Social cognition in Multiple Sclerosis is associated to changes in brain connectivity: A resting-state fMRI study

Labbé, Tomás; Zurita, Mariana; Montalba, Cristián; Ciampi, Ethel; Cruz, Juan Pablo; Vásquez, Mónica; Uribe, Sergio; Crossley, Nicolás; Cárcamo, Claudia

doi:10.1016/j.msard.2020.102333

Cited by 13 publications

(13 citation statements)

References 27 publications

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“…Patients displayed increased FC between the left amygdala and several left cerebellar regions and the left temporal part of the brain, suggesting an involvement of this network in the adaptive compensatory mechanism responsible for the ToM task performances. In a previous study using rfMRI in patients performing normally in the Faux Pas, another test of ToM increased connectivity between the cerebellum and different parts of the brain correlated with Faux Pas performances (Labbe et al., 2020). The role of the cerebellum in SC has been demonstrated in many studies (Bonnet et al., 2010).…”

Section: Discussionmentioning

confidence: 96%

“…A few studies used functional MRI (fMRI) to investigate SC in MS (Bisecco et al, 2020; Golde et al., 2020; Jehna et al., 2011; Krause et al., 2009; Labbe et al., 2020; Passamonti et al., 2009). Only one used resting‐state fMRI (rfMRI) combined with RMET (Bisecco et al, 2020) and found no correlation between the functional connectivity (FC) and performances in the test (Bisecco et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Only one used resting‐state fMRI (rfMRI) combined with RMET (Bisecco et al, 2020) and found no correlation between the functional connectivity (FC) and performances in the test (Bisecco et al, 2020). However, the performances of patients with MS in the Faux Pas (FP) test, a test of affective and cognitive ToM, were correlated with FC between the right amygdala and the left inferior occipital and visual lateral cortices and with FC between the left cerebellum, the right occipital and visual lateral cortices, and the lingual gyrus (Labbe et al., 2020). None of the task‐based fMRI (tfMRI) studies regarding SC in MS focused on ToM (Jehna et al., 2011; Krause et al., 2009; Passamonti et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

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Amygdala network reorganization mediates the theory of mind performances in multiple sclerosis

Koubiyr

Dulau‐Metras

Deloire

et al. 2021

J of Neuroscience Research

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Theory of mind (ToM) seems to be affected in multiple sclerosis (MS). MRI studies suggested a role of the amygdala in social cognitive performances. Therefore, we explored the role of the amygdala network in ToM using a multimodal MRI approach. In MS, patients with impaired ToM showed contradictory dysexecutive neuropsychological profile. Therefore, we compared neural networks involved in ToM and executive functions (EFs). Twenty patients with relapsing‐remitting MS and 15 matched healthy controls were selected. ToM (Faux Pas test and mind stories) and EFs were assessed within and outside the scanner. All subjects underwent a battery of neuropsychological tests. Multimodal MRI with structural (diffusion imaging) and functional (resting‐state and task‐based) sequences was used to analyze the role and connections of the amygdala in ToM functioning. Cognitive and ToM performances were similar between patients and controls. Resting‐state data revealed decreased connectivity of the left amygdala with frontal areas in patients compared to controls (p < 0.0001). During the task‐based functional MRI, patients demonstrated increased connectivity between the amygdala and several cerebellar and left temporal regions (all p < 0.05). The microstructural alterations between the left amygdala and left temporal regions were associated with increased functional connectivity within the same pathway (r = 0.74; p < 0.01). No overlap was observed between functional networks involved in ToM and EFs. Our study demonstrates more connectivity recruitment between the amygdala and cerebellar and temporal regions in MS patients to reach preserved ToM performance. Microstructural abnormalities have been related to this compensatory network. Finally, different networks were involved in EFs and ToM.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amygdala network reorganization mediates the theory of mind performances in multiple sclerosis

Koubiyr

Dulau‐Metras

Deloire

et al. 2021

J of Neuroscience Research

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“…Functional imaging studies using social cognition paradigms or neuropsychological tools and resting-state protocols have shown abnormal activation or co-modulation patterns in the occipital regions (Han et al, 2016;Taylor et al, 2011); highlighted the connectivity of the fusiform area to social cognition impairment; and supported that visual processing areas are functionally related to social cognition (Labbe et al, 2020), even in experimental paradigms in close to real-life conditions (Wolf et al, 2010). Structural neuroimaging studies have also identified significant correlations between decreased WM integrity in the left occipital WM region and facial emotional perception performance in individuals with schizophrenia (Miyata et al, 2010).…”

