Social Class and Serum-Uric-Acid

Saha, N; Banerjee, Baisakhi

doi:10.1016/s0140-6736(70)91261-4

Cited by 1 publication

(1 citation statement)

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“…All interactions of the three covariates (gender, race/ethnicity, and MetS status) were initially included in the model, but removed in a stepwise fashion if the associated interaction p-value was <0.15. We also included education [38], poverty [38], and smoking [15] in the model due to known effects on levels of uric acid. While potentially important as confounders, drug and alcohol use were not included in the model because these were not available for NHANES participants <20 y.o.…”

Section: Methodsmentioning

confidence: 99%

Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006

2012

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Background Among adolescents uric acid is associated with insulin resistance, hypertension and the metabolic syndrome (MetS) and in adults high uric acid levels are an independent risk factor for cardiovascular disease and diabetes. Objective Determine whether the relationship of uric acid with MetS varies in adolescents by race/ethnicity and gender. Methods We used linear regression to evaluate associations between uric acid and other MetS-associated clinical and laboratory measures among 3,296 non-Hispanic-white, non-Hispanic-black and Hispanic adolescents age 12–19y participating in the National Health and Nutrition Evaluation Survey (1999–2006). Results Overall, non-Hispanic-white males and females had the highest uric acid levels among the three racial/ethnic groups. In each racial/ethnic group there were higher uric acid levels for those adolescents with vs. without MetS. However, the extent of the MetS-related increase in uric acid level varied by race and gender. Among males, MetS was associated with the greatest increases in uric acid among non-Hispanic whites. However, among females, the MetS-related increase in uric acid was greatest among non-whites. Non-Hispanic-white females exhibited the lowest degrees of correlation between levels of uric acid and MetS-associated variables. Uric acid levels did not correlate with insulin levels in non-Hispanic-white females. Conclusions These data suggest the relationship between uric acid and MetS varies by race/ethnicity and gender. In particular, non-Hispanic-white males exhibit a strong relationship and non-Hispanic-white females exhibit a relatively poor correlation between uric acid and MetS-related factors. These data may have implications for the use of uric acid as a marker of future risk among adolescents.

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Section: Methodsmentioning

confidence: 99%