Social cognition in patients at ultra-high risk for psychosis: What is the relation to social skills and functioning?

Glenthøj, Birte; Fagerlund, Birgitte; Hjorthøj, Carsten; Jepsen, Jens Richardt Møllegaard; Bak, Nikolaj; Kristensen, Tina Dam; Wenneberg, Christina; Krakauer, Kristine; Roberts, David L.; Nordentoft, Merete

doi:10.1016/j.scog.2016.06.004

Cited by 52 publications

(52 citation statements)

References 53 publications

(66 reference statements)

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“…Current approaches did not produce significantly larger effects on social functioning than control conditions Van der Gaag et al, 2013). Thus, novel interventions are needed to directly target factors modulating social functioning, such as social cognition (Cotter et al, 2017;Glenthøj et al, 2016;Schmidt, Mueller, & Roder, 2011).…”

Section: Need For Integrated Preventive Psychological Interventionsmentioning

confidence: 92%

“…Current approaches did not produce significantly larger effects on social functioning than control conditions (Schmidt et al, ; Van der Gaag et al, ). Thus, novel interventions are needed to directly target factors modulating social functioning, such as social cognition (Cotter et al, ; Glenthøj et al, ; Schmidt, Mueller, & Roder, ). Social cognition as the mental operations underlying social interactions comprises the following domains: social and emotional perception, Theory of Mind and social attribution styles (Green et al, ; Pinkham, Penn, Green, & Harvey, ).…”

Section: Introductionmentioning

confidence: 99%

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Multimodal prevention of first psychotic episode through N‐acetyl‐l‐cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo‐controlled, parallel‐group trial

Schmidt

Hurlemann

Schultz

et al. 2019

Early Intervention Psych

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Aim Meta‐analyses indicate positive effects of both antipsychotic and cognitive‐behavioural interventions in subjects clinically at high risk (CHR) for psychosis in terms of a delay or prevention of psychotic disorders. However, these effects have been limited regarding social functioning and the relative efficacy of both types of interventions remains unclear. Furthermore, neuroprotective substances seem to be a promising alternative agent in psychosis‐prevention as they are associated with few and weak side‐effects. Methods In this multi‐centre randomized controlled trial (RCT), we investigate the effects of two interventions on transition to psychosis and social functioning: (a) an integrated preventive psychological intervention (IPPI) including stress‐/symptom‐management and social‐cognitive remediation; (b) N‐acetyl‐l‐cysteine (NAC) as a pharmacological intervention with glutamatergic, neuroprotective and anti‐inflammatory capabilities. Results This is a double‐blind, placebo‐controlled RCT with regard to NAC and a single‐blind RCT with regard to IPPI using a 2 × 2‐factorial design to investigate the individual and combined preventive effects of both interventions. To this aim, a total of 200 CHR subjects will be randomized stratified by site to one of four conditions: (a) IPPI and NAC; (b) IPPI and Placebo; (c) NAC and psychological stress management; (d) Placebo and psychological stress management. Interventions are delivered over 26 weeks with a follow‐up period of 12 months. Conclusion This paper reports on the rationale and protocol of an indicated prevention trial to detect the most effective and tolerable interventions with regard to transition to psychosis as well as improvements in social functioning, and to evaluate the synergistic effects of these interventions.

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Section: Need For Integrated Preventive Psychological Interventionsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Multimodal prevention of first psychotic episode through N‐acetyl‐l‐cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo‐controlled, parallel‐group trial

Schmidt

Hurlemann

Schultz

et al. 2019

Early Intervention Psych

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“…Speci c to the relationship between TASIT and SRS, a prior study did not nd a signi cant association between TASIT performance and SRS in 22q11DS (48) in line with our ndings. One study on adult CHR participants found a signi cant association between higher TASIT scores and lower self-reported SRS scores (50). Another study on adults ASD participants found a signi cant association between higher TASIT scores and higher self-reported SRS scores (86).…”

Section: Discussionmentioning

confidence: 99%

“…The original SRS administered to parents/caregivers of the FEP group was rescored using the updated norms for the revised version (SRS-2), both of which have the same items, so as to be consistent across all groups. The SRS was originally developed to quantify (dimensionally measured) social impairments within the context of the ASD phenotype, but has now been extended to many other clinical populations, including 22q11DS (20,48), CHR (21,49,50), and FEP (21,49). It has also been shown to index traits that are continuously distributed in the general population (51).…”

Section: Cognitive Measuresmentioning

confidence: 99%

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Jalal

Nair

Lin

et al. 2020

Preprint

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Abstract Background: 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior. Methods: We examined social cognition and intellectual functioning in 273 participants (mean age = 17.74+/-5.18% female = 44.3%): 50 with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 102 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2 nd edition (WASI-II) to assess intellectual functioning. Results: The 22q11DS group exhibited significantly lower social cognitive abilities compared to all other groups, even after controlling for intellectual functioning. Significant positive correlations were found between social cognition, as measured by the TASIT, and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. Conclusions: Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment.

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“…• Range: 1-5 • Higher scores indicate poorer functioning • Global measure derived from 3 to 6 role area scores: Occupational performance, social and leisure functioning, and physical well-being, relationship with family/marital/ children, domestic life, and financial situation 1.59 AE 0.33 (Weissman et al, 1978) CBT: 3.7 AE 0.85; SC: 3.5 AE 1.0 (Bechdolf et al, 2007) Social functioning scale (SFS) • Normalized to mean = 100 SD = 15 • Lower scores indicate poorer functioning • Global measure derived from 7 sub-scores: withdrawal/social engagement, interpersonal communication, independence-performance, independence competence, recreation, prosocial and employment/occupation 161.65 AE 20.23 125.29 AE 22.77 Social and occupational functioning assessments scale (SOFAS) (Glenthøj et al, 2016) 56.25 AE 10.02 (Glenthøj et al, 2016) Abbreviations: CBT, cognitive behavioural therapy; SC, supportive counselling.…”

Section: Other Interventionsmentioning

confidence: 99%

Interventions and social functioning in youth at risk of psychosis: A systematic review and meta‐analysis

Devoe

Farris

Townes

et al. 2018

Early Intervention Psych

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Social cognition in patients at ultra-high risk for psychosis: What is the relation to social skills and functioning?

Cited by 52 publications

References 53 publications

Multimodal prevention of first psychotic episode through N‐acetyl‐l‐cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo‐controlled, parallel‐group trial

Multimodal prevention of first psychotic episode through N‐acetyl‐l‐cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo‐controlled, parallel‐group trial

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Interventions and social functioning in youth at risk of psychosis: A systematic review and meta‐analysis

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