Section: Social Cognitionmentioning

confidence: 99%

Executive Dysfunction, Social Cognition Impairment, and Gray Matter Pathology in Myotonic Dystrophy Type 2: A Pilot Study

Theodosiou

Christidi

Xirou

et al. 2022

Cognitive and Behavioral Neurology

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Background: In contrast to myotonic dystrophy type 1, the cognitive and radiologic profile of myotonic dystrophy type 2 (DM2) is relatively poorly characterized. Objective: To conduct a pilot study to systematically evaluate cognitive and radiologic features in a cohort of Greek individuals with DM2. Method: Eleven genetically confirmed individuals with DM2 and 26 age- and education-matched healthy controls were administered the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS) to screen for impairment in multiple cognitive domains. MRI data were evaluated by morphometric analyses to identify disease-specific gray and white matter alterations. The following statistical thresholds were used for cognitive comparisons: P FDR < 0.05 and Bayes factor (BF10) >10. Results: The DM2 group exhibited cognitive impairment (ECAS Total score; P FDR = 0.001; BF10 = 108.887), which was dominated by executive impairment (P FDR = 0.003; BF10 = 25.330). A trend toward verbal fluency impairment was also identified. No significant impairments in memory, language, or visuospatial function were captured. The analysis of subscores revealed severe impairments in social cognition and alternation. Voxel-based morphometry identified widespread frontal, occipital, and subcortical gray matter atrophy, including the left superior medial frontal gyrus, right medial orbitofrontal gyrus, right operculum, right precuneus, bilateral fusiform gyri, and bilateral thalami. Conclusion: DM2 may be associated with multifocal cortical and thalamic atrophy, which is likely to underpin the range of cognitive manifestations mostly characterized by executive impairment and specifically by impaired social cognition.

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“…By adopting an explorative perspective, Bisecco et al. (2019 ) reported a significant link between resting-state FC of the default mode network, the executive network, and the limbic network, and ToM performance in MS. Also, Labbe et al. (2020) revealed that ToM difficulties were linked to the connectivity of cerebellar areas and the amygdala.…”

Section: Introductionmentioning

confidence: 99%

Resting-state functional brain connectivity for human mentalizing: biobehavioral mechanisms of theory of mind in multiple sclerosis

Isernia

Pirastru

Massaro

et al. 2021

Social Cognitive and Affective Neuroscience

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Although neural hubs of mentalizing are acknowledged, the brain mechanisms underlying mentalizing deficit, characterizing different neurological conditions, are still a matter of debate. To investigate the neural underpinning of Theory of Mind (ToM) deficit in Multiple Sclerosis (MS), a region of interest (ROI)-based resting-state fMRI study was proposed. 37 MS patients (23 females, mean age=54.08±11.37 years, median Expanded Disability Status Scale=6.00) underwent an MRI and a neuro-psychosocial examination, and were compared with 20 sex-age-education matched healthy subjects. A neuroanatomical ToM model was constructed deriving 11 bilateral ROI, then between and within-functional connectivity (FC) were assessed to test for group differences. Correlation with psychosocial scores was also investigated. Lower ToM performance was registered for MS both in cognitive and affective ToM, significantly associated with processing speed. A disconnection between limbic-paralimbic network and prefrontal execution loops was observed. A trend of aberrant intrinsic connectivity in MS within the anterior cingulate cortex (ACC) was also reported. Finally, a correlation between cognitive ToM and intrinsic FC was detected in ACC and dorsal striatum, belonging to the limbic-paralimbic network, likely explaining the behavioral deficit in MS. The results suggest that aberrant intrinsic and extrinsic connectivity constitutes a crucial neural mechanism underlying ToM deficit in MS.

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Social cognition in Multiple Sclerosis is associated to changes in brain connectivity: A resting-state fMRI study

Cited by 13 publications

References 27 publications

Amygdala network reorganization mediates the theory of mind performances in multiple sclerosis

Amygdala network reorganization mediates the theory of mind performances in multiple sclerosis

Executive Dysfunction, Social Cognition Impairment, and Gray Matter Pathology in Myotonic Dystrophy Type 2: A Pilot Study

Resting-state functional brain connectivity for human mentalizing: biobehavioral mechanisms of theory of mind in multiple sclerosis

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