Social cohesion and loneliness are associated with the antibody response to COVID-19 vaccination

Gallagher, Stephen; Howard, Siobhán; Orla, T. Muldoon; Anna, C. Whittaker

doi:10.1016/j.bbi.2022.04.017

Cited by 22 publications

(12 citation statements)

References 65 publications

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“…These three genes are linked to the severity of COVID-19 infection [ 43 , 44 , 66 ]. Others have reported that social isolation impaired the antibody response to the COVID-19 vaccine [ 67 ]. Possible effectiveness of Asian herbal mixtures to reduce the symptoms of COVID-19 has been assessed in many studies, and one such mixture (NRICM101) is used in Taiwan for the clinical treatment of COVID-19 [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland

Andrade

Jin

Clarke

et al. 2023

Cells

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Although multifactorial in origin, one of the most impactful consequences of social isolation is an increase in breast cancer mortality. How this happens is unknown, but many studies have shown that social isolation increases circulating inflammatory cytokines and impairs mitochondrial metabolism. Using a preclinical Sprague Dawley rat model of estrogen receptor-positive breast cancer, we investigated whether social isolation impairs the response to tamoxifen therapy and increases the risk of tumors emerging from dormancy, and thus their recurrence. We also studied which signaling pathways in the mammary glands may be affected by social isolation in tamoxifen treated rats, and whether an anti-inflammatory herbal mixture blocks the effects of social isolation. Social isolation increased the risk of dormant mammary tumor recurrence after tamoxifen therapy. The elevated recurrence risk was associated with changes in multiple signaling pathways including an upregulation of IL6/JAK/STAT3 signaling in the mammary glands and tumors and suppression of the mitochondrial oxidative phosphorylation (OXPHOS) pathway. In addition, social isolation increased the expression of receptor for advanced glycation end-products (RAGE), consistent with impaired insulin sensitivity and weight gain linked to social isolation. In socially isolated animals, the herbal product inhibited IL6/JAK/STAT3 signaling, upregulated OXPHOS signaling, suppressed the expression of RAGE ligands S100a8 and S100a9, and prevented the increase in recurrence of dormant mammary tumors. Increased breast cancer mortality among socially isolated survivors may be most effectively prevented by focusing on the period following the completion of hormone therapy using interventions that simultaneously target several different pathways including inflammatory and mitochondrial metabolism pathways.

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Section: Discussionmentioning

confidence: 99%

Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland

Andrade

Jin

Clarke

et al. 2023

Cells

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“…Poor social connection is linked to other health outcomes, including newly and previously diagnosed type 2 diabetes (Brinkhues et al, 2017). Social connectedness also influences the susceptibility to viruses—independent of baseline immunity (virus-specific antibody), demographics, and health practices (Cohen, 2020; Cohen et al, 2003)—and the ability to mount an effective immune response to a vaccine (Gallagher et al, 2022; Madison et al, 2021).…”

Section: How Strong Is the Evidence?mentioning

confidence: 99%

National Health Guidelines for Social Connection: What Is the Evidence in Support and What Might the Guidelines Say?

Holt‐Lunstad

2023

Policy Insights from the Behavioral and Brain Sciences

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National health guidelines provide policy makers and the public with recommendations for various behavioral factors known to promote health and reduce disease risk, such as diet and physical activity. Given public health concerns about social isolation, loneliness, and other forms of lacking social connection, the evidence supports establishing national health guidelines for “social connection.” The aggregate body of scientific evidence demonstrates social connection protects health and reduces health risks, pointing to clear relevance for public health. Taken together with national trends suggesting greater social disconnection, there is a compelling case for national preventative efforts. This article summarizes evidence on the health relevance of social connections, potential opportunities, and challenges in establishing and implementing guidelines, the process of establishing guidelines, and provides illustrative evidence-based examples of potential recommendations.

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“…One of the few published studies in this area is of 676 adults from an ongoing UK-based longitudinal study who had antibodies measured following a single dose of the COVID-19 vaccine. The authors found that less social cohesion was associated with lower antibody responses, and this was in part mediated by feelings of loneliness (Gallagher et al, 2022). However, they did not examine whether effects differed by vaccine type.…”

Section: Psychosocial Factors and Covid-19mentioning

confidence: 99%

Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health

Jones

Ayling

Wiley

et al. 2023

Policy Insights from the Behavioral and Brain Sciences

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Psychosocial factors are related to immune, viral, and vaccination outcomes. Yet, this knowledge has been poorly represented in public health initiatives during the COVID-19 pandemic. This review provides an overview of biopsychosocial links relevant to COVID-19 outcomes by describing seminal evidence about these associations known prepandemic as well as contemporary research conducted during the pandemic. This focuses on the negative impact of the pandemic on psychosocial health and how this in turn has likely consequences for critically relevant viral and vaccination outcomes. We end by looking forward, highlighting the potential of psychosocial interventions that could be leveraged to support all people in navigating a postpandemic world and how a biopsychosocial approach to health could be incorporated into public health responses to future pandemics.

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Social cohesion and loneliness are associated with the antibody response to COVID-19 vaccination

Cited by 22 publications

References 65 publications

Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland

Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland

National Health Guidelines for Social Connection: What Is the Evidence in Support and What Might the Guidelines Say?

Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health

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