Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization

Ahmed, Serge H.; Stinus, L.; Moal, Michel Le; Cador, Martine

doi:10.1007/bf02245106

Cited by 76 publications

(51 citation statements)

References 60 publications

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“…The behavioural, endocrine or neurochemical consequences of IH have been less studied, and seem generally to be less profound than those of IR. Rats isolated in adulthood demonstrate spontaneous hyperactivity in open fields, increased locomotor response to systemic amphetamine administration, and increased timidity towards novel environments (Ahmed et al 1995). In addition, IH has been reported to impair water maze learning (Wade and Maier 1986).…”

Section: Social Isolationsupporting

confidence: 44%

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

2001

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Rationale: In schizophrenia research, the study of animal models has received considerable attention in the past 20 years. The value of animal models in preclinical research is widely recognised, largely because they can provide precious knowledge regarding the neurobiology of schizophrenia and can also be used for developing antipsychotic drugs. Prepulse inhibition (PPI; reduction in startle reflex induced by a prestimulus) is impaired in schizophrenic patients, a finding that has been associated with a loss of sensorimotor gating abilities. In rats, the schizophrenic-like PPI deficit can be induced by pharmacological or surgical manipulations targeting mainly the cortico-meso-limbic circuitry. Objectives: The literature was critically reviewed in an effort to determine the robustness and the relevance for schizophrenia of another category of animal models, based purely on manipulations of the social environment, that encompasses the neurodevelopmental hypothesis of schizophrenia. Specifically, we focused our attention on the long-term effects of such environmental models on sensorimotor gating processes as assessed in the PPI paradigm, with an attempt to evaluate their face, predictive and construct validity. Results: Our review of the literature leads to the conclusion that social deprivation performed directly after weaning (~21 days of age) is more likely to be a relevant model for PPI impairments in schizophrenia than pre-weaning manipulations. Conclusions: Although the robustness of such environmental models requires further study, these animal models offer the advantage of avoiding invasive manipulations, which allows for a variety of anatomical, electrophysiological, neuroendocrine or neurochemical investigations in the absence of confounding pharmacological or surgical effects.

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Section: Social Isolationsupporting

confidence: 44%

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

2001

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“…Notably, long-term isolation modifies dopaminergic transmission (Ahmed et al, 1995;Gendreau et al, 2000), and corticolimbic release of DA is altered both before and following aggressive encounters (Isovich et al, 2001;Ferrari et al, 2003). It is, thus, of interest that S32504 inhibited aggressive behavior, an effect mimicked by ropinirole and other D 2 /D 3 receptor agonists (Gendreau et al, 2000).…”

supporting

confidence: 42%

S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole

Millan¹,

Brocco²,

Papp³

et al. 2004

J Pharmacol Exp Ther

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In forced-swim tests in mice and rats, the novel D 3 /D 2 receptor agonist S32504 [(ϩ)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth[1,2-b]-1,4-oxazine] dose-dependently (0.04 -2.5 mg/kg) and stereospecifically suppressed immobility compared with its enantiomer S32601 [(Ϫ)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth-[1,2-b]-1,4-oxazine]. Ropinirole was less potent than S32504 in this procedure, and it was likewise less potent than S32504 (0.04 -2.5 mg/kg) in attenuating motor-suppressant properties of the ␣ 2 -adrenoceptor agonist S18616 [(S)-spiro[(1-oxa-2-amino-3-azacyclopent-2-ene)-4,2Ј-(1Ј,2Ј,3Ј,4Ј-tetrahydronaphthalene)]]. In a learned helplessness paradigm, S32504 (0.08 -2.5 mg/kg) suppressed escape failures. Furthermore, in a chronic mild stress model of anhedonia, S32504 (0.16 -2.5 mg/kg) rapidly restored the suppression of sucrose consumption. S32504 inhibited marble-burying behavior in mice (0.04 -0.16 mg/kg) and aggressive behavior in isolated mice (0.04 -2.5 mg/kg): only higher doses of ropinirole mimicked these actions of S32504. In tests of anxiolytic activity, S32504 was more potent (0.0025-0.16 mg/kg) than ropinirole in suppressing fear-induced ultrasonic vocalizations, and S32601 was inactive. Furthermore, in contrast to ropinirole, S32504 modestly enhanced punished responses in a Vogel conflict procedure and increased open-arm entries in a plus-maze. At doses active in the above-described procedures, S32504 did not elicit hyperlocomotion. In the forced-swim, marble-burying, and ultrasonic vocalization models, actions of S32504 were Although the most familiar feature of Parkinson's disease is a disruption of motor function, it is accompanied by mood, sensory, and cognitive symptoms (Giladi et al., 2000). These often anticipate onset of frank motor dysfunction and are, in general, poorly treated by the prototypical antiparkinsonian agent L-3,4-dihydroxyphenylalanine (Giladi et al., 2000;Rascol et al., 2003). A perturbation of adrenergic, serotonergic, and cholinergic transmission likely contributes to these interrelated features of Parkinson's disease, but the principal underlying deficit is a degeneration of nigrostriatal dopaminergic projections together with a (less pronounced) dysfunction of mesolimbic and mesocortical dopaminergic pathways (Rascol et al., 2003). Interestingly, as indicated by the following observations, a disruption of dopaminergic transmission is implicated in the depressed mood displayed both by ParArticle, publication date, and citation information can be found at

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“…Previous research has shown that social or enriched housing attenuates the development of amphetamine sensitization (Ahmed, Stimus, Le Moal, & Candor, 1995;Bardo et al, 1995), but it is unclear whether the results generalize to cocaine or natural rewards. Environmental enrichment also appears to reduce the propensity to self-administer drugs and work for nondrug reinforcers.…”

mentioning

confidence: 43%

Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Klein

Gehrke

Green

et al. 2007

Learning and Motivation

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The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have crosssensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.

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Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization

Cited by 76 publications

References 60 publications

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole

Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

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Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization

Cited by 76 publications

References 60 publications

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review

S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole

Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

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S32504, a Novel Naphtoxazine Agonist at Dopamine D₃/D₂ Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole