insula was removed found that the patients' ability to recognize facial expressions of fear, happiness, and surprise was impaired (Boucher et al, 2015). Consistent with previous studies, we obtained data in patients with an insular glioma and corrected defects of previous studies.…”

Section: Evaluation Of Aesupporting

confidence: 89%

“…For example, Fan et al (2011) and Gonzalez-Liencres et al (2013) revealed that CE is also supported by activation of the insula. We also found evidence that patients with insular resection had lower scores in the PT subscale, which denoted the tendency to take the mental perspective of others and composed of items that are associated with the social competence, other-oriented sensitivity and CE (Boucher et al, 2015;Shamay-Tsoory et al, 2009). To date, these results do not yet provide causal evidence for the role of the insula in CE.…”

Section: Assessment Of Cementioning

confidence: 58%

“…In addition, we included a group of lesion controls to control the influence of intracranial hypertension and mental change that was caused by the disease. Boucher et al (2015) suggested that insular lesion patients had an impaired ability to recognize facial expressions and had low scores on perspective taking. Yet, this study could not exclude the possibility that performance on these tasks was already impaired prior to surgery as a result of the long-term effect of epilepsy on brain function (Realmuto et al, 2015).…”

Section: The Present Studymentioning

confidence: 99%

“…Calder et al (2000) described a case wherein a patient presented with an impairment in the experience and recognition of the emotion of disgust following a left hemisphere infarction that involved the insula and the basal ganglia . Boucher et al (2015) presented a study that examined social information processing in patients for whom the insula was partially or completely removed following epilepsy surgery. In doing so, they found the patients were impaired in recognizing facial expressions (Boucher et al, 2015).…”

mentioning

confidence: 99%

“…Boucher et al (2015) presented a study that examined social information processing in patients for whom the insula was partially or completely removed following epilepsy surgery. In doing so, they found the patients were impaired in recognizing facial expressions (Boucher et al, 2015). Leigh et al (2013) suggested that the impairment of AE is associated with empathy network infarcts in patients with acute right hemisphere ischemic stroke, particularly in the temporal pole and anterior insular infarcts .…”

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confidence: 99%

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Multidimensional assessment of empathic abilities in patients with insular glioma

Chen

Wang

et al. 2016

Cogn Affect Behav Neurosci

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Recent studies have provided evidence that there are two possible systems for empathy: affective empathy (AE) and cognitive empathy (CE). Neuroimaging paradigms have proven that the insular cortex is involved in empathy processing, particularly in AE. However, these observations do not provide causal evidence for the role of the insula in empathy. Although impairments in empathy have been described following insular damage in a few case studies, it is not clear whether insular cortex is involved in CE and whether these two systems are impaired independently or laterally in patients with insular gliomas. In this study, we assessed 17 patients with an insular glioma, 17 patients with a noninsular glioma, and 30 healthy controls using a method that combined a self-report empathy questionnaire with the emotion recognition task, assessment of empathy for others' pain, and the emotional perspective-taking paradigm. We found that patients with an insular glioma had lower scores for empathic concern and perspective taking than did either healthy controls or lesion controls. The patients' abilities to recognize facial emotions, perceive others' pain, and understand the emotional perspectives of others were also significantly impaired. Furthermore, we did not observe a laterality effect on either AE or CE among those with insular lesions. These findings revealed that both AE and CE are impaired in patients with an insular glioma and that the insular cortex may be a central neuroanatomical structure in both the AE and CE systems.

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Section: Evaluation Of Aesupporting

confidence: 89%

Section: Assessment Of Cementioning

confidence: 58%

Section: The Present Studymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Multidimensional assessment of empathic abilities in patients with insular glioma

Chen

Wang

et al. 2016

Cogn Affect Behav Neurosci

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Social Cognition in Parkinson's Disease after Focused Ultrasound Subthalamotomy: A Controlled Study

Guida,

Martínez‐Fernández,

Máñez‐Miró

et al. 2024

Movement Disorders

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Social cognition (SC) encompasses a set of cognitive functions that enable individuals to understand and respond appropriately to social interactions. Although focused ultrasound subthalamotomy (FUS‐STN) effectively treats Parkinson's disease (PD) clinical motor features, its impact and safety on cognitive‐behavioral interactions/interpersonal awareness are unknown. This study investigated the effects of unilateral FUS‐STN on facial emotion recognition (FER) and affective and cognitive theory of mind (ToM) in PD patients from a randomized sham‐controlled trial (NCT03454425). Subjects performed SC evaluation before and 4 months after the procedure while still under blind assessment conditions. The SC assessment included the Karolinska Directed Emotional Faces task for FER, the Reading the Mind in the Eyes (RME) test for affective ToM, and The Theory of Mind Picture Stories Task (ToM PST) (order, questions, and total score) for cognitive ToM. The active treatment group showed anecdotal‐to‐moderate evidence of no worsening in SC after FUS‐STN. Anecdotal evidence for an improvement was recognized in the SC score changes, from baseline to post‐treatment, for the active treatment group compared with sham for the RME, ToM PST order, ToM PST total, FER total, and recognition of fear, disgust, and anger. This study provides the first evidence that unilateral FUS‐STN does not impair social cognitive abilities, indicating that it can be considered a safe treatment approach for this domain in PD patients. Furthermore, the results suggest FUS‐STN may even lead to some improvement in social cognitive outcomes, which should be considered as a preliminary finding requiring further investigation with larger samples sizes. © 2024 International Parkinson and Movement Disorder Society.

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Role of the Insular Cortex in Emotional Awareness

Jumah

2018

Island of Reil (Insula) in the Human Brain

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Social information processing following resection of the insular cortex

Cited by 79 publications

References 68 publications

Multidimensional assessment of empathic abilities in patients with insular glioma

Multidimensional assessment of empathic abilities in patients with insular glioma

Social Cognition in Parkinson's Disease after Focused Ultrasound Subthalamotomy: A Controlled Study

Role of the Insular Cortex in Emotional Awareness

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