Social functioning and brain imaging in individuals at clinical high-risk for psychosis: A systematic review

Metzak, Paul D.; Farris, Megan S.; Placsko, Thea; Braun, Amy; Bonneville, Dominique; Brummitt, Kali; Chu, Monica W.; Addington, Jean

doi:10.1016/j.schres.2021.04.013

Cited by 6 publications

(2 citation statements)

References 53 publications

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“…A quality assessment of the included studies was conducted using a modified checklist similar to a previously published review. 10 The categories scored in the quality assessment checklist were: (1) role of the funding source in data interpretation and analysis, (2) sample size, (3) clearly reported inclusion criteria, (4) exclusion criteria, (5) reported sex distribution, (6) reported race/ethnic origin distribution, (7) reported IQ, educational level, and (8) reported dropout rate. Each item in the checklist was assigned a score of 0–2, with 0 being the lowest quality and 2 being the highest quality.…”

Section: Methodsmentioning

confidence: 99%

Patient-Reported Outcome Measures in Clinical High Risk for Psychosis: A Systematic Review

Addington

Chao

Braun

et al. 2023

Schizophrenia Bulletin Open

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A key issue in both research and clinical work with youth at clinical high risk (CHR) of psychosis is that there are clearly heterogenous clinical outcomes in addition to the development of psychosis. Thus, it is important to capture the psychopathologic outcomes of the CHR group and develop a core outcomes assessment set that may help in dissecting the heterogeneity and aid progress towards new treatments. In assessing psychopathology and often poor social and role functioning, we may be missing the important perspectives of the CHR individuals themselves. It is important to consider the perspectives of youth at CHR by using Patient Reported Outcome Measures (PROMs). This systematic review of PROMs in CHR was conducted based on a comprehensive search of several databases and followed PRISMA guidelines. Sixty-four publications were included in the review examining PROMs for symptoms, functioning, quality of life, self-perceptions, stress and resilience. Typically, PROMs were not the primary focus of the studies reviewed. The PROMs summarized here fit with results published elsewhere in the literature based on interviewer measures. However, very few of the measures used were validated for CHR or for youth. There are several recommendations for determining a core set of PROMs for use with CHR.

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Section: Methodsmentioning

confidence: 99%

Patient-Reported Outcome Measures in Clinical High Risk for Psychosis: A Systematic Review

Addington

Chao

Braun

et al. 2023

Schizophrenia Bulletin Open

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“…In patients with psychosis, disruptions in social functioning are a fundamental characteristic of the disease [ 1 ]. One of the factors that is studied in relation to social functioning is substance use [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship between substance use and self-reported aspects of social functioning in patients with a psychotic disorder

van der Heijden,

Kikkert,

de Haan

et al. 2024

Eur. Psychiatr.

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Background. In patients with a psychotic disorder, rates of substance use (tobacco, cannabis, and alcohol) are higher compared to the general population. However, little is known about associations between substance use and self-reported aspects of social functioning in patients with a psychotic disorder. Methods. In this cross-sectional study of 281 community-dwelling patients with a psychotic disorder, linear regression models were used to assess associations between substance use (tobacco, cannabis, or alcohol) and self-reported aspects of social functioning (perceived social support, stigmatization, social participation, or loneliness) adjusting for confounders (age, gender, and severity of psychopathology). Results. Compared to nonsmokers, both intermediate and heavy smokers reported lower scores on loneliness (E = À0.580, SE = 0.258, p = 0.025 and E = À0.547, SE = 0,272, p = 0.046, respectively). Daily cannabis users reported less social participation deficits than non-cannabis users (E = À0.348, SE = 0.145, p = 0.017). Problematic alcohol use was associated with more perceived social support compared to non-alcohol use (E = 3.152, SE = 1.102, p = 0.005). Polysubstance users reported less loneliness compared to no users (E = À0.569, SE = 0.287, p = 0.049). Conclusions. Substance use in patients with psychosis is associated with more favorable scores on various self-reported aspects of social functioning.

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Relation between white matter integrity, perfusion, and processing speed in early-stage schizophrenia

Chen

Mihaljević

Hou

et al. 2023

Journal of Psychiatric Research

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Social functioning and brain imaging in individuals at clinical high-risk for psychosis: A systematic review

Cited by 6 publications

References 53 publications

Patient-Reported Outcome Measures in Clinical High Risk for Psychosis: A Systematic Review

Patient-Reported Outcome Measures in Clinical High Risk for Psychosis: A Systematic Review

The relationship between substance use and self-reported aspects of social functioning in patients with a psychotic disorder

Relation between white matter integrity, perfusion, and processing speed in early-stage schizophrenia

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