Social factors affecting emotionality and resistance to disease in animals: II. Susceptibility to gastric ulceration as a function of interruptions in social interactions and the time at which they occur.

Ader, Robert; Beels, C. Christian; Tatum, Ronald

doi:10.1037/h0048003

Cited by 19 publications

(1 citation statement)

References 2 publications

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“…Single housing, linked to the development of an “isolation syndrome” (Ader et al 1960; Stern et al 1960; Hatch et al 1965) is not the source of the anxiety-related behaviors observed in the DEX and HC –treated animals. Anxiety –related behaviors were detected in DEX and HC –treated adult animals irrespective of the single housing or the grouped housing condition that was imposed from adolescence to adulthood.…”

Section: Discussionmentioning

confidence: 99%

Regulation of corticoid and serotonin receptor brain system following early life exposure of glucocorticoids: Long term implications for the neurobiology of mood

Vázquez

Neal

Patel

et al. 2012

Psychoneuroendocrinology

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Potent glucocorticoids (GC) administered early in life has improved premature infant survival dramatically. However, these agents may increase the risk for physical, neurological and behavior alterations. Anxiety, depression and attention difficulties are commonly described in adolescent and young adult survivors of prematurity. In the present study we administered vehicle, dexamethasone, or hydrocortisone to Sprague-Dawley rat pups on postnatal days 5 and 6, mimicking a short term clinical protocol commonly used in human infants. Two systems that are implicated in the regulation of stress and behavior were assessed: the limbic-hypothalamic-pituitary-adrenal axis [LHPA, glucocorticoid and mineralocorticoid receptors within] and the Serotonin (5-HT) system. We found that as adults, male Sprague-Dawley pups treated with GC showed agent specific altered growth, anxiety-related behavior, changes in corticoid response to novelty and gene expression changes within LHPA and 5-HT–related circuitry. The data suggest that prolonged GC-receptor stimulation during the early neonatal period can contribute to the development of individual differences in stress response and anxiety-related behavior later in life.

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Section: Discussionmentioning

confidence: 99%

Regulation of corticoid and serotonin receptor brain system following early life exposure of glucocorticoids: Long term implications for the neurobiology of mood

Vázquez

Neal

Patel

et al. 2012

Psychoneuroendocrinology

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show abstract

Significance of gastric secretory changes in the pathogenesis of stress ulcers

1975

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Analyses of gastric juice withdrawn 3 hours after the pylorus was ligated and of plasma corticosterone and blood glucose after animals were exposed to rotational stress revealed that gastric secretion was highest in controls, intermediate in stressed rats that developed ulcers, and lowest in stressed rats that did not develop ulcers. Neither high nor low gastric secretion correlated with stress-ulcer formation. When initial mucosal ischemia and secretory inhibition, which occurred in all stressed rats, were considered, those that developed ulcers manifested gastric hypersecretion when compared with those that did not develop ulcers. The pathogenetic significance of gastric hypersecretion in stress-ulcer formation is discussed and correlated with mucosal microvascular changes during stress. Mean plasma corticosterone was highest in stressed rats that developed ulcers, next highest in stressed rats that did not develop ulcers, and lowest in control rats. Compared with normal rats, mean blood glucose was lowest in stressed rats and highest in controls. Hypoglycemic changes were more marked in stressed rats that developed ulcers than in stressed rats that did not develop ulcers.

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Sex differences in emotional behaviour in mammals including man: Endocrine bases

Gray

1971

Acta Psychologica

252

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Social factors affecting emotionality and resistance to disease in animals: II. Susceptibility to gastric ulceration as a function of interruptions in social interactions and the time at which they occur.

Cited by 19 publications

References 2 publications

Regulation of corticoid and serotonin receptor brain system following early life exposure of glucocorticoids: Long term implications for the neurobiology of mood

Regulation of corticoid and serotonin receptor brain system following early life exposure of glucocorticoids: Long term implications for the neurobiology of mood

Significance of gastric secretory changes in the pathogenesis of stress ulcers

Sex differences in emotional behaviour in mammals including man: Endocrine bases

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