Background Hypertension, a major risk factor of many sever chronic diseases and leading cause of global disease burden, is reported associated with exposure to PM 2.5. China's high PM 2.5 pollution level has become a major public health issue. However, existing studies from China on the effect of PM 2.5 exposure on hypertension have got inconsistent results with very limited investigation into the multi-ethnic people. This study adds multi-ethnic evidence from Sichuan Province, southwestern China, and assesses ethnic differences of PM 2.5 exposure effect on hypertension. Methods We pooled large cross-sectional data from two surveys conducted in Sichuan province in 2013 and 2018 to exam the effect of long-term exposure to PM 2.5 on prevalence of hypertension in adults aged 30 years old and above. Community-speci ed annual PM 2.5 concentration was estimated using satellite data. Logistic regression was applied to examine the association between long-term exposure to PM 2.5 and hypertension prevalence in the whole population, speci c ethnic populations and population (including Han and ethnic minority people) living in same areas. Results 31462 participants with an average age of 56 years old were included. The average exposure concentration was 32.8 µg/m 3. The proportions of the Han, the Tibetan, the Yi, and other ethnic people were 89.2%, 7.3%, 3.2%, and 0.3%, respectively. The adjusted odds ratio (OR) was 1.08 (95% CI, 1.04-1.12) for a 10 µg/m 3 PM 2.5 concentration increment for the whole population. The adjusted ORs for the Han, the Tibetan, and the Yi were 1.08 (95% CI, 1.04-1.12), 0.03 (95% CI, 0.00-0.27), and 1.75 (95% CI, 1.28-2.38) for a 10 µg/m 3 PM 2.5 concentration increment, respectively. Strati cation analysis found stronger associations in participants with chronic diseases and Yi minority population. Conclusion Long-term exposure to PM 2.5 may increase the risk of hypertension prevalence in Chinese multi-ethnic adults. Stronger associations were found in people with chronic disease and Yi minority group